{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "DIARRHOEA",
      "count": 8657
    },
    {
      "term": "NAUSEA",
      "count": 5401
    },
    {
      "term": "DEATH",
      "count": 4842
    },
    {
      "term": "PALMAR-PLANTAR ERYTHRODYSAESTHESIA SYNDROME",
      "count": 4344
    },
    {
      "term": "VOMITING",
      "count": 4159
    },
    {
      "term": "DISEASE PROGRESSION",
      "count": 4056
    },
    {
      "term": "FATIGUE",
      "count": 4027
    },
    {
      "term": "MALIGNANT NEOPLASM PROGRESSION",
      "count": 2848
    },
    {
      "term": "OFF LABEL USE",
      "count": 2540
    },
    {
      "term": "NEUTROPENIA",
      "count": 2517
    },
    {
      "term": "ASTHENIA",
      "count": 2239
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 2082
    },
    {
      "term": "NEUROPATHY PERIPHERAL",
      "count": 2029
    },
    {
      "term": "DECREASED APPETITE",
      "count": 2009
    },
    {
      "term": "DEHYDRATION",
      "count": 1885
    },
    {
      "term": "DRUG INEFFECTIVE",
      "count": 1882
    },
    {
      "term": "ANAEMIA",
      "count": 1805
    },
    {
      "term": "DYSPNOEA",
      "count": 1680
    },
    {
      "term": "PYREXIA",
      "count": 1653
    },
    {
      "term": "MUCOSAL INFLAMMATION",
      "count": 1512
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 1509
    },
    {
      "term": "RASH",
      "count": 1278
    },
    {
      "term": "STOMATITIS",
      "count": 1277
    },
    {
      "term": "METASTASES TO LIVER",
      "count": 1198
    },
    {
      "term": "WEIGHT DECREASED",
      "count": 1163
    },
    {
      "term": "PAIN",
      "count": 1158
    },
    {
      "term": "CONSTIPATION",
      "count": 1073
    },
    {
      "term": "MALAISE",
      "count": 1060
    },
    {
      "term": "PAIN IN EXTREMITY",
      "count": 1001
    },
    {
      "term": "DIZZINESS",
      "count": 973
    },
    {
      "term": "MYELOSUPPRESSION",
      "count": 967
    },
    {
      "term": "LEUKOPENIA",
      "count": 944
    },
    {
      "term": "PNEUMONIA",
      "count": 938
    },
    {
      "term": "HEADACHE",
      "count": 937
    },
    {
      "term": "SEPSIS",
      "count": 926
    },
    {
      "term": "FEBRILE NEUTROPENIA",
      "count": 908
    },
    {
      "term": "PARAESTHESIA",
      "count": 904
    },
    {
      "term": "NEOPLASM PROGRESSION",
      "count": 877
    },
    {
      "term": "TOXICITY TO VARIOUS AGENTS",
      "count": 865
    },
    {
      "term": "THERAPY INTERRUPTED",
      "count": 862
    },
    {
      "term": "METASTASES TO BONE",
      "count": 844
    },
    {
      "term": "PLATELET COUNT DECREASED",
      "count": 826
    },
    {
      "term": "BREAST CANCER METASTATIC",
      "count": 809
    },
    {
      "term": "PULMONARY EMBOLISM",
      "count": 801
    },
    {
      "term": "HOSPITALISATION",
      "count": 795
    },
    {
      "term": "GENERAL PHYSICAL HEALTH DETERIORATION",
      "count": 790
    },
    {
      "term": "HYPERTENSION",
      "count": 780
    },
    {
      "term": "ERYTHEMA",
      "count": 762
    },
    {
      "term": "HYPOKALAEMIA",
      "count": 762
    },
    {
      "term": "THERAPY CESSATION",
      "count": 732
    },
    {
      "term": "WHITE BLOOD CELL COUNT DECREASED",
      "count": 727
    },
    {
      "term": "CHEST PAIN",
      "count": 723
    },
    {
      "term": "METASTASES TO CENTRAL NERVOUS SYSTEM",
      "count": 705
    },
    {
      "term": "INFECTION",
      "count": 696
    },
    {
      "term": "SKIN EXFOLIATION",
      "count": 695
    },
    {
      "term": "NEUROTOXICITY",
      "count": 692
    },
    {
      "term": "METASTASES TO LUNG",
      "count": 673
    },
    {
      "term": "HYPOAESTHESIA",
      "count": 668
    },
    {
      "term": "COUGH",
      "count": 632
    },
    {
      "term": "ABDOMINAL PAIN UPPER",
      "count": 626
    },
    {
      "term": "HYPOTENSION",
      "count": 624
    },
    {
      "term": "FALL",
      "count": 604
    },
    {
      "term": "PLEURAL EFFUSION",
      "count": 600
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 594
    },
    {
      "term": "DRY SKIN",
      "count": 586
    },
    {
      "term": "ALOPECIA",
      "count": 583
    },
    {
      "term": "BREAST CANCER",
      "count": 562
    },
    {
      "term": "BACK PAIN",
      "count": 544
    },
    {
      "term": "ASCITES",
      "count": 535
    },
    {
      "term": "DRUG INTOLERANCE",
      "count": 528
    },
    {
      "term": "ACUTE KIDNEY INJURY",
      "count": 512
    },
    {
      "term": "COLITIS",
      "count": 505
    },
    {
      "term": "URINARY TRACT INFECTION",
      "count": 502
    },
    {
      "term": "ARTHRALGIA",
      "count": 496
    },
    {
      "term": "DYSPHAGIA",
      "count": 496
    },
    {
      "term": "ARTERIOSPASM CORONARY",
      "count": 495
    },
    {
      "term": "SKIN DISCOLOURATION",
      "count": 490
    },
    {
      "term": "PANCYTOPENIA",
      "count": 477
    },
    {
      "term": "PRURITUS",
      "count": 474
    },
    {
      "term": "RENAL FAILURE",
      "count": 474
    },
    {
      "term": "THROMBOSIS",
      "count": 469
    },
    {
      "term": "INTESTINAL OBSTRUCTION",
      "count": 465
    },
    {
      "term": "GASTROINTESTINAL DISORDER",
      "count": 464
    },
    {
      "term": "BLOOD BILIRUBIN INCREASED",
      "count": 461
    },
    {
      "term": "HYPERSENSITIVITY",
      "count": 456
    },
    {
      "term": "PERIPHERAL SWELLING",
      "count": 456
    },
    {
      "term": "HAEMOGLOBIN DECREASED",
      "count": 455
    },
    {
      "term": "GASTROINTESTINAL TOXICITY",
      "count": 445
    },
    {
      "term": "MUSCLE SPASMS",
      "count": 441
    },
    {
      "term": "THERAPY PARTIAL RESPONDER",
      "count": 438
    },
    {
      "term": "ENTERITIS",
      "count": 419
    },
    {
      "term": "DEEP VEIN THROMBOSIS",
      "count": 415
    },
    {
      "term": "ALANINE AMINOTRANSFERASE INCREASED",
      "count": 414
    },
    {
      "term": "CARDIAC ARREST",
      "count": 411
    },
    {
      "term": "CONFUSIONAL STATE",
      "count": 411
    },
    {
      "term": "ASPARTATE AMINOTRANSFERASE INCREASED",
      "count": 410
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 410
    },
    {
      "term": "NEUTROPHIL COUNT DECREASED",
      "count": 406
    },
    {
      "term": "OEDEMA PERIPHERAL",
      "count": 401
    },
    {
      "term": "HEPATIC FUNCTION ABNORMAL",
      "count": 396
    }
  ]
}