{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "DEATH",
      "count": 695
    },
    {
      "term": "NEOPLASM PROGRESSION",
      "count": 461
    },
    {
      "term": "DISEASE PROGRESSION",
      "count": 284
    },
    {
      "term": "NAUSEA",
      "count": 268
    },
    {
      "term": "VOMITING",
      "count": 246
    },
    {
      "term": "MALIGNANT NEOPLASM PROGRESSION",
      "count": 230
    },
    {
      "term": "DIARRHOEA",
      "count": 212
    },
    {
      "term": "OFF LABEL USE",
      "count": 199
    },
    {
      "term": "DRUG INEFFECTIVE",
      "count": 161
    },
    {
      "term": "DYSPNOEA",
      "count": 154
    },
    {
      "term": "FATIGUE",
      "count": 148
    },
    {
      "term": "OEDEMA PERIPHERAL",
      "count": 143
    },
    {
      "term": "PLEURAL EFFUSION",
      "count": 135
    },
    {
      "term": "ASTHENIA",
      "count": 124
    },
    {
      "term": "PYREXIA",
      "count": 116
    },
    {
      "term": "DRUG RESISTANCE",
      "count": 115
    },
    {
      "term": "PNEUMONIA",
      "count": 112
    },
    {
      "term": "CONSTIPATION",
      "count": 111
    },
    {
      "term": "DECREASED APPETITE",
      "count": 105
    },
    {
      "term": "NON-SMALL CELL LUNG CANCER",
      "count": 104
    },
    {
      "term": "COUGH",
      "count": 100
    },
    {
      "term": "HEADACHE",
      "count": 100
    },
    {
      "term": "ALANINE AMINOTRANSFERASE INCREASED",
      "count": 99
    },
    {
      "term": "ANAEMIA",
      "count": 99
    },
    {
      "term": "METASTASES TO CENTRAL NERVOUS SYSTEM",
      "count": 93
    },
    {
      "term": "NEUTROPENIA",
      "count": 93
    },
    {
      "term": "DEHYDRATION",
      "count": 79
    },
    {
      "term": "ASPARTATE AMINOTRANSFERASE INCREASED",
      "count": 78
    },
    {
      "term": "DRUG INTERACTION",
      "count": 78
    },
    {
      "term": "RASH",
      "count": 73
    },
    {
      "term": "INTERSTITIAL LUNG DISEASE",
      "count": 71
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 70
    },
    {
      "term": "VISUAL IMPAIRMENT",
      "count": 70
    },
    {
      "term": "MALAISE",
      "count": 69
    },
    {
      "term": "PULMONARY EMBOLISM",
      "count": 69
    },
    {
      "term": "BLOOD CREATININE INCREASED",
      "count": 68
    },
    {
      "term": "DIZZINESS",
      "count": 68
    },
    {
      "term": "FEBRILE NEUTROPENIA",
      "count": 68
    },
    {
      "term": "GENERAL PHYSICAL HEALTH DETERIORATION",
      "count": 65
    },
    {
      "term": "OEDEMA",
      "count": 65
    },
    {
      "term": "HAEMOGLOBIN DECREASED",
      "count": 64
    },
    {
      "term": "PAIN",
      "count": 63
    },
    {
      "term": "STOMATITIS",
      "count": 63
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 61
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 61
    },
    {
      "term": "PNEUMONITIS",
      "count": 59
    },
    {
      "term": "TRANSAMINASES INCREASED",
      "count": 58
    },
    {
      "term": "ACUTE KIDNEY INJURY",
      "count": 57
    },
    {
      "term": "HYPOTENSION",
      "count": 56
    },
    {
      "term": "PERIPHERAL SWELLING",
      "count": 56
    },
    {
      "term": "ELECTROCARDIOGRAM QT PROLONGED",
      "count": 54
    },
    {
      "term": "RENAL FAILURE",
      "count": 53
    },
    {
      "term": "WHITE BLOOD CELL COUNT DECREASED",
      "count": 53
    },
    {
      "term": "NEOPLASM MALIGNANT",
      "count": 50
    },
    {
      "term": "WEIGHT DECREASED",
      "count": 50
    },
    {
      "term": "DEEP VEIN THROMBOSIS",
      "count": 49
    },
    {
      "term": "HEPATOTOXICITY",
      "count": 49
    },
    {
      "term": "LUNG ADENOCARCINOMA",
      "count": 49
    },
    {
      "term": "RESPIRATORY FAILURE",
      "count": 48
    },
    {
      "term": "SEPSIS",
      "count": 46
    },
    {
      "term": "HEPATIC FUNCTION ABNORMAL",
      "count": 45
    },
    {
      "term": "PERICARDIAL EFFUSION",
      "count": 45
    },
    {
      "term": "BACK PAIN",
      "count": 44
    },
    {
      "term": "VISION BLURRED",
      "count": 43
    },
    {
      "term": "WEIGHT INCREASED",
      "count": 43
    },
    {
      "term": "HYPONATRAEMIA",
      "count": 42
    },
    {
      "term": "HYPOKALAEMIA",
      "count": 41
    },
    {
      "term": "MYELOSUPPRESSION",
      "count": 41
    },
    {
      "term": "RENAL IMPAIRMENT",
      "count": 41
    },
    {
      "term": "SINUS BRADYCARDIA",
      "count": 41
    },
    {
      "term": "ACQUIRED GENE MUTATION",
      "count": 40
    },
    {
      "term": "BLOOD CREATINE PHOSPHOKINASE INCREASED",
      "count": 40
    },
    {
      "term": "BRADYCARDIA",
      "count": 40
    },
    {
      "term": "EMBOLISM",
      "count": 40
    },
    {
      "term": "NEUTROPHIL COUNT DECREASED",
      "count": 40
    },
    {
      "term": "LUNG NEOPLASM MALIGNANT",
      "count": 38
    },
    {
      "term": "OESOPHAGITIS",
      "count": 38
    },
    {
      "term": "PAIN IN EXTREMITY",
      "count": 38
    },
    {
      "term": "SEIZURE",
      "count": 38
    },
    {
      "term": "ATRIAL FIBRILLATION",
      "count": 37
    },
    {
      "term": "CHEST PAIN",
      "count": 37
    },
    {
      "term": "PRODUCT USE ISSUE",
      "count": 36
    },
    {
      "term": "BLOOD ALKALINE PHOSPHATASE INCREASED",
      "count": 35
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 34
    },
    {
      "term": "DYSPHAGIA",
      "count": 34
    },
    {
      "term": "METASTASES TO LIVER",
      "count": 34
    },
    {
      "term": "HYPOXIA",
      "count": 33
    },
    {
      "term": "ASCITES",
      "count": 32
    },
    {
      "term": "COVID-19",
      "count": 32
    },
    {
      "term": "HEPATIC FAILURE",
      "count": 32
    },
    {
      "term": "HYPOALBUMINAEMIA",
      "count": 32
    },
    {
      "term": "CELLULITIS",
      "count": 31
    },
    {
      "term": "HAEMOPTYSIS",
      "count": 31
    },
    {
      "term": "HYPERTENSION",
      "count": 31
    },
    {
      "term": "ABDOMINAL DISTENSION",
      "count": 30
    },
    {
      "term": "FALL",
      "count": 30
    },
    {
      "term": "LIVER DISORDER",
      "count": 30
    },
    {
      "term": "NEUROPATHY PERIPHERAL",
      "count": 30
    },
    {
      "term": "PLATELET COUNT DECREASED",
      "count": 30
    },
    {
      "term": "ARTHRALGIA",
      "count": 29
    }
  ]
}