{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "DRUG INEFFECTIVE",
      "count": 7464
    },
    {
      "term": "OFF LABEL USE",
      "count": 7339
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 3553
    },
    {
      "term": "PYREXIA",
      "count": 2724
    },
    {
      "term": "DIARRHOEA",
      "count": 2186
    },
    {
      "term": "NAUSEA",
      "count": 2050
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 2037
    },
    {
      "term": "PNEUMONIA",
      "count": 1959
    },
    {
      "term": "CYTOMEGALOVIRUS INFECTION",
      "count": 1931
    },
    {
      "term": "HYPERTENSION",
      "count": 1657
    },
    {
      "term": "SEPSIS",
      "count": 1655
    },
    {
      "term": "FATIGUE",
      "count": 1641
    },
    {
      "term": "RASH",
      "count": 1605
    },
    {
      "term": "GRAFT VERSUS HOST DISEASE",
      "count": 1593
    },
    {
      "term": "HEADACHE",
      "count": 1577
    },
    {
      "term": "TREATMENT FAILURE",
      "count": 1518
    },
    {
      "term": "PAIN",
      "count": 1512
    },
    {
      "term": "INFECTION",
      "count": 1472
    },
    {
      "term": "PRURITUS",
      "count": 1447
    },
    {
      "term": "RENAL IMPAIRMENT",
      "count": 1387
    },
    {
      "term": "DRUG INTOLERANCE",
      "count": 1365
    },
    {
      "term": "VOMITING",
      "count": 1340
    },
    {
      "term": "ARTHRALGIA",
      "count": 1332
    },
    {
      "term": "DRUG INTERACTION",
      "count": 1322
    },
    {
      "term": "DRUG INEFFECTIVE FOR UNAPPROVED INDICATION",
      "count": 1314
    },
    {
      "term": "ACUTE KIDNEY INJURY",
      "count": 1286
    },
    {
      "term": "DYSPNOEA",
      "count": 1286
    },
    {
      "term": "PSORIASIS",
      "count": 1279
    },
    {
      "term": "ACUTE GRAFT VERSUS HOST DISEASE",
      "count": 1238
    },
    {
      "term": "CHRONIC GRAFT VERSUS HOST DISEASE",
      "count": 1214
    },
    {
      "term": "RENAL FAILURE",
      "count": 1208
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 1205
    },
    {
      "term": "BLOOD CREATININE INCREASED",
      "count": 1181
    },
    {
      "term": "ANAEMIA",
      "count": 1135
    },
    {
      "term": "DEATH",
      "count": 1118
    },
    {
      "term": "NEUTROPENIA",
      "count": 1051
    },
    {
      "term": "CYTOMEGALOVIRUS INFECTION REACTIVATION",
      "count": 1034
    },
    {
      "term": "PANCYTOPENIA",
      "count": 1005
    },
    {
      "term": "ERYTHEMA",
      "count": 993
    },
    {
      "term": "ACUTE GRAFT VERSUS HOST DISEASE IN SKIN",
      "count": 983
    },
    {
      "term": "DRUG HYPERSENSITIVITY",
      "count": 960
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 949
    },
    {
      "term": "MALAISE",
      "count": 946
    },
    {
      "term": "FEBRILE NEUTROPENIA",
      "count": 945
    },
    {
      "term": "RESPIRATORY FAILURE",
      "count": 941
    },
    {
      "term": "EPSTEIN-BARR VIRUS INFECTION",
      "count": 935
    },
    {
      "term": "THERAPY NON-RESPONDER",
      "count": 935
    },
    {
      "term": "MUCOSAL INFLAMMATION",
      "count": 906
    },
    {
      "term": "DISEASE PROGRESSION",
      "count": 904
    },
    {
      "term": "ASTHENIA",
      "count": 903
    },
    {
      "term": "SEPTIC SHOCK",
      "count": 872
    },
    {
      "term": "THROMBOTIC MICROANGIOPATHY",
      "count": 870
    },
    {
