{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "DRUG INEFFECTIVE",
      "count": 1576
    },
    {
      "term": "ACUTE KIDNEY INJURY",
      "count": 1303
    },
    {
      "term": "OFF LABEL USE",
      "count": 1185
    },
    {
      "term": "PYREXIA",
      "count": 1157
    },
    {
      "term": "FEBRILE NEUTROPENIA",
      "count": 929
    },
    {
      "term": "PNEUMONIA",
      "count": 861
    },
    {
      "term": "SEPSIS",
      "count": 662
    },
    {
      "term": "HYPOTENSION",
      "count": 613
    },
    {
      "term": "NEUTROPENIA",
      "count": 598
    },
    {
      "term": "ENCEPHALOPATHY",
      "count": 593
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 566
    },
    {
      "term": "DIARRHOEA",
      "count": 523
    },
    {
      "term": "SEPTIC SHOCK",
      "count": 520
    },
    {
      "term": "RESPIRATORY FAILURE",
      "count": 497
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 489
    },
    {
      "term": "CONFUSIONAL STATE",
      "count": 456
    },
    {
      "term": "ANAEMIA",
      "count": 436
    },
    {
      "term": "RASH",
      "count": 434
    },
    {
      "term": "NAUSEA",
      "count": 428
    },
    {
      "term": "RENAL FAILURE",
      "count": 414
    },
    {
      "term": "DYSPNOEA",
      "count": 408
    },
    {
      "term": "DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS",
      "count": 394
    },
    {
      "term": "DEATH",
      "count": 376
    },
    {
      "term": "MULTIPLE ORGAN DYSFUNCTION SYNDROME",
      "count": 363
    },
    {
      "term": "DRUG INTERACTION",
      "count": 355
    },
    {
      "term": "VOMITING",
      "count": 347
    },
    {
      "term": "PLATELET COUNT DECREASED",
      "count": 342
    },
    {
      "term": "PANCYTOPENIA",
      "count": 339
    },
    {
      "term": "CYTOKINE RELEASE SYNDROME",
      "count": 335
    },
    {
      "term": "NEUROTOXICITY",
      "count": 325
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 323
    },
    {
      "term": "BLOOD CREATININE INCREASED",
      "count": 298
    },
    {
      "term": "MENTAL STATUS CHANGES",
      "count": 298
    },
    {
      "term": "HYPOXIA",
      "count": 297
    },
    {
      "term": "RENAL IMPAIRMENT",
      "count": 285
    },
    {
      "term": "WHITE BLOOD CELL COUNT DECREASED",
      "count": 284
    },
    {
      "term": "PLEURAL EFFUSION",
      "count": 269
    },
    {
      "term": "TACHYCARDIA",
      "count": 260
    },
    {
      "term": "ASTHENIA",
      "count": 256
    },
    {
      "term": "CARDIAC ARREST",
      "count": 255
    },
    {
      "term": "FATIGUE",
      "count": 254
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 247
    },
    {
      "term": "ASPARTATE AMINOTRANSFERASE INCREASED",
      "count": 245
    },
    {
      "term": "RENAL FAILURE ACUTE",
      "count": 243
    },
    {
      "term": "ALANINE AMINOTRANSFERASE INCREASED",
      "count": 239
    },
    {
      "term": "DRUG INEFFECTIVE FOR UNAPPROVED INDICATION",
      "count": 229
    },
    {
      "term": "NEUTROPHIL COUNT DECREASED",
      "count": 226
    },
    {
      "term": "TOXICITY TO VARIOUS AGENTS",
      "count": 225
    },
    {
      "term": "ATRIAL FIBRILLATION",
      "count": 218
    },
    {
      "term": "COUGH",
      "count": 217
    },
    {
