{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "MALIGNANT NEOPLASM PROGRESSION",
      "count": 82
    },
    {
      "term": "DEATH",
      "count": 66
    },
    {
      "term": "OEDEMA PERIPHERAL",
      "count": 57
    },
    {
      "term": "NON-SMALL CELL LUNG CANCER",
      "count": 50
    },
    {
      "term": "NAUSEA",
      "count": 25
    },
    {
      "term": "OEDEMA",
      "count": 23
    },
    {
      "term": "DYSPNOEA",
      "count": 18
    },
    {
      "term": "PYREXIA",
      "count": 17
    },
    {
      "term": "DIARRHOEA",
      "count": 16
    },
    {
      "term": "DISEASE PROGRESSION",
      "count": 16
    },
    {
      "term": "FATIGUE",
      "count": 15
    },
    {
      "term": "DRUG INEFFECTIVE",
      "count": 14
    },
    {
      "term": "PNEUMONITIS",
      "count": 14
    },
    {
      "term": "BLOOD CREATININE INCREASED",
      "count": 13
    },
    {
      "term": "DECREASED APPETITE",
      "count": 13
    },
    {
      "term": "GENERALISED OEDEMA",
      "count": 13
    },
    {
      "term": "OFF LABEL USE",
      "count": 13
    },
    {
      "term": "ASTHENIA",
      "count": 12
    },
    {
      "term": "DRUG RESISTANCE",
      "count": 12
    },
    {
      "term": "GENERAL PHYSICAL HEALTH DETERIORATION",
      "count": 12
    },
    {
      "term": "HEPATIC CYTOLYSIS",
      "count": 12
    },
    {
      "term": "HEPATOTOXICITY",
      "count": 12
    },
    {
      "term": "METASTASES TO CENTRAL NERVOUS SYSTEM",
      "count": 12
    },
    {
      "term": "VOMITING",
      "count": 12
    },
    {
      "term": "ALANINE AMINOTRANSFERASE INCREASED",
      "count": 10
    },
    {
      "term": "PLEURAL EFFUSION",
      "count": 10
    },
    {
      "term": "PULMONARY EMBOLISM",
      "count": 10
    },
    {
      "term": "ACUTE KIDNEY INJURY",
      "count": 9
    },
    {
      "term": "COVID-19",
      "count": 9
    },
    {
      "term": "DRUG-INDUCED LIVER INJURY",
      "count": 9
    },
    {
      "term": "HEPATITIS",
      "count": 9
    },
    {
      "term": "RASH",
      "count": 9
    },
    {
      "term": "ASPARTATE AMINOTRANSFERASE INCREASED",
      "count": 8
    },
    {
      "term": "DRUG INTOLERANCE",
      "count": 8
    },
    {
      "term": "ACQUIRED GENE MUTATION",
      "count": 7
    },
    {
      "term": "COUGH",
      "count": 7
    },
    {
      "term": "DRUG INTERACTION",
      "count": 7
    },
    {
      "term": "NEOPLASM PROGRESSION",
      "count": 7
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 7
    },
    {
      "term": "RENAL FAILURE",
      "count": 7
    },
    {
      "term": "RESPIRATORY FAILURE",
      "count": 7
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 6
    },
    {
      "term": "ANAEMIA",
      "count": 6
    },
    {
      "term": "CHEST PAIN",
      "count": 6
    },
    {
      "term": "LUNG ADENOCARCINOMA",
      "count": 6
    },
    {
      "term": "PERIPHERAL SWELLING",
      "count": 6
    },
    {
      "term": "PNEUMONIA",
      "count": 6
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 6
    },
    {
      "term": "ASCITES",
      "count": 5
    },
    {
      "term": "CONFUSIONAL STATE",
      "count": 5
    },
    {
