{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "DRUG INEFFECTIVE",
      "count": 452
    },
    {
      "term": "OFF LABEL USE",
      "count": 422
    },
    {
      "term": "HEADACHE",
      "count": 319
    },
    {
      "term": "HEREDITARY ANGIOEDEMA",
      "count": 230
    },
    {
      "term": "ANGIOEDEMA",
      "count": 229
    },
    {
      "term": "HYPERSENSITIVITY",
      "count": 227
    },
    {
      "term": "DRUG INTOLERANCE",
      "count": 215
    },
    {
      "term": "DRUG INEFFECTIVE FOR UNAPPROVED INDICATION",
      "count": 214
    },
    {
      "term": "DYSPHONIA",
      "count": 212
    },
    {
      "term": "SWELLING FACE",
      "count": 212
    },
    {
      "term": "SWOLLEN TONGUE",
      "count": 207
    },
    {
      "term": "PLATELET COUNT DECREASED",
      "count": 197
    },
    {
      "term": "FATIGUE",
      "count": 183
    },
    {
      "term": "NAUSEA",
      "count": 181
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 153
    },
    {
      "term": "HAEMOGLOBIN DECREASED",
      "count": 149
    },
    {
      "term": "DEATH",
      "count": 141
    },
    {
      "term": "CONSTIPATION",
      "count": 129
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 124
    },
    {
      "term": "ASTHENIA",
      "count": 120
    },
    {
      "term": "ANAEMIA",
      "count": 112
    },
    {
      "term": "HEPATIC ENZYME INCREASED",
      "count": 110
    },
    {
      "term": "NEUTROPENIA",
      "count": 103
    },
    {
      "term": "PAIN",
      "count": 103
    },
    {
      "term": "HAEMOLYSIS",
      "count": 101
    },
    {
      "term": "INFUSION RELATED REACTION",
      "count": 98
    },
    {
      "term": "MALAISE",
      "count": 98
    },
    {
      "term": "DIARRHOEA",
      "count": 95
    },
    {
      "term": "PNEUMONIA",
      "count": 95
    },
    {
      "term": "MIGRAINE",
      "count": 94
    },
    {
      "term": "DYSPNOEA",
      "count": 93
    },
    {
      "term": "COOMBS POSITIVE HAEMOLYTIC ANAEMIA",
      "count": 86
    },
    {
      "term": "LYMPHADENITIS",
      "count": 86
    },
    {
      "term": "DIZZINESS",
      "count": 84
    },
    {
      "term": "FALL",
      "count": 80
    },
    {
      "term": "THERAPEUTIC PRODUCT EFFECT DECREASED",
      "count": 76
    },
    {
      "term": "VOMITING",
      "count": 75
    },
    {
      "term": "WEIGHT DECREASED",
      "count": 75
    },
    {
      "term": "DRUG INTERACTION",
      "count": 72
    },
    {
      "term": "PYREXIA",
      "count": 72
    },
    {
      "term": "CONTUSION",
      "count": 68
    },
    {
      "term": "SEPSIS",
      "count": 66
    },
    {
      "term": "ARTHRALGIA",
      "count": 64
    },
    {
      "term": "WEIGHT INCREASED",
      "count": 64
    },
    {
      "term": "PAIN IN EXTREMITY",
      "count": 61
    },
    {
      "term": "RASH",
      "count": 59
    },
    {
      "term": "RHABDOMYOLYSIS",
      "count": 58
    },
    {
      "term": "BACK PAIN",
      "count": 56
    },
    {
      "term": "COUGH",
      "count": 53
    },
    {
      "term": "PRODUCT DOSE OMISSION ISSUE",
      "count": 53
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 52
    },
    {
      "term": "HYPERTENSION",
      "count": 51
    },
    {
      "term": "PRODUCT USE ISSUE",
      "count": 50
    },
    {
      "term": "RENAL FAILURE",
      "count": 49
    },
    {
      "term": "EPISTAXIS",
      "count": 48
    },
    {
      "term": "WHITE BLOOD CELL COUNT DECREASED",
      "count": 48
    },
    {
      "term": "COVID-19",
      "count": 47
    },
    {
      "term": "PRURITUS",
      "count": 47
    },
    {
      "term": "GAIT DISTURBANCE",
      "count": 46
    },
    {
      "term": "HAEMORRHAGE",
      "count": 46
    },
    {
      "term": "INFLUENZA",
      "count": 46
    },
    {
      "term": "THERAPEUTIC RESPONSE DECREASED",
      "count": 46
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 44
    },
    {
      "term": "INAPPROPRIATE SCHEDULE OF PRODUCT ADMINISTRATION",
      "count": 44
    },
    {
      "term": "INSOMNIA",
      "count": 42
    },
    {
      "term": "CHEST PAIN",
      "count": 41
    },
    {
      "term": "MYELODYSPLASTIC SYNDROME",
      "count": 41
    },
    {
      "term": "INTENTIONAL PRODUCT USE ISSUE",
      "count": 40
    },
    {
      "term": "ABDOMINAL PAIN UPPER",
      "count": 39
    },
    {
      "term": "DECREASED APPETITE",
      "count": 39
    },
    {
      "term": "FEELING ABNORMAL",
      "count": 39
    },
    {
      "term": "THERAPY NON-RESPONDER",
      "count": 39
    },
    {
      "term": "GENERAL PHYSICAL HEALTH DETERIORATION",
      "count": 38
    },
    {
      "term": "PERIPHERAL SWELLING",
      "count": 38
    },
    {
      "term": "MYELOFIBROSIS",
      "count": 37
    },
    {
      "term": "RENAL IMPAIRMENT",
      "count": 37
    },
    {
      "term": "SPLENOMEGALY",
      "count": 37
    },
    {
      "term": "GASTROINTESTINAL HAEMORRHAGE",
      "count": 36
    },
    {
      "term": "BLOOD PRESSURE INCREASED",
      "count": 35
    },
    {
      "term": "DEPRESSION",
      "count": 35
    },
    {
      "term": "URINARY TRACT INFECTION",
      "count": 35
    },
    {
      "term": "PLATELET COUNT INCREASED",
      "count": 34
    },
    {
      "term": "ANXIETY",
      "count": 33
    },
    {
      "term": "BLOOD CREATININE INCREASED",
      "count": 33
    },
    {
      "term": "INFECTION",
      "count": 33
    },
    {
      "term": "LOSS OF CONSCIOUSNESS",
      "count": 33
    },
    {
      "term": "ABDOMINAL DISCOMFORT",
      "count": 31
    },
    {
      "term": "ALANINE AMINOTRANSFERASE INCREASED",
      "count": 31
    },
    {
      "term": "ATRIAL FIBRILLATION",
      "count": 31
    },
    {
      "term": "MYALGIA",
      "count": 31
    },
    {
      "term": "STRESS",
      "count": 31
    },
    {
      "term": "WHITE BLOOD CELL COUNT INCREASED",
      "count": 31
    },
    {
      "term": "ACUTE MYOCARDIAL INFARCTION",
      "count": 30
    },
    {
      "term": "DISEASE PROGRESSION",
      "count": 30
    },
    {
      "term": "NO ADVERSE EVENT",
      "count": 30
    },
    {
      "term": "RENAL FAILURE ACUTE",
      "count": 30
    },
    {
      "term": "ABDOMINAL DISTENSION",
      "count": 29
    },
    {
      "term": "MUSCLE SPASMS",
      "count": 29
    },
    {
      "term": "NASOPHARYNGITIS",
      "count": 29
    },
    {
      "term": "OEDEMA PERIPHERAL",
      "count": 29
    }
  ]
}