{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "DRUG INEFFECTIVE",
      "count": 90
    },
    {
      "term": "OFF LABEL USE",
      "count": 62
    },
    {
      "term": "DISEASE PROGRESSION",
      "count": 39
    },
    {
      "term": "DEATH",
      "count": 35
    },
    {
      "term": "FATIGUE",
      "count": 31
    },
    {
      "term": "PRURITUS",
      "count": 28
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 22
    },
    {
      "term": "CUTANEOUS T-CELL LYMPHOMA",
      "count": 21
    },
    {
      "term": "MALIGNANT NEOPLASM PROGRESSION",
      "count": 20
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 19
    },
    {
      "term": "NAUSEA",
      "count": 19
    },
    {
      "term": "HYPERTRIGLYCERIDAEMIA",
      "count": 18
    },
    {
      "term": "SEPTIC SHOCK",
      "count": 17
    },
    {
      "term": "DIFFUSE LARGE B-CELL LYMPHOMA",
      "count": 15
    },
    {
      "term": "HYPOTHYROIDISM",
      "count": 15
    },
    {
      "term": "PYREXIA",
      "count": 15
    },
    {
      "term": "DIARRHOEA",
      "count": 14
    },
    {
      "term": "PAIN",
      "count": 14
    },
    {
      "term": "PNEUMONIA",
      "count": 14
    },
    {
      "term": "MULTIPLE ORGAN DYSFUNCTION SYNDROME",
      "count": 13
    },
    {
      "term": "MYCOSIS FUNGOIDES",
      "count": 13
    },
    {
      "term": "NEUTROPENIA",
      "count": 13
    },
    {
      "term": "ASTHENIA",
      "count": 12
    },
    {
      "term": "BLOOD CHOLESTEROL INCREASED",
      "count": 12
    },
    {
      "term": "SKIN LESION",
      "count": 12
    },
    {
      "term": "TREATMENT FAILURE",
      "count": 12
    },
    {
      "term": "HEADACHE",
      "count": 11
    },
    {
      "term": "RASH",
      "count": 11
    },
    {
      "term": "DYSPNOEA",
      "count": 10
    },
    {
      "term": "LYMPHADENOPATHY",
      "count": 10
    },
    {
      "term": "THERAPY CESSATION",
      "count": 10
    },
    {
      "term": "WEIGHT DECREASED",
      "count": 10
    },
    {
      "term": "WHITE BLOOD CELL COUNT DECREASED",
      "count": 10
    },
    {
      "term": "ANAEMIA",
      "count": 9
    },
    {
      "term": "BLOOD TRIGLYCERIDES INCREASED",
      "count": 9
    },
    {
      "term": "CUTANEOUS T-CELL LYMPHOMA STAGE I",
      "count": 9
    },
    {
      "term": "DIZZINESS",
      "count": 9
    },
    {
      "term": "DRUG INEFFECTIVE FOR UNAPPROVED INDICATION",
      "count": 9
    },
    {
      "term": "SKIN EXFOLIATION",
      "count": 9
    },
    {
      "term": "VENOUS THROMBOSIS",
      "count": 9
    },
    {
      "term": "VOMITING",
      "count": 9
    },
    {
      "term": "ARTHRALGIA",
      "count": 8
    },
    {
      "term": "DEHYDRATION",
      "count": 8
    },
    {
      "term": "FEELING ABNORMAL",
      "count": 8
    },
    {
      "term": "NEOPLASM PROGRESSION",
      "count": 8
    },
    {
      "term": "SEPSIS",
      "count": 8
    },
    {
      "term": "STAPHYLOCOCCAL BACTERAEMIA",
      "count": 8
    },
    {
      "term": "THERAPEUTIC RESPONSE DECREASED",
      "count": 8
    },
    {
      "term": "THERAPY INTERRUPTED",
      "count": 8
    },
    {
      "term": "ALOPECIA",
      "count": 7
    },
    {
      "term": "CHILLS",
