{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "OFF LABEL USE",
      "count": 3874
    },
    {
      "term": "DRUG INEFFECTIVE",
      "count": 3514
    },
    {
      "term": "PYREXIA",
      "count": 2149
    },
    {
      "term": "ACUTE KIDNEY INJURY",
      "count": 1861
    },
    {
      "term": "DYSPNOEA",
      "count": 1627
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 1586
    },
    {
      "term": "PNEUMONIA",
      "count": 1420
    },
    {
      "term": "VOMITING",
      "count": 1285
    },
    {
      "term": "NAUSEA",
      "count": 1267
    },
    {
      "term": "DRUG INTERACTION",
      "count": 1185
    },
    {
      "term": "DIARRHOEA",
      "count": 1174
    },
    {
      "term": "RASH",
      "count": 1146
    },
    {
      "term": "DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS",
      "count": 1126
    },
    {
      "term": "SEPSIS",
      "count": 1090
    },
    {
      "term": "HYPOTENSION",
      "count": 1054
    },
    {
      "term": "ANAEMIA",
      "count": 976
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 967
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 911
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 905
    },
    {
      "term": "RESPIRATORY FAILURE",
      "count": 893
    },
    {
      "term": "DRUG HYPERSENSITIVITY",
      "count": 841
    },
    {
      "term": "NEUTROPENIA",
      "count": 833
    },
    {
      "term": "MULTIPLE ORGAN DYSFUNCTION SYNDROME",
      "count": 824
    },
    {
      "term": "PRURITUS",
      "count": 770
    },
    {
      "term": "COUGH",
      "count": 748
    },
    {
      "term": "SEPTIC SHOCK",
      "count": 734
    },
    {
      "term": "URTICARIA",
      "count": 726
    },
    {
      "term": "CARDIAC ARREST",
      "count": 701
    },
    {
      "term": "RENAL FAILURE",
      "count": 701
    },
    {
      "term": "GENERAL PHYSICAL HEALTH DETERIORATION",
      "count": 693
    },
    {
      "term": "DEATH",
      "count": 688
    },
    {
      "term": "EOSINOPHILIA",
      "count": 650
    },
    {
      "term": "ASTHENIA",
      "count": 620
    },
    {
      "term": "HYPONATRAEMIA",
      "count": 601
    },
    {
      "term": "FATIGUE",
      "count": 596
    },
    {
      "term": "RASH MACULO-PAPULAR",
      "count": 572
    },
    {
      "term": "ANAPHYLACTIC REACTION",
      "count": 550
    },
    {
      "term": "ERYTHEMA",
      "count": 529
    },
    {
      "term": "PAIN",
      "count": 528
    },
    {
      "term": "BLOOD CREATININE INCREASED",
      "count": 527
    },
    {
      "term": "HEADACHE",
      "count": 527
    },
    {
      "term": "CONSTIPATION",
      "count": 526
    },
    {
      "term": "ALANINE AMINOTRANSFERASE INCREASED",
      "count": 524
    },
    {
      "term": "TACHYCARDIA",
      "count": 519
    },
    {
      "term": "DRUG INEFFECTIVE FOR UNAPPROVED INDICATION",
      "count": 515
    },
    {
      "term": "PULMONARY EMBOLISM",
      "count": 506
    },
    {
      "term": "URINARY TRACT INFECTION",
      "count": 505
    },
    {
      "term": "TOXIC EPIDERMAL NECROLYSIS",
      "count": 499
    },
    {
      "term": "ELECTROCARDIOGRAM QT PROLONGED",
      "count": 498
    },
    {
      "term": "FOETAL EXPOSURE DURING PREGNANCY",
      "count": 491
    },
    {
