{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "OFF LABEL USE",
      "count": 16720
    },
    {
      "term": "FEBRILE NEUTROPENIA",
      "count": 15004
    },
    {
      "term": "NEUTROPENIA",
      "count": 10822
    },
    {
      "term": "DRUG INEFFECTIVE",
      "count": 10688
    },
    {
      "term": "PYREXIA",
      "count": 9441
    },
    {
      "term": "DISEASE PROGRESSION",
      "count": 8502
    },
    {
      "term": "PNEUMONIA",
      "count": 6788
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 6637
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 6634
    },
    {
      "term": "NAUSEA",
      "count": 6411
    },
    {
      "term": "ANAEMIA",
      "count": 6222
    },
    {
      "term": "SEPSIS",
      "count": 5878
    },
    {
      "term": "DEATH",
      "count": 5870
    },
    {
      "term": "DIARRHOEA",
      "count": 5643
    },
    {
      "term": "VOMITING",
      "count": 4990
    },
    {
      "term": "INFECTION",
      "count": 4732
    },
    {
      "term": "PANCYTOPENIA",
      "count": 4419
    },
    {
      "term": "FATIGUE",
      "count": 4382
    },
    {
      "term": "WHITE BLOOD CELL COUNT DECREASED",
      "count": 4325
    },
    {
      "term": "MYELOSUPPRESSION",
      "count": 4203
    },
    {
      "term": "DYSPNOEA",
      "count": 3918
    },
    {
      "term": "CYTOKINE RELEASE SYNDROME",
      "count": 3742
    },
    {
      "term": "MUCOSAL INFLAMMATION",
      "count": 3648
    },
    {
      "term": "NEUROPATHY PERIPHERAL",
      "count": 3524
    },
    {
      "term": "MALIGNANT NEOPLASM PROGRESSION",
      "count": 3286
    },
    {
      "term": "PLATELET COUNT DECREASED",
      "count": 3267
    },
    {
      "term": "ASTHENIA",
      "count": 3240
    },
    {
      "term": "RESPIRATORY FAILURE",
      "count": 3143
    },
    {
      "term": "LEUKOPENIA",
      "count": 3120
    },
    {
      "term": "SEPTIC SHOCK",
      "count": 3117
    },
    {
      "term": "NEUTROPHIL COUNT DECREASED",
      "count": 3076
    },
    {
      "term": "HYPOTENSION",
      "count": 2875
    },
    {
      "term": "ACUTE KIDNEY INJURY",
      "count": 2800
    },
    {
      "term": "PLASMA CELL MYELOMA",
      "count": 2642
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 2620
    },
    {
      "term": "HEADACHE",
      "count": 2482
    },
    {
      "term": "COVID-19",
      "count": 2421
    },
    {
      "term": "MYELODYSPLASTIC SYNDROME",
      "count": 2394
    },
    {
      "term": "ACUTE MYELOID LEUKAEMIA",
      "count": 2385
    },
    {
      "term": "CYTOMEGALOVIRUS INFECTION",
      "count": 2376
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 2244
    },
    {
      "term": "BONE MARROW FAILURE",
      "count": 2217
    },
    {
      "term": "ALOPECIA",
      "count": 2202
    },
    {
      "term": "TOXICITY TO VARIOUS AGENTS",
      "count": 2195
    },
    {
      "term": "DECREASED APPETITE",
      "count": 2149
    },
    {
      "term": "PAIN",
      "count": 2140
    },
    {
      "term": "COUGH",
      "count": 2128
    },
    {
      "term": "CARDIAC FAILURE",
      "count": 2080
    },
    {
      "term": "RENAL FAILURE",
      "count": 2079
    },
    {
      "term": "RASH",
      "count": 2073
    },
    {
      "term": "INTERSTITIAL LUNG DISEASE",
      "count": 2025
    },
    {
      "term": "PLEURAL EFFUSION",
      "count": 2020
    },
    {