      "term": "URTICARIA",
      "count": 864
    },
    {
      "term": "RHEUMATOID ARTHRITIS",
      "count": 837
    },
    {
      "term": "ALANINE AMINOTRANSFERASE INCREASED",
      "count": 833
    },
    {
      "term": "COVID-19",
      "count": 832
    },
    {
      "term": "NEPHROPATHY TOXIC",
      "count": 832
    },
    {
      "term": "PRODUCT USE ISSUE",
      "count": 816
    },
    {
      "term": "WEIGHT DECREASED",
      "count": 814
    },
    {
      "term": "THERAPEUTIC PRODUCT EFFECT INCOMPLETE",
      "count": 806
    },
    {
      "term": "BK VIRUS INFECTION",
      "count": 800
    },
    {
      "term": "MULTIPLE ORGAN DYSFUNCTION SYNDROME",
      "count": 797
    },
    {
      "term": "PLATELET COUNT DECREASED",
      "count": 796
    },
    {
      "term": "COUGH",
      "count": 792
    },
    {
      "term": "POST TRANSPLANT LYMPHOPROLIFERATIVE DISORDER",
      "count": 789
    },
    {
      "term": "C-REACTIVE PROTEIN INCREASED",
      "count": 732
    },
    {
      "term": "HYPERSENSITIVITY",
      "count": 728
    },
    {
      "term": "PAIN IN EXTREMITY",
      "count": 726
    },
    {
      "term": "ASPARTATE AMINOTRANSFERASE INCREASED",
      "count": 711
    },
    {
      "term": "PSORIATIC ARTHROPATHY",
      "count": 711
    },
    {
      "term": "TRANSPLANT REJECTION",
      "count": 698
    },
    {
      "term": "JOINT SWELLING",
      "count": 681
    },
    {
      "term": "DISEASE RECURRENCE",
      "count": 676
    },
    {
      "term": "TOXICITY TO VARIOUS AGENTS",
      "count": 674
    },
    {
      "term": "URINARY TRACT INFECTION",
      "count": 666
    },
    {
      "term": "HAEMOGLOBIN DECREASED",
      "count": 660
    },
    {
      "term": "LEUKOPENIA",
      "count": 645
    },
    {
      "term": "POSTERIOR REVERSIBLE ENCEPHALOPATHY SYNDROME",
      "count": 638
    },
    {
      "term": "CONTRAINDICATED PRODUCT ADMINISTERED",
      "count": 633
    },
    {
      "term": "PERIPHERAL SWELLING",
      "count": 628
    },
    {
      "term": "THERAPEUTIC RESPONSE DECREASED",
      "count": 628
    },
    {
      "term": "DIZZINESS",
      "count": 627
    },
    {
      "term": "INFLAMMATION",
      "count": 622
    },
    {
      "term": "THERAPEUTIC PRODUCT EFFECT DECREASED",
      "count": 621
    },
    {
      "term": "CYTOMEGALOVIRUS VIRAEMIA",
      "count": 608
    },
    {
      "term": "GRAFT VERSUS HOST DISEASE IN GASTROINTESTINAL TRACT",
      "count": 593
    },
    {
      "term": "BLOOD PRESSURE INCREASED",
      "count": 591
    },
    {
      "term": "INSOMNIA",
      "count": 586
    },
    {
      "term": "HEPATIC ENZYME INCREASED",
      "count": 567
    },
    {
      "term": "CYSTITIS HAEMORRHAGIC",
      "count": 566
    },
    {
      "term": "INFUSION RELATED REACTION",
      "count": 561
    },
    {
      "term": "DRUG RESISTANCE",
      "count": 545
    },
    {
      "term": "BACTERIAL INFECTION",
      "count": 534
    },
    {
      "term": "GRAFT VERSUS HOST DISEASE IN SKIN",
      "count": 534
    },
    {
      "term": "WEIGHT INCREASED",
      "count": 529
    },
    {
      "term": "GENERAL PHYSICAL HEALTH DETERIORATION",
      "count": 527
    },
    {
      "term": "ALOPECIA",
      "count": 524
    },
    {
      "term": "STAPHYLOCOCCAL INFECTION",
      "count": 520
    },
    {
      "term": "ABDOMINAL DISCOMFORT",
      "count": 514
    },
    {
      "term": "FUNGAL INFECTION",
      "count": 514
    }
  ]
}