      "count": 7
    },
    {
      "term": "CONFUSIONAL STATE",
      "count": 7
    },
    {
      "term": "CONSTIPATION",
      "count": 7
    },
    {
      "term": "DERMATITIS EXFOLIATIVE GENERALISED",
      "count": 7
    },
    {
      "term": "ECZEMA",
      "count": 7
    },
    {
      "term": "HOSPITALISATION",
      "count": 7
    },
    {
      "term": "INFECTION",
      "count": 7
    },
    {
      "term": "LEG AMPUTATION",
      "count": 7
    },
    {
      "term": "MYALGIA",
      "count": 7
    },
    {
      "term": "PRODUCT USE ISSUE",
      "count": 7
    },
    {
      "term": "SKIN PLAQUE",
      "count": 7
    },
    {
      "term": "ATRIAL FIBRILLATION",
      "count": 6
    },
    {
      "term": "CELLULITIS",
      "count": 6
    },
    {
      "term": "CHRONIC KIDNEY DISEASE",
      "count": 6
    },
    {
      "term": "CUTANEOUS T-CELL LYMPHOMA REFRACTORY",
      "count": 6
    },
    {
      "term": "DECREASED APPETITE",
      "count": 6
    },
    {
      "term": "DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS",
      "count": 6
    },
    {
      "term": "FALL",
      "count": 6
    },
    {
      "term": "FEBRILE NEUTROPENIA",
      "count": 6
    },
    {
      "term": "MUSCLE SPASMS",
      "count": 6
    },
    {
      "term": "OEDEMA PERIPHERAL",
      "count": 6
    },
    {
      "term": "PALMOPLANTAR KERATODERMA",
      "count": 6
    },
    {
      "term": "STAPHYLOCOCCAL INFECTION",
      "count": 6
    },
    {
      "term": "THERAPY NON-RESPONDER",
      "count": 6
    },
    {
      "term": "URINARY TRACT INFECTION",
      "count": 6
    },
    {
      "term": "APPLICATION SITE ERYTHEMA",
      "count": 5
    },
    {
      "term": "COUGH",
      "count": 5
    },
    {
      "term": "CUTANEOUS T-CELL LYMPHOMA RECURRENT",
      "count": 5
    },
    {
      "term": "DERMATITIS PSORIASIFORM",
      "count": 5
    },
    {
      "term": "ERYTHEMA",
      "count": 5
    },
    {
      "term": "MOUTH ULCERATION",
      "count": 5
    },
    {
      "term": "NEUROPATHY PERIPHERAL",
      "count": 5
    },
    {
      "term": "PRODUCT DOSE OMISSION",
      "count": 5
    },
    {
      "term": "PRODUCT PRESCRIBING ISSUE",
      "count": 5
    },
    {
      "term": "PRODUCT SUBSTITUTION ISSUE",
      "count": 5
    },
    {
      "term": "SOMNOLENCE",
      "count": 5
    },
    {
      "term": "SYMPTOM MASKED",
      "count": 5
    },
    {
      "term": "THERAPY PARTIAL RESPONDER",
      "count": 5
    },
    {
      "term": "THYROID STIMULATING HORMONE DEFICIENCY",
      "count": 5
    },
    {
      "term": "TRANSAMINASES INCREASED",
      "count": 5
    },
    {
      "term": "VITILIGO",
      "count": 5
    },
    {
      "term": "ABDOMINAL DISTENSION",
      "count": 4
    },
    {
      "term": "ADVERSE EVENT",
      "count": 4
    },
    {
      "term": "ANGINA UNSTABLE",
      "count": 4
    },
    {
      "term": "CEREBROVASCULAR ACCIDENT",
      "count": 4
    },
    {
      "term": "CHEST PAIN",
      "count": 4
    },
    {
      "term": "DEPRESSION",
      "count": 4
    },
    {
      "term": "DISEASE RECURRENCE",
      "count": 4
    },
    {
      "term": "DRUG DOSE OMISSION",
      "count": 4
    },
    {
      "term": "DRUG INTERACTION",
      "count": 4
    }
  ]
}