{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "OFF LABEL USE",
      "count": 6602
    },
    {
      "term": "DIARRHOEA",
      "count": 4470
    },
    {
      "term": "NAUSEA",
      "count": 3665
    },
    {
      "term": "HYPERTENSION",
      "count": 3596
    },
    {
      "term": "FATIGUE",
      "count": 3452
    },
    {
      "term": "DEATH",
      "count": 3431
    },
    {
      "term": "ANAEMIA",
      "count": 3144
    },
    {
      "term": "DISEASE PROGRESSION",
      "count": 3059
    },
    {
      "term": "NEUTROPENIA",
      "count": 2979
    },
    {
      "term": "VOMITING",
      "count": 2893
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 2416
    },
    {
      "term": "PYREXIA",
      "count": 2367
    },
    {
      "term": "PROTEINURIA",
      "count": 1941
    },
    {
      "term": "DECREASED APPETITE",
      "count": 1866
    },
    {
      "term": "DYSPNOEA",
      "count": 1805
    },
    {
      "term": "NEUROPATHY PERIPHERAL",
      "count": 1759
    },
    {
      "term": "FEBRILE NEUTROPENIA",
      "count": 1703
    },
    {
      "term": "ASTHENIA",
      "count": 1702
    },
    {
      "term": "MALIGNANT NEOPLASM PROGRESSION",
      "count": 1692
    },
    {
      "term": "DRUG INEFFECTIVE",
      "count": 1620
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 1595
    },
    {
      "term": "MYELOSUPPRESSION",
      "count": 1326
    },
    {
      "term": "DEHYDRATION",
      "count": 1305
    },
    {
      "term": "PNEUMONIA",
      "count": 1266
    },
    {
      "term": "PULMONARY EMBOLISM",
      "count": 1250
    },
    {
      "term": "PLATELET COUNT DECREASED",
      "count": 1204
    },
    {
      "term": "RASH",
      "count": 1192
    },
    {
      "term": "GENERAL PHYSICAL HEALTH DETERIORATION",
      "count": 1191
    },
    {
      "term": "CONSTIPATION",
      "count": 1110
    },
    {
      "term": "NEUTROPHIL COUNT DECREASED",
      "count": 1107
    },
    {
      "term": "EPISTAXIS",
      "count": 1087
    },
    {
      "term": "LEUKOPENIA",
      "count": 1075
    },
    {
      "term": "INTENTIONAL PRODUCT USE ISSUE",
      "count": 1063
    },
    {
      "term": "SEPSIS",
      "count": 1032
    },
    {
      "term": "HEADACHE",
      "count": 1022
    },
    {
      "term": "WHITE BLOOD CELL COUNT DECREASED",
      "count": 1021
    },
    {
      "term": "MUCOSAL INFLAMMATION",
      "count": 1017
    },
    {
      "term": "PALMAR-PLANTAR ERYTHRODYSAESTHESIA SYNDROME",
      "count": 997
    },
    {
      "term": "STOMATITIS",
      "count": 888
    },
    {
      "term": "WEIGHT DECREASED",
      "count": 860
    },
    {
      "term": "HAEMORRHAGE",
      "count": 844
    },
    {
      "term": "ACUTE KIDNEY INJURY",
      "count": 830
    },
    {
      "term": "PAIN",
      "count": 827
    },
    {
      "term": "NEOPLASM PROGRESSION",
      "count": 821
    },
    {
      "term": "THERAPY PARTIAL RESPONDER",
      "count": 810
    },
    {
      "term": "DEEP VEIN THROMBOSIS",
      "count": 777
    },
    {
      "term": "HYPOKALAEMIA",
      "count": 748
    },
    {
      "term": "ASCITES",
      "count": 743
    },
    {
      "term": "ALANINE AMINOTRANSFERASE INCREASED",
      "count": 734
    },
    {
      "term": "INFECTION",
      "count": 733
    },
    {
