{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "OFF LABEL USE",
      "count": 282
    },
    {
      "term": "FEBRILE NEUTROPENIA",
      "count": 195
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 134
    },
    {
      "term": "NEUTROPENIA",
      "count": 128
    },
    {
      "term": "DRUG INEFFECTIVE",
      "count": 116
    },
    {
      "term": "VOMITING",
      "count": 107
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 105
    },
    {
      "term": "ANAEMIA",
      "count": 88
    },
    {
      "term": "DISEASE PROGRESSION",
      "count": 88
    },
    {
      "term": "PYREXIA",
      "count": 88
    },
    {
      "term": "VENOOCCLUSIVE LIVER DISEASE",
      "count": 77
    },
    {
      "term": "STOMATITIS",
      "count": 74
    },
    {
      "term": "VENOOCCLUSIVE DISEASE",
      "count": 74
    },
    {
      "term": "NAUSEA",
      "count": 73
    },
    {
      "term": "MUCOSAL INFLAMMATION",
      "count": 72
    },
    {
      "term": "ACUTE MYELOID LEUKAEMIA",
      "count": 71
    },
    {
      "term": "DRUG RESISTANCE",
      "count": 62
    },
    {
      "term": "MALIGNANT NEOPLASM PROGRESSION",
      "count": 62
    },
    {
      "term": "OVARIAN FAILURE",
      "count": 56
    },
    {
      "term": "TOXICITY TO VARIOUS AGENTS",
      "count": 55
    },
    {
      "term": "ASCITES",
      "count": 51
    },
    {
      "term": "PRODUCT USE ISSUE",
      "count": 50
    },
    {
      "term": "DIARRHOEA",
      "count": 49
    },
    {
      "term": "MYELOSUPPRESSION",
      "count": 47
    },
    {
      "term": "BONE MARROW FAILURE",
      "count": 46
    },
    {
      "term": "SEPSIS",
      "count": 44
    },
    {
      "term": "DEHYDRATION",
      "count": 43
    },
    {
      "term": "SECOND PRIMARY MALIGNANCY",
      "count": 41
    },
    {
      "term": "LEUKOPENIA",
      "count": 40
    },
    {
      "term": "NEUROPATHY PERIPHERAL",
      "count": 40
    },
    {
      "term": "NEOPLASM PROGRESSION",
      "count": 39
    },
    {
      "term": "SEPTIC SHOCK",
      "count": 39
    },
    {
      "term": "OTOTOXICITY",
      "count": 38
    },
    {
      "term": "NEUTROPHIL COUNT DECREASED",
      "count": 37
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 35
    },
    {
      "term": "NEUROTOXICITY",
      "count": 35
    },
    {
      "term": "PANCYTOPENIA",
      "count": 35
    },
    {
      "term": "WHITE BLOOD CELL COUNT DECREASED",
      "count": 35
    },
    {
      "term": "RESPIRATORY FAILURE",
      "count": 34
    },
    {
      "term": "MATERNAL EXPOSURE DURING PREGNANCY",
      "count": 33
    },
    {
      "term": "INFECTION",
      "count": 31
    },
    {
      "term": "PAIN",
      "count": 29
    },
    {
      "term": "HEADACHE",
      "count": 26
    },
    {
      "term": "DEATH",
      "count": 25
    },
    {
      "term": "DISSEMINATED INTRAVASCULAR COAGULATION",
      "count": 25
    },
    {
      "term": "DRUG TOXICITY",
      "count": 25
    },
    {
      "term": "FATIGUE",
      "count": 25
    },
    {
      "term": "MYELODYSPLASTIC SYNDROME",
      "count": 25
    },
    {
      "term": "HAEMATOTOXICITY",
      "count": 24
    },
    {
      "term": "METASTASES TO LUNG",
      "count": 24
    },
    {
      "term": "NEUTROPENIC SEPSIS",
