{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "DRUG INEFFECTIVE",
      "count": 1143
    },
    {
      "term": "OFF LABEL USE",
      "count": 1008
    },
    {
      "term": "PYREXIA",
      "count": 676
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 460
    },
    {
      "term": "SEPTIC SHOCK",
      "count": 452
    },
    {
      "term": "ACUTE KIDNEY INJURY",
      "count": 395
    },
    {
      "term": "NEUTROPENIA",
      "count": 384
    },
    {
      "term": "PNEUMONIA",
      "count": 378
    },
    {
      "term": "SEPSIS",
      "count": 376
    },
    {
      "term": "DEATH",
      "count": 351
    },
    {
      "term": "DIARRHOEA",
      "count": 351
    },
    {
      "term": "FEBRILE NEUTROPENIA",
      "count": 337
    },
    {
      "term": "RESPIRATORY FAILURE",
      "count": 326
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 317
    },
    {
      "term": "HYPOTENSION",
      "count": 307
    },
    {
      "term": "DYSPNOEA",
      "count": 297
    },
    {
      "term": "NAUSEA",
      "count": 281
    },
    {
      "term": "PATHOGEN RESISTANCE",
      "count": 277
    },
    {
      "term": "MULTIPLE ORGAN DYSFUNCTION SYNDROME",
      "count": 271
    },
    {
      "term": "DRUG RESISTANCE",
      "count": 269
    },
    {
      "term": "VOMITING",
      "count": 269
    },
    {
      "term": "RENAL FAILURE",
      "count": 256
    },
    {
      "term": "ANAEMIA",
      "count": 252
    },
    {
      "term": "APLASTIC ANAEMIA",
      "count": 239
    },
    {
      "term": "RASH",
      "count": 227
    },
    {
      "term": "PLATELET COUNT DECREASED",
      "count": 221
    },
    {
      "term": "DRUG INTERACTION",
      "count": 216
    },
    {
      "term": "RENAL IMPAIRMENT",
      "count": 212
    },
    {
      "term": "PANCYTOPENIA",
      "count": 211
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 205
    },
    {
      "term": "ENDOPHTHALMITIS",
      "count": 200
    },
    {
      "term": "PSEUDOMONAS INFECTION",
      "count": 197
    },
    {
      "term": "MUCOSAL INFLAMMATION",
      "count": 194
    },
    {
      "term": "DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS",
      "count": 181
    },
    {
      "term": "ASTHENIA",
      "count": 178
    },
    {
      "term": "INFECTION",
      "count": 168
    },
    {
      "term": "RENAL FAILURE ACUTE",
      "count": 160
    },
    {
      "term": "ALANINE AMINOTRANSFERASE INCREASED",
      "count": 156
    },
    {
      "term": "DISEASE PROGRESSION",
      "count": 154
    },
    {
      "term": "DRUG INEFFECTIVE FOR UNAPPROVED INDICATION",
      "count": 154
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 153
    },
    {
      "term": "WHITE BLOOD CELL COUNT DECREASED",
      "count": 151
    },
    {
      "term": "TOXIC EPIDERMAL NECROLYSIS",
      "count": 146
    },
    {
      "term": "PAIN",
      "count": 145
    },
    {
      "term": "PRODUCT USE ISSUE",
      "count": 135
    },
    {
      "term": "CHOLESTASIS",
      "count": 134
    },
    {
      "term": "COUGH",
      "count": 133
    },
    {
      "term": "RASH MACULO-PAPULAR",
      "count": 132
    },
    {
      "term": "BLOOD CREATININE INCREASED",
      "count": 130
    },
    {
      "term": "HYPERBILIRUBINAEMIA",
      "count": 130
    },
    {
      "term": "MALAISE",
