{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "OFF LABEL USE",
      "count": 1181
    },
    {
      "term": "DRUG INEFFECTIVE",
      "count": 1013
    },
    {
      "term": "METHAEMOGLOBINAEMIA",
      "count": 482
    },
    {
      "term": "PYREXIA",
      "count": 459
    },
    {
      "term": "FATIGUE",
      "count": 455
    },
    {
      "term": "NAUSEA",
      "count": 454
    },
    {
      "term": "DIARRHOEA",
      "count": 407
    },
    {
      "term": "PNEUMONIA",
      "count": 387
    },
    {
      "term": "DYSPNOEA",
      "count": 375
    },
    {
      "term": "DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS",
      "count": 370
    },
    {
      "term": "ANAEMIA",
      "count": 361
    },
    {
      "term": "RASH",
      "count": 353
    },
    {
      "term": "PAIN",
      "count": 349
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 343
    },
    {
      "term": "TREATMENT FAILURE",
      "count": 338
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 322
    },
    {
      "term": "ASTHENIA",
      "count": 278
    },
    {
      "term": "HEADACHE",
      "count": 275
    },
    {
      "term": "VOMITING",
      "count": 270
    },
    {
      "term": "ACUTE KIDNEY INJURY",
      "count": 238
    },
    {
      "term": "SEPSIS",
      "count": 233
    },
    {
      "term": "DEATH",
      "count": 232
    },
    {
      "term": "RENAL FAILURE",
      "count": 227
    },
    {
      "term": "DRUG INEFFECTIVE FOR UNAPPROVED INDICATION",
      "count": 212
    },
    {
      "term": "DIZZINESS",
      "count": 205
    },
    {
      "term": "PRURITUS",
      "count": 204
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 201
    },
    {
      "term": "DRUG INTERACTION",
      "count": 190
    },
    {
      "term": "ANXIETY",
      "count": 188
    },
    {
      "term": "HYPERTENSION",
      "count": 187
    },
    {
      "term": "MALAISE",
      "count": 185
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 173
    },
    {
      "term": "HYPOTENSION",
      "count": 173
    },
    {
      "term": "HAEMOLYTIC ANAEMIA",
      "count": 171
    },
    {
      "term": "NEUTROPENIA",
      "count": 171
    },
    {
      "term": "PANCYTOPENIA",
      "count": 170
    },
    {
      "term": "WEIGHT DECREASED",
      "count": 170
    },
    {
      "term": "COUGH",
      "count": 167
    },
    {
      "term": "ARTHRALGIA",
      "count": 165
    },
    {
      "term": "DRUG HYPERSENSITIVITY",
      "count": 155
    },
    {
      "term": "WEIGHT INCREASED",
      "count": 149
    },
    {
      "term": "URTICARIA",
      "count": 148
    },
    {
      "term": "PRODUCT DOSE OMISSION ISSUE",
      "count": 144
    },
    {
      "term": "PLATELET COUNT DECREASED",
      "count": 141
    },
    {
      "term": "EMOTIONAL DISTRESS",
      "count": 138
    },
    {
      "term": "HAEMOGLOBIN DECREASED",
      "count": 137
    },
    {
      "term": "HYPOXIA",
      "count": 137
    },
    {
      "term": "DEPRESSION",
      "count": 136
    },
    {
      "term": "CHRONIC KIDNEY DISEASE",
      "count": 135
    },
    {
      "term": "ERYTHEMA",
      "count": 135
    },
    {
      "term": "DECREASED APPETITE",
      "count": 134
    },
    {
      "term": "CONSTIPATION",
      "count": 131
    },
    {
      "term": "RENAL IMPAIRMENT",
      "count": 130
    },
    {
      "term": "WHITE BLOOD CELL COUNT DECREASED",
      "count": 130
    },
    {
      "term": "FALL",
      "count": 128
    },
    {
      "term": "OEDEMA PERIPHERAL",
      "count": 126
    },
    {
      "term": "DISEASE PROGRESSION",
      "count": 125
    },
    {
      "term": "FEBRILE NEUTROPENIA",
      "count": 125
    },
    {
      "term": "NEUROPATHY PERIPHERAL",
      "count": 124
    },
    {
      "term": "BLOOD CREATININE INCREASED",
      "count": 123
    },
    {
      "term": "RESPIRATORY FAILURE",
      "count": 120
    },
    {
      "term": "THERAPY NON-RESPONDER",
      "count": 117
    },
    {
      "term": "INFECTION",
      "count": 115
    },
    {
      "term": "DEHYDRATION",
      "count": 113
    },
    {
      "term": "OXYGEN SATURATION DECREASED",
      "count": 110
    },
    {
      "term": "CHEST PAIN",
      "count": 108
    },
    {
      "term": "INTENTIONAL PRODUCT USE ISSUE",
      "count": 108
    },
    {
      "term": "CONFUSIONAL STATE",
      "count": 107
    },
    {
      "term": "DRUG INTOLERANCE",
      "count": 107
    },
    {
      "term": "ANHEDONIA",
      "count": 106
    },
    {
      "term": "NO ADVERSE EVENT",
      "count": 105
    },
    {
      "term": "BACK PAIN",
      "count": 103
    },
    {
      "term": "CHILLS",
      "count": 103
    },
    {
      "term": "DRUG-INDUCED LIVER INJURY",
      "count": 100
    },
    {
      "term": "INSOMNIA",
      "count": 99
    },
    {
      "term": "LEUKOPENIA",
      "count": 99
    },
    {
      "term": "PRODUCT USE ISSUE",
      "count": 96
    },
    {
      "term": "FEELING ABNORMAL",
      "count": 95
    },
    {
      "term": "BLOOD PRESSURE INCREASED",
      "count": 94
    },
    {
      "term": "MUSCLE SPASMS",
      "count": 93
    },
    {
      "term": "PAIN IN EXTREMITY",
      "count": 92
    },
    {
      "term": "PULMONARY EMBOLISM",
      "count": 92
    },
    {
      "term": "MYALGIA",
      "count": 90
    },
    {
      "term": "ANGIOEDEMA",
      "count": 89
    },
    {
      "term": "OSTEOPOROSIS",
      "count": 89
    },
    {
      "term": "URINARY TRACT INFECTION",
      "count": 87
    },
    {
      "term": "PERIPHERAL SWELLING",
      "count": 86
    },
    {
      "term": "GAIT DISTURBANCE",
      "count": 85
    },
    {
      "term": "COVID-19",
      "count": 83
    },
    {
      "term": "DEEP VEIN THROMBOSIS",
      "count": 83
    },
    {
      "term": "HYPERSENSITIVITY",
      "count": 83
    },
    {
      "term": "TOXICITY TO VARIOUS AGENTS",
      "count": 82
    },
    {
      "term": "BLISTER",
      "count": 81
    },
    {
      "term": "DISEASE RECURRENCE",
      "count": 79
    },
    {
      "term": "HAEMOLYSIS",
      "count": 78
    },
    {
      "term": "RENAL FAILURE ACUTE",
      "count": 78
    },
    {
      "term": "SKIN EXFOLIATION",
      "count": 78
    },
    {
      "term": "CATARACT",
      "count": 76
    },
    {
      "term": "CELLULITIS",
      "count": 74
    },
    {
      "term": "ADVERSE DRUG REACTION",
      "count": 73
    }
  ]
}