      "term": "HAEMOGLOBIN DECREASED",
      "count": 1987
    },
    {
      "term": "MULTIPLE ORGAN DYSFUNCTION SYNDROME",
      "count": 1927
    },
    {
      "term": "HYPERTENSION",
      "count": 1817
    },
    {
      "term": "PULMONARY EMBOLISM",
      "count": 1784
    },
    {
      "term": "DISEASE RECURRENCE",
      "count": 1763
    },
    {
      "term": "CONSTIPATION",
      "count": 1762
    },
    {
      "term": "NEOPLASM PROGRESSION",
      "count": 1746
    },
    {
      "term": "STOMATITIS",
      "count": 1728
    },
    {
      "term": "HAEMATOTOXICITY",
      "count": 1689
    },
    {
      "term": "DIFFUSE LARGE B-CELL LYMPHOMA",
      "count": 1683
    },
    {
      "term": "GENERAL PHYSICAL HEALTH DETERIORATION",
      "count": 1665
    },
    {
      "term": "THERAPY PARTIAL RESPONDER",
      "count": 1664
    },
    {
      "term": "INTENTIONAL PRODUCT USE ISSUE",
      "count": 1627
    },
    {
      "term": "MALAISE",
      "count": 1625
    },
    {
      "term": "DRUG INEFFECTIVE FOR UNAPPROVED INDICATION",
      "count": 1593
    },
    {
      "term": "CYTOPENIA",
      "count": 1582
    },
    {
      "term": "PRODUCT USE ISSUE",
      "count": 1559
    },
    {
      "term": "ACUTE GRAFT VERSUS HOST DISEASE",
      "count": 1495
    },
    {
      "term": "ATRIAL FIBRILLATION",
      "count": 1489
    },
    {
      "term": "THERAPY NON-RESPONDER",
      "count": 1489
    },
    {
      "term": "URINARY TRACT INFECTION",
      "count": 1489
    },
    {
      "term": "DIZZINESS",
      "count": 1481
    },
    {
      "term": "NEUROTOXICITY",
      "count": 1455
    },
    {
      "term": "WEIGHT DECREASED",
      "count": 1453
    },
    {
      "term": "ARTHRALGIA",
      "count": 1450
    },
    {
      "term": "TREATMENT FAILURE",
      "count": 1434
    },
    {
      "term": "HYPOGAMMAGLOBULINAEMIA",
      "count": 1419
    },
    {
      "term": "ALANINE AMINOTRANSFERASE INCREASED",
      "count": 1404
    },
    {
      "term": "GRAFT VERSUS HOST DISEASE",
      "count": 1393
    },
    {
      "term": "CHILLS",
      "count": 1391
    },
    {
      "term": "CYSTITIS HAEMORRHAGIC",
      "count": 1375
    },
    {
      "term": "DEHYDRATION",
      "count": 1359
    },
    {
      "term": "SECOND PRIMARY MALIGNANCY",
      "count": 1356
    },
    {
      "term": "RENAL IMPAIRMENT",
      "count": 1353
    },
    {
      "term": "LYMPHOPENIA",
      "count": 1334
    },
    {
      "term": "VENOOCCLUSIVE LIVER DISEASE",
      "count": 1323
    },
    {
      "term": "CYTOMEGALOVIRUS INFECTION REACTIVATION",
      "count": 1317
    },
    {
      "term": "BACK PAIN",
      "count": 1296
    },
    {
      "term": "TUMOUR LYSIS SYNDROME",
      "count": 1292
    },
    {
      "term": "DIFFUSE LARGE B-CELL LYMPHOMA RECURRENT",
      "count": 1291
    },
    {
      "term": "DEEP VEIN THROMBOSIS",
      "count": 1284
    },
    {
      "term": "HYPOKALAEMIA",
      "count": 1278
    },
    {
      "term": "PNEUMOCYSTIS JIROVECII PNEUMONIA",
      "count": 1273
    },
    {
      "term": "LYMPHADENOPATHY",
      "count": 1266
    },
    {
      "term": "NEUTROPENIC SEPSIS",
      "count": 1262
    },
    {
      "term": "AGRANULOCYTOSIS",
      "count": 1257
    },
    {
      "term": "PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY",
      "count": 1252
    },
    {
      "term": "CARDIOTOXICITY",
      "count": 1240
    }
  ]
}