      "term": "ASPARTATE AMINOTRANSFERASE INCREASED",
      "count": 725
    },
    {
      "term": "PLEURAL EFFUSION",
      "count": 724
    },
    {
      "term": "HYPONATRAEMIA",
      "count": 689
    },
    {
      "term": "ALOPECIA",
      "count": 679
    },
    {
      "term": "URINARY TRACT INFECTION",
      "count": 663
    },
    {
      "term": "HYPOTENSION",
      "count": 656
    },
    {
      "term": "HAEMOGLOBIN DECREASED",
      "count": 622
    },
    {
      "term": "MALAISE",
      "count": 615
    },
    {
      "term": "DRUG EFFECTIVE FOR UNAPPROVED INDICATION",
      "count": 609
    },
    {
      "term": "METASTASES TO LIVER",
      "count": 603
    },
    {
      "term": "DIZZINESS",
      "count": 602
    },
    {
      "term": "CONFUSIONAL STATE",
      "count": 594
    },
    {
      "term": "COUGH",
      "count": 593
    },
    {
      "term": "ENDOPHTHALMITIS",
      "count": 592
    },
    {
      "term": "TOXICITY TO VARIOUS AGENTS",
      "count": 581
    },
    {
      "term": "HYPOTHYROIDISM",
      "count": 580
    },
    {
      "term": "BLOOD CREATININE INCREASED",
      "count": 564
    },
    {
      "term": "HEPATOCELLULAR CARCINOMA",
      "count": 563
    },
    {
      "term": "ARTHRALGIA",
      "count": 562
    },
    {
      "term": "NEUROTOXICITY",
      "count": 559
    },
    {
      "term": "RENAL FAILURE",
      "count": 554
    },
    {
      "term": "HYPERSENSITIVITY",
      "count": 547
    },
    {
      "term": "INTERSTITIAL LUNG DISEASE",
      "count": 544
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 543
    },
    {
      "term": "RENAL IMPAIRMENT",
      "count": 543
    },
    {
      "term": "PNEUMONITIS",
      "count": 541
    },
    {
      "term": "COLITIS",
      "count": 540
    },
    {
      "term": "GASTROINTESTINAL HAEMORRHAGE",
      "count": 537
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 522
    },
    {
      "term": "HEPATIC FUNCTION ABNORMAL",
      "count": 520
    },
    {
      "term": "INTESTINAL PERFORATION",
      "count": 515
    },
    {
      "term": "PRURITUS",
      "count": 506
    },
    {
      "term": "COLORECTAL CANCER METASTATIC",
      "count": 485
    },
    {
      "term": "BACK PAIN",
      "count": 474
    },
    {
      "term": "CHEST PAIN",
      "count": 470
    },
    {
      "term": "ATRIAL FIBRILLATION",
      "count": 469
    },
    {
      "term": "BONE MARROW FAILURE",
      "count": 458
    },
    {
      "term": "INTESTINAL OBSTRUCTION",
      "count": 457
    },
    {
      "term": "HEPATIC FAILURE",
      "count": 456
    },
    {
      "term": "RESPIRATORY FAILURE",
      "count": 456
    },
    {
      "term": "THROMBOSIS",
      "count": 456
    },
    {
      "term": "PANCYTOPENIA",
      "count": 446
    },
    {
      "term": "FALL",
      "count": 440
    },
    {
      "term": "OEDEMA PERIPHERAL",
      "count": 435
    },
    {
      "term": "CARDIAC FAILURE",
      "count": 434
    },
    {
      "term": "EMBOLISM",
      "count": 434
    },
    {
      "term": "GASTROINTESTINAL PERFORATION",
      "count": 432
    },
    {
      "term": "CEREBROVASCULAR ACCIDENT",
      "count": 431
    },
    {
      "term": "ABDOMINAL PAIN UPPER",
      "count": 429
    },
    {
      "term": "DRUG INEFFECTIVE FOR UNAPPROVED INDICATION",
      "count": 427
    }
  ]
}