      "count": 24
    },
    {
      "term": "WEIGHT DECREASED",
      "count": 24
    },
    {
      "term": "DECREASED APPETITE",
      "count": 23
    },
    {
      "term": "PLEURAL EFFUSION",
      "count": 23
    },
    {
      "term": "TUBULOINTERSTITIAL NEPHRITIS",
      "count": 23
    },
    {
      "term": "ACUTE RESPIRATORY DISTRESS SYNDROME",
      "count": 22
    },
    {
      "term": "CONSTIPATION",
      "count": 22
    },
    {
      "term": "HYPOPHAGIA",
      "count": 22
    },
    {
      "term": "PREMATURE BABY",
      "count": 22
    },
    {
      "term": "DRUG INEFFECTIVE FOR UNAPPROVED INDICATION",
      "count": 21
    },
    {
      "term": "DYSPNOEA",
      "count": 21
    },
    {
      "term": "PLATELET COUNT DECREASED",
      "count": 21
    },
    {
      "term": "RESPIRATORY DISTRESS",
      "count": 21
    },
    {
      "term": "TACHYCARDIA",
      "count": 21
    },
    {
      "term": "ALOPECIA",
      "count": 20
    },
    {
      "term": "ASTHENIA",
      "count": 20
    },
    {
      "term": "HEPATOMEGALY",
      "count": 20
    },
    {
      "term": "RENAL IMPAIRMENT",
      "count": 20
    },
    {
      "term": "ENCEPHALOPATHY",
      "count": 19
    },
    {
      "term": "HEPATIC FUNCTION ABNORMAL",
      "count": 19
    },
    {
      "term": "METASTASES TO LYMPH NODES",
      "count": 19
    },
    {
      "term": "PERIPHERAL SENSORY NEUROPATHY",
      "count": 19
    },
    {
      "term": "RENAL FAILURE",
      "count": 19
    },
    {
      "term": "DEAFNESS",
      "count": 18
    },
    {
      "term": "HAEMOGLOBIN DECREASED",
      "count": 18
    },
    {
      "term": "METASTASES TO LIVER",
      "count": 18
    },
    {
      "term": "PNEUMONIA",
      "count": 18
    },
    {
      "term": "RASH",
      "count": 18
    },
    {
      "term": "ALANINE AMINOTRANSFERASE INCREASED",
      "count": 17
    },
    {
      "term": "CARDIOTOXICITY",
      "count": 17
    },
    {
      "term": "EPISTAXIS",
      "count": 17
    },
    {
      "term": "HYPOTENSION",
      "count": 17
    },
    {
      "term": "NEPHROBLASTOMA",
      "count": 17
    },
    {
      "term": "HYPERBILIRUBINAEMIA",
      "count": 16
    },
    {
      "term": "ILEUS",
      "count": 16
    },
    {
      "term": "LYMPHOCYTE COUNT DECREASED",
      "count": 16
    },
    {
      "term": "METASTASIS",
      "count": 16
    },
    {
      "term": "THYROID CANCER",
      "count": 16
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 15
    },
    {
      "term": "DISEASE RECURRENCE",
      "count": 15
    },
    {
      "term": "GASTROINTESTINAL TOXICITY",
      "count": 15
    },
    {
      "term": "HEPATIC FAILURE",
      "count": 15
    },
    {
      "term": "METASTASES TO CENTRAL NERVOUS SYSTEM",
      "count": 15
    },
    {
      "term": "MULTIPLE ORGAN DYSFUNCTION SYNDROME",
      "count": 15
    },
    {
      "term": "TUMOUR LYSIS SYNDROME",
      "count": 15
    },
    {
      "term": "ACUTE KIDNEY INJURY",
      "count": 14
    },
    {
      "term": "CARDIAC FAILURE",
      "count": 14
    },
    {
      "term": "CONVULSION",
      "count": 14
    },
    {
      "term": "DELAYED PUBERTY",
      "count": 14
    },
    {
      "term": "DRUG INTOLERANCE",
      "count": 14
    }
  ]
}