      "term": "MATERNAL EXPOSURE DURING PREGNANCY",
      "count": 487
    },
    {
      "term": "ASPARTATE AMINOTRANSFERASE INCREASED",
      "count": 483
    },
    {
      "term": "PLEURAL EFFUSION",
      "count": 482
    },
    {
      "term": "CONFUSIONAL STATE",
      "count": 476
    },
    {
      "term": "DRUG-INDUCED LIVER INJURY",
      "count": 476
    },
    {
      "term": "SOMNOLENCE",
      "count": 474
    },
    {
      "term": "HYPOXIA",
      "count": 470
    },
    {
      "term": "RENAL FAILURE ACUTE",
      "count": 458
    },
    {
      "term": "RENAL IMPAIRMENT",
      "count": 457
    },
    {
      "term": "HYPERSENSITIVITY",
      "count": 446
    },
    {
      "term": "PANCYTOPENIA",
      "count": 444
    },
    {
      "term": "ASCITES",
      "count": 438
    },
    {
      "term": "MALAISE",
      "count": 428
    },
    {
      "term": "ABDOMINAL DISTENSION",
      "count": 425
    },
    {
      "term": "ASTHMA",
      "count": 416
    },
    {
      "term": "COVID-19",
      "count": 415
    },
    {
      "term": "OEDEMA PERIPHERAL",
      "count": 410
    },
    {
      "term": "AGRANULOCYTOSIS",
      "count": 400
    },
    {
      "term": "CHOLELITHIASIS",
      "count": 399
    },
    {
      "term": "EXPOSURE DURING PREGNANCY",
      "count": 397
    },
    {
      "term": "CARDIOGENIC SHOCK",
      "count": 393
    },
    {
      "term": "HYPERTENSION",
      "count": 392
    },
    {
      "term": "HYPOKALAEMIA",
      "count": 391
    },
    {
      "term": "WHEEZING",
      "count": 391
    },
    {
      "term": "CHEST DISCOMFORT",
      "count": 382
    },
    {
      "term": "CHOLESTASIS",
      "count": 381
    },
    {
      "term": "FEBRILE NEUTROPENIA",
      "count": 376
    },
    {
      "term": "ACUTE GENERALISED EXANTHEMATOUS PUSTULOSIS",
      "count": 371
    },
    {
      "term": "TOXICITY TO VARIOUS AGENTS",
      "count": 364
    },
    {
      "term": "DIZZINESS",
      "count": 362
    },
    {
      "term": "LEUKOPENIA",
      "count": 359
    },
    {
      "term": "STEVENS-JOHNSON SYNDROME",
      "count": 355
    },
    {
      "term": "DECREASED APPETITE",
      "count": 354
    },
    {
      "term": "INFECTION",
      "count": 353
    },
    {
      "term": "ENCEPHALOPATHY",
      "count": 352
    },
    {
      "term": "ATRIAL FIBRILLATION",
      "count": 346
    },
    {
      "term": "DISEASE PROGRESSION",
      "count": 344
    },
    {
      "term": "ANAPHYLACTIC SHOCK",
      "count": 340
    },
    {
      "term": "ARTHRALGIA",
      "count": 340
    },
    {
      "term": "ACUTE RESPIRATORY DISTRESS SYNDROME",
      "count": 339
    },
    {
      "term": "HAEMOGLOBIN DECREASED",
      "count": 337
    },
    {
      "term": "PLATELET COUNT DECREASED",
      "count": 332
    },
    {
      "term": "CHEST PAIN",
      "count": 331
    },
    {
      "term": "TUBULOINTERSTITIAL NEPHRITIS",
      "count": 331
    },
    {
      "term": "CLOSTRIDIUM DIFFICILE INFECTION",
      "count": 330
    },
    {
      "term": "PREMATURE BABY",
      "count": 327
    },
    {
      "term": "STRESS",
      "count": 326
    },
    {
      "term": "CHILLS",
      "count": 325
    },
    {
      "term": "VENTRICULAR FIBRILLATION",
      "count": 325
    },
    {
      "term": "SEIZURE",
      "count": 321
    }
  ]
}