{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "DIARRHOEA",
      "count": 519
    },
    {
      "term": "NAUSEA",
      "count": 415
    },
    {
      "term": "NEUTROPENIA",
      "count": 395
    },
    {
      "term": "VOMITING",
      "count": 304
    },
    {
      "term": "PYREXIA",
      "count": 285
    },
    {
      "term": "FATIGUE",
      "count": 277
    },
    {
      "term": "NEUROPATHY PERIPHERAL",
      "count": 244
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 238
    },
    {
      "term": "FEBRILE NEUTROPENIA",
      "count": 212
    },
    {
      "term": "DEATH",
      "count": 210
    },
    {
      "term": "OFF LABEL USE",
      "count": 210
    },
    {
      "term": "BONE MARROW FAILURE",
      "count": 198
    },
    {
      "term": "ANAEMIA",
      "count": 177
    },
    {
      "term": "HYPERTENSION",
      "count": 173
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 167
    },
    {
      "term": "DISEASE PROGRESSION",
      "count": 160
    },
    {
      "term": "ASTHENIA",
      "count": 159
    },
    {
      "term": "MUCOSAL INFLAMMATION",
      "count": 144
    },
    {
      "term": "SEPSIS",
      "count": 133
    },
    {
      "term": "DYSPNOEA",
      "count": 130
    },
    {
      "term": "DECREASED APPETITE",
      "count": 129
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 117
    },
    {
      "term": "RASH",
      "count": 116
    },
    {
      "term": "PULMONARY EMBOLISM",
      "count": 113
    },
    {
      "term": "LEUKOPENIA",
      "count": 112
    },
    {
      "term": "GENERAL PHYSICAL HEALTH DETERIORATION",
      "count": 109
    },
    {
      "term": "NEUROTOXICITY",
      "count": 108
    },
    {
      "term": "PAIN",
      "count": 108
    },
    {
      "term": "MALIGNANT NEOPLASM PROGRESSION",
      "count": 105
    },
    {
      "term": "PALMAR-PLANTAR ERYTHRODYSAESTHESIA SYNDROME",
      "count": 105
    },
    {
      "term": "NEOPLASM PROGRESSION",
      "count": 104
    },
    {
      "term": "WHITE BLOOD CELL COUNT DECREASED",
      "count": 104
    },
    {
      "term": "PNEUMONIA",
      "count": 103
    },
    {
      "term": "PANCYTOPENIA",
      "count": 102
    },
    {
      "term": "DRUG INEFFECTIVE",
      "count": 100
    },
    {
      "term": "ERYTHEMA",
      "count": 100
    },
    {
      "term": "ACUTE KIDNEY INJURY",
      "count": 96
    },
    {
      "term": "GASTROINTESTINAL DISORDER",
      "count": 96
    },
    {
      "term": "MALAISE",
      "count": 96
    },
    {
      "term": "NEUTROPHIL COUNT DECREASED",
      "count": 96
    },
    {
      "term": "STOMATITIS",
      "count": 96
    },
    {
      "term": "CHILLS",
      "count": 92
    },
    {
      "term": "HYPERSENSITIVITY",
      "count": 89
    },
    {
      "term": "HEADACHE",
      "count": 86
    },
    {
      "term": "DEHYDRATION",
      "count": 83
    },
    {
      "term": "HYPOTENSION",
      "count": 82
    },
    {
      "term": "RENAL FAILURE",
      "count": 80
    },
    {
      "term": "PLATELET COUNT DECREASED",
      "count": 77
    },
    {
      "term": "TOXICITY TO VARIOUS AGENTS",
      "count": 73
    },
    {
      "term": "DRUG INTERACTION",
      "count": 72
    },
    {
      "term": "PARAESTHESIA",
      "count": 72
    },
    {
      "term": "ALOPECIA",
      "count": 71
    },
    {
      "term": "CONSTIPATION",
      "count": 71
    },
    {
      "term": "INTERSTITIAL LUNG DISEASE",
      "count": 71
    },
    {
      "term": "MYELOSUPPRESSION",
      "count": 68
    },
    {
      "term": "INTESTINAL OBSTRUCTION",
      "count": 64
    },
    {
      "term": "BACTERIAL INFECTION",
      "count": 62
    },
    {
      "term": "COUGH",
      "count": 62
    },
    {
      "term": "HYPOKALAEMIA",
      "count": 62
    },
    {
      "term": "PROTEINURIA",
      "count": 61
    },
    {
      "term": "EPISTAXIS",
      "count": 60
    },
    {
      "term": "PRURITUS",
      "count": 59
    },
    {
      "term": "WEIGHT DECREASED",
      "count": 59
    },
    {
      "term": "INFECTION",
      "count": 58
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 56
    },
    {
      "term": "ASCITES",
      "count": 55
    },
    {
      "term": "SEPTIC SHOCK",
      "count": 55
    },
    {
      "term": "ARTHRALGIA",
      "count": 54
    },
    {
      "term": "MUSCULAR WEAKNESS",
      "count": 53
    },
    {
      "term": "CONFUSIONAL STATE",
      "count": 52
    },
    {
      "term": "BLOOD CREATININE INCREASED",
      "count": 51
    },
    {
      "term": "URINARY TRACT INFECTION",
      "count": 51
    },
    {
      "term": "HAEMOGLOBIN DECREASED",
      "count": 50
    },
    {
      "term": "BACK PAIN",
      "count": 49
    },
    {
      "term": "DIZZINESS",
      "count": 48
    },
    {
      "term": "HEPATIC FUNCTION ABNORMAL",
      "count": 48
    },
    {
      "term": "ABDOMINAL PAIN UPPER",
      "count": 47
    },
    {
      "term": "TACHYCARDIA",
      "count": 46
    },
    {
      "term": "OEDEMA PERIPHERAL",
      "count": 45
    },
    {
      "term": "CHEST PAIN",
      "count": 44
    },
    {
      "term": "ENCEPHALOPATHY",
      "count": 44
    },
    {
      "term": "HYPOAESTHESIA",
      "count": 44
    },
    {
      "term": "PAIN IN EXTREMITY",
      "count": 44
    },
    {
      "term": "ENTERITIS",
      "count": 43
    },
    {
      "term": "SKIN TOXICITY",
      "count": 43
    },
    {
      "term": "VIRAL INFECTION",
      "count": 43
    },
    {
      "term": "GAIT DISTURBANCE",
      "count": 42
    },
    {
      "term": "HYPERHIDROSIS",
      "count": 42
    },
    {
      "term": "PLEURAL EFFUSION",
      "count": 42
    },
    {
      "term": "ALANINE AMINOTRANSFERASE INCREASED",
      "count": 41
    },
    {
      "term": "DERMATITIS ACNEIFORM",
      "count": 41
    },
    {
      "term": "DRUG HYPERSENSITIVITY",
      "count": 41
    },
    {
      "term": "GASTROINTESTINAL HAEMORRHAGE",
      "count": 41
    },
    {
      "term": "METASTASES TO LIVER",
      "count": 41
    },
    {
      "term": "RENAL IMPAIRMENT",
      "count": 41
    },
    {
      "term": "RESPIRATORY FAILURE",
      "count": 41
    },
    {
      "term": "POLYNEUROPATHY",
      "count": 40
    },
    {
      "term": "RENAL FAILURE ACUTE",
      "count": 40
    },
    {
      "term": "SECONDARY IMMUNODEFICIENCY",
      "count": 40
    },
    {
      "term": "ASPARTATE AMINOTRANSFERASE INCREASED",
      "count": 39
    }
  ]
}