{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "OFF LABEL USE",
      "count": 1041
    },
    {
      "term": "PYREXIA",
      "count": 578
    },
    {
      "term": "DISEASE PROGRESSION",
      "count": 526
    },
    {
      "term": "DRUG INEFFECTIVE",
      "count": 408
    },
    {
      "term": "COVID-19",
      "count": 406
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 403
    },
    {
      "term": "FEBRILE NEUTROPENIA",
      "count": 382
    },
    {
      "term": "NEUTROPENIA",
      "count": 374
    },
    {
      "term": "MALIGNANT NEOPLASM PROGRESSION",
      "count": 366
    },
    {
      "term": "PNEUMONIA",
      "count": 351
    },
    {
      "term": "NEUTROPHIL COUNT DECREASED",
      "count": 341
    },
    {
      "term": "PLATELET COUNT DECREASED",
      "count": 341
    },
    {
      "term": "ANAEMIA",
      "count": 316
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 281
    },
    {
      "term": "PRESCRIBED UNDERDOSE",
      "count": 279
    },
    {
      "term": "MYELOSUPPRESSION",
      "count": 265
    },
    {
      "term": "CYTOMEGALOVIRUS INFECTION",
      "count": 256
    },
    {
      "term": "DEATH",
      "count": 255
    },
    {
      "term": "DIARRHOEA",
      "count": 243
    },
    {
      "term": "PANCYTOPENIA",
      "count": 240
    },
    {
      "term": "WHITE BLOOD CELL COUNT DECREASED",
      "count": 236
    },
    {
      "term": "RASH",
      "count": 230
    },
    {
      "term": "INFUSION RELATED REACