{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "OFF LABEL USE",
      "count": 304
    },
    {
      "term": "DRUG INEFFECTIVE",
      "count": 213
    },
    {
      "term": "FEBRILE NEUTROPENIA",
      "count": 207
    },
    {
      "term": "PYREXIA",
      "count": 189
    },
    {
      "term": "PANCYTOPENIA",
      "count": 156
    },
    {
      "term": "NEUTROPENIA",
      "count": 154
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 126
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 122
    },
    {
      "term": "PNEUMONIA",
      "count": 106
    },
    {
      "term": "RASH MACULO-PAPULAR",
      "count": 93
    },
    {
      "term": "LYMPHOPENIA",
      "count": 86
    },
    {
      "term": "SEPSIS",
      "count": 85
    },
    {
      "term": "DISEASE PROGRESSION",
      "count": 84
    },
    {
      "term": "DEATH",
      "count": 80
    },
    {
      "term": "INFECTION",
      "count": 78
    },
    {
      "term": "ANAEMIA",
      "count": 75
    },
    {
      "term": "LEUKOPENIA",
      "count": 75
    },
    {
      "term": "NAUSEA",
      "count": 75
    },
    {
      "term": "MYELODYSPLASTIC SYNDROME",
      "count": 74
    },
    {
      "term": "FATIGUE",
      "count": 71
    },
    {
      "term": "MULTIPLE SCLEROSIS RELAPSE",
      "count": 69
    },
    {
      "term": "RASH",
      "count": 65
    },
    {
      "term": "SEPTIC SHOCK",
      "count": 64
    },
    {
      "term": "DIARRHOEA",
      "count": 57
    },
    {
      "term": "RESPIRATORY FAILURE",
      "count": 54
    },
    {
      "term": "ACUTE MYELOID LEUKAEMIA",
      "count": 53
    },
    {
      "term": "HEADACHE",
      "count": 53
    },
    {
      "term": "MYELOSUPPRESSION",
      "count": 53
    },
    {
      "term": "VOMITING",
      "count": 50
    },
    {
      "term": "HYPERSENSITIVITY",
      "count": 49
    },
    {
      "term": "ASTHENIA",
      "count": 47
    },
    {
      "term": "DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS",
      "count": 47
    },
    {
      "term": "HYPOTENSION",
      "count": 47
    },
    {
      "term": "MULTIPLE ORGAN DYSFUNCTION SYNDROME",
      "count": 46
    },
    {
      "term": "BONE MARROW FAILURE",
      "count": 44
    },
    {
      "term": "COVID-19",
      "count": 44
    },
    {
      "term": "DYSPNOEA",
      "count": 42
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 41
    },
    {
      "term": "HERPES ZOSTER",
      "count": 40
    },
    {
      "term": "MALIGNANT NEOPLASM PROGRESSION",
      "count": 40
    },
    {
      "term": "AGRANULOCYTOSIS",
      "count": 39
    },
    {
      "term": "HAEMATOTOXICITY",
      "count": 39
    },
    {
      "term": "PRURITUS",
      "count": 38
    },
    {
      "term": "THERAPY NON-RESPONDER",
      "count": 36
    },
    {
      "term": "TOXIC SKIN ERUPTION",
      "count": 36
    },
    {
      "term": "DRUG INEFFECTIVE FOR UNAPPROVED INDICATION",
      "count": 35
    },
    {
      "term": "PRODUCT USE ISSUE",
      "count": 35
    },
    {
      "term": "RENAL FAILURE",
      "count": 34
    },
    {
      "term": "BACTERAEMIA",
      "count": 33
    },
    {
      "term": "COUGH",
      "count": 32
    },
    {
      "term": "HYPERBILIRUBINAEMIA",
      "count": 32
    },
    {
      "term": "WHITE BLOOD CELL COUNT DECREASED",
      "count": 32
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 31
    },
    {
      "term": "LYMPHADENOPATHY",
      "count": 31
    },
    {
      "term": "ACUTE MYELOID LEUKAEMIA RECURRENT",
      "count": 30
    },
    {
      "term": "DISSEMINATED INTRAVASCULAR COAGULATION",
      "count": 30
    },
    {
      "term": "RENAL IMPAIRMENT",
      "count": 29
    },
    {
      "term": "GASTROINTESTINAL HAEMORRHAGE",
      "count": 28
    },
    {
      "term": "LYMPHOCYTE COUNT DECREASED",
      "count": 28
    },
    {
      "term": "TREATMENT FAILURE",
      "count": 28
    },
    {
      "term": "CONSTIPATION",
      "count": 27
    },
    {
      "term": "FACE OEDEMA",
      "count": 27
    },
    {
      "term": "HEPATIC FAILURE",
      "count": 27
    },
    {
      "term": "HEPATOTOXICITY",
      "count": 27
    },
    {
      "term": "MYALGIA",
      "count": 26
    },
    {
      "term": "OEDEMA PERIPHERAL",
      "count": 25
    },
    {
      "term": "PLEURAL EFFUSION",
      "count": 25
    },
    {
      "term": "WEIGHT DECREASED",
      "count": 25
    },
    {
      "term": "ACUTE KIDNEY INJURY",
      "count": 24
    },
    {
      "term": "INTENTIONAL PRODUCT USE ISSUE",
      "count": 24
    },
    {
      "term": "NEUTROPHIL COUNT DECREASED",
      "count": 24
    },
    {
      "term": "PULMONARY EMBOLISM",
      "count": 24
    },
    {
      "term": "SWELLING FACE",
      "count": 24
    },
    {
      "term": "ACUTE MYOCARDIAL INFARCTION",
      "count": 23
    },
    {
      "term": "DIZZINESS",
      "count": 23
    },
    {
      "term": "DRUG INTERACTION",
      "count": 23
    },
    {
      "term": "DRUG-INDUCED LIVER INJURY",
      "count": 23
    },
    {
      "term": "MULTIPLE SCLEROSIS",
      "count": 23
    },
    {
      "term": "NEOPLASM PROGRESSION",
      "count": 23
    },
    {
      "term": "URTICARIA",
      "count": 23
    },
    {
      "term": "ANAEMIA HAEMOLYTIC AUTOIMMUNE",
      "count": 22
    },
    {
      "term": "FALL",
      "count": 22
    },
    {
      "term": "GASTROINTESTINAL TOXICITY",
      "count": 22
    },
    {
      "term": "CYTOPENIA",
      "count": 21
    },
    {
      "term": "DRUG RESISTANCE",
      "count": 21
    },
    {
      "term": "MALAISE",
      "count": 21
    },
    {
      "term": "MUCOSAL INFLAMMATION",
      "count": 21
    },
    {
      "term": "THERAPEUTIC PRODUCT EFFECT INCOMPLETE",
      "count": 21
    },
    {
      "term": "URINARY TRACT INFECTION",
      "count": 21
    },
    {
      "term": "ABORTION SPONTANEOUS",
      "count": 20
    },
    {
      "term": "ALOPECIA",
      "count": 20
    },
    {
      "term": "BRONCHOPULMONARY ASPERGILLOSIS",
      "count": 20
    },
    {
      "term": "CYTOMEGALOVIRUS INFECTION",
      "count": 20
    },
    {
      "term": "FUNGAL INFECTION",
      "count": 20
    },
    {
      "term": "PAIN",
      "count": 20
    },
    {
      "term": "PLATELET COUNT DECREASED",
      "count": 20
    },
    {
      "term": "BACK PAIN",
      "count": 19
    },
    {
      "term": "BRADYARRHYTHMIA",
      "count": 19
    },
    {
      "term": "COGNITIVE DISORDER",
      "count": 19
    },
    {
      "term": "CUTANEOUS VASCULITIS",
      "count": 19
    }
  ]
}