      "term": "DRUG HYPERSENSITIVITY",
      "count": 216
    },
    {
      "term": "HAEMOGLOBIN DECREASED",
      "count": 207
    },
    {
      "term": "INFECTION",
      "count": 204
    },
    {
      "term": "PAIN",
      "count": 201
    },
    {
      "term": "TUBULOINTERSTITIAL NEPHRITIS",
      "count": 201
    },
    {
      "term": "LEUKOPENIA",
      "count": 198
    },
    {
      "term": "DRUG RESISTANCE",
      "count": 197
    },
    {
      "term": "HEADACHE",
      "count": 197
    },
    {
      "term": "ACUTE RESPIRATORY DISTRESS SYNDROME",
      "count": 191
    },
    {
      "term": "URINARY TRACT INFECTION",
      "count": 191
    },
    {
      "term": "STATUS EPILEPTICUS",
      "count": 190
    },
    {
      "term": "ACUTE RESPIRATORY FAILURE",
      "count": 184
    },
    {
      "term": "CLOSTRIDIUM DIFFICILE COLITIS",
      "count": 184
    },
    {
      "term": "HYPERTENSION",
      "count": 184
    },
    {
      "term": "PRURITUS",
      "count": 183
    },
    {
      "term": "DECREASED APPETITE",
      "count": 180
    },
    {
      "term": "ACUTE GENERALISED EXANTHEMATOUS PUSTULOSIS",
      "count": 176
    },
    {
      "term": "MYOCLONUS",
      "count": 175
    },
    {
      "term": "DISEASE PROGRESSION",
      "count": 173
    },
    {
      "term": "STAPHYLOCOCCAL INFECTION",
      "count": 169
    },
    {
      "term": "BACTERAEMIA",
      "count": 165
    },
    {
      "term": "RENAL TUBULAR NECROSIS",
      "count": 164
    },
    {
      "term": "CONSTIPATION",
      "count": 160
    },
    {
      "term": "ERYTHEMA",
      "count": 160
    },
    {
      "term": "HYPOKALAEMIA",
      "count": 159
    },
    {
      "term": "EOSINOPHILIA",
      "count": 158
    },
    {
      "term": "COVID-19",
      "count": 157
    },
    {
      "term": "CHILLS",
      "count": 156
    },
    {
      "term": "SEIZURE",
      "count": 156
    },
    {
      "term": "GENERAL PHYSICAL HEALTH DETERIORATION",
      "count": 151
    },
    {
      "term": "CELLULITIS",
      "count": 150
    },
    {
      "term": "FALL",
      "count": 149
    },
    {
      "term": "RESPIRATORY DISTRESS",
      "count": 149
    },
    {
      "term": "DELIRIUM",
      "count": 146
    },
    {
      "term": "DRUG-INDUCED LIVER INJURY",
      "count": 146
    },
    {
      "term": "CLOSTRIDIUM DIFFICILE INFECTION",
      "count": 145
    },
    {
      "term": "DEHYDRATION",
      "count": 145
    },
    {
      "term": "DISSEMINATED INTRAVASCULAR COAGULATION",
      "count": 144
    },
    {
      "term": "LACTIC ACIDOSIS",
      "count": 144
    },
    {
      "term": "RASH MACULO-PAPULAR",
      "count": 144
    },
    {
      "term": "GASTROINTESTINAL HAEMORRHAGE",
      "count": 143
    },
    {
      "term": "SOMNOLENCE",
      "count": 140
    },
    {
      "term": "SHOCK",
      "count": 139
    },
    {
      "term": "METABOLIC ACIDOSIS",
      "count": 138
    },
    {
      "term": "PSEUDOMONAS INFECTION",
      "count": 137
    },
    {
      "term": "LEUKOCYTOSIS",
      "count": 136
    },
    {
      "term": "CANDIDA INFECTION",
      "count": 135
    },
    {
      "term": "OVERDOSE",
      "count": 135
    },
    {
      "term": "UNRESPONSIVE TO STIMULI",
      "count": 134
    },
    {
      "term": "PATHOGEN RESISTANCE",
      "count": 133
    }
  ]
}