      "term": "DEHYDRATION",
      "count": 5
    },
    {
      "term": "HYPONATRAEMIA",
      "count": 5
    },
    {
      "term": "METASTASES TO BONE",
      "count": 5
    },
    {
      "term": "PAIN",
      "count": 5
    },
    {
      "term": "SEPSIS",
      "count": 5
    },
    {
      "term": "THERAPY PARTIAL RESPONDER",
      "count": 5
    },
    {
      "term": "BLOOD ALBUMIN DECREASED",
      "count": 4
    },
    {
      "term": "BLOOD SODIUM DECREASED",
      "count": 4
    },
    {
      "term": "CARDIAC FAILURE",
      "count": 4
    },
    {
      "term": "CHILLS",
      "count": 4
    },
    {
      "term": "GYNAECOMASTIA",
      "count": 4
    },
    {
      "term": "INTERSTITIAL LUNG DISEASE",
      "count": 4
    },
    {
      "term": "LIVER DISORDER",
      "count": 4
    },
    {
      "term": "LUNG NEOPLASM MALIGNANT",
      "count": 4
    },
    {
      "term": "NON-SMALL CELL LUNG CANCER METASTATIC",
      "count": 4
    },
    {
      "term": "WEIGHT INCREASED",
      "count": 4
    },
    {
      "term": "ADENOCARCINOMA",
      "count": 3
    },
    {
      "term": "BLOOD BILIRUBIN INCREASED",
      "count": 3
    },
    {
      "term": "CENTRAL NERVOUS SYSTEM LESION",
      "count": 3
    },
    {
      "term": "CEREBROVASCULAR ACCIDENT",
      "count": 3
    },
    {
      "term": "DIZZINESS",
      "count": 3
    },
    {
      "term": "DYSPHAGIA",
      "count": 3
    },
    {
      "term": "GAIT DISTURBANCE",
      "count": 3
    },
    {
      "term": "GENE MUTATION",
      "count": 3
    },
    {
      "term": "HAEMOGLOBIN DECREASED",
      "count": 3
    },
    {
      "term": "HEPATIC ENZYME INCREASED",
      "count": 3
    },
    {
      "term": "HEPATIC FUNCTION ABNORMAL",
      "count": 3
    },
    {
      "term": "HYPOALBUMINAEMIA",
      "count": 3
    },
    {
      "term": "HYPOTENSION",
      "count": 3
    },
    {
      "term": "LIVER INJURY",
      "count": 3
    },
    {
      "term": "LYMPHOEDEMA",
      "count": 3
    },
    {
      "term": "METASTASES TO LIVER",
      "count": 3
    },
    {
      "term": "METASTASES TO LUNG",
      "count": 3
    },
    {
      "term": "PERFORMANCE STATUS DECREASED",
      "count": 3
    },
    {
      "term": "PRODUCT SUPPLY ISSUE",
      "count": 3
    },
    {
      "term": "RASH MACULO-PAPULAR",
      "count": 3
    },
    {
      "term": "THERAPY NON-RESPONDER",
      "count": 3
    },
    {
      "term": "TRANSAMINASES INCREASED",
      "count": 3
    },
    {
      "term": "ABDOMINAL PAIN UPPER",
      "count": 2
    },
    {
      "term": "AGITATION",
      "count": 2
    },
    {
      "term": "AMYLASE INCREASED",
      "count": 2
    },
    {
      "term": "ATELECTASIS",
      "count": 2
    },
    {
      "term": "ATRIAL FIBRILLATION",
      "count": 2
    },
    {
      "term": "AZOTAEMIA",
      "count": 2
    },
    {
      "term": "BACK PAIN",
      "count": 2
    },
    {
      "term": "BLOOD ALKALINE PHOSPHATASE INCREASED",
      "count": 2
    },
    {
      "term": "BRAIN OEDEMA",
      "count": 2
    },
    {
      "term": "CARDIOMYOPATHY",
      "count": 2
    },
    {
      "term": "CELLULITIS",
      "count": 2
    },
    {
      "term": "CHOLESTASIS",
      "count": 2
    }
  ]
}