      "count": 130
    },
    {
      "term": "TOXICITY TO VARIOUS AGENTS",
      "count": 129
    },
    {
      "term": "HYPOKALAEMIA",
      "count": 127
    },
    {
      "term": "LEUKOPENIA",
      "count": 127
    },
    {
      "term": "ASPARTATE AMINOTRANSFERASE INCREASED",
      "count": 125
    },
    {
      "term": "CARDIAC ARREST",
      "count": 125
    },
    {
      "term": "DRUG HYPERSENSITIVITY",
      "count": 125
    },
    {
      "term": "PLEURAL EFFUSION",
      "count": 125
    },
    {
      "term": "DECREASED APPETITE",
      "count": 123
    },
    {
      "term": "HEADACHE",
      "count": 120
    },
    {
      "term": "HEPATIC FUNCTION ABNORMAL",
      "count": 120
    },
    {
      "term": "TREATMENT FAILURE",
      "count": 120
    },
    {
      "term": "C-REACTIVE PROTEIN INCREASED",
      "count": 119
    },
    {
      "term": "EOSINOPHILIA",
      "count": 119
    },
    {
      "term": "CONFUSIONAL STATE",
      "count": 117
    },
    {
      "term": "BLOOD BILIRUBIN INCREASED",
      "count": 116
    },
    {
      "term": "EYE PAIN",
      "count": 116
    },
    {
      "term": "ENCEPHALOPATHY",
      "count": 115
    },
    {
      "term": "HAEMOGLOBIN DECREASED",
      "count": 115
    },
    {
      "term": "DISSEMINATED INTRAVASCULAR COAGULATION",
      "count": 114
    },
    {
      "term": "WEIGHT DECREASED",
      "count": 114
    },
    {
      "term": "MULTI-ORGAN FAILURE",
      "count": 113
    },
    {
      "term": "TACHYCARDIA",
      "count": 113
    },
    {
      "term": "ASCITES",
      "count": 110
    },
    {
      "term": "GENERAL PHYSICAL HEALTH DETERIORATION",
      "count": 108
    },
    {
      "term": "CHILLS",
      "count": 107
    },
    {
      "term": "HYPERTENSION",
      "count": 107
    },
    {
      "term": "ERYTHEMA",
      "count": 106
    },
    {
      "term": "PRURITUS",
      "count": 105
    },
    {
      "term": "FATIGUE",
      "count": 101
    },
    {
      "term": "HYPOXIA",
      "count": 101
    },
    {
      "term": "HYPERSENSITIVITY",
      "count": 100
    },
    {
      "term": "VISUAL ACUITY REDUCED",
      "count": 100
    },
    {
      "term": "URINARY TRACT INFECTION",
      "count": 97
    },
    {
      "term": "NEUTROPHIL COUNT DECREASED",
      "count": 95
    },
    {
      "term": "CANDIDA INFECTION",
      "count": 93
    },
    {
      "term": "COMA",
      "count": 93
    },
    {
      "term": "GASTROINTESTINAL HAEMORRHAGE",
      "count": 91
    },
    {
      "term": "RESPIRATORY DISTRESS",
      "count": 91
    },
    {
      "term": "STAPHYLOCOCCAL INFECTION",
      "count": 90
    },
    {
      "term": "BLOOD ALKALINE PHOSPHATASE INCREASED",
      "count": 89
    },
    {
      "term": "CARDIAC FAILURE",
      "count": 89
    },
    {
      "term": "OEDEMA PERIPHERAL",
      "count": 88
    },
    {
      "term": "ACUTE RESPIRATORY DISTRESS SYNDROME",
      "count": 87
    },
    {
      "term": "SHOCK",
      "count": 87
    },
    {
      "term": "GAMMA-GLUTAMYLTRANSFERASE INCREASED",
      "count": 85
    },
    {
      "term": "HEPATIC FAILURE",
      "count": 85
    },
    {
      "term": "HYPONATRAEMIA",
      "count": 84
    },
    {
      "term": "DELIRIUM",
      "count": 82
    },
    {
      "term": "CLOSTRIDIUM DIFFICILE COLITIS",
      "count": 81
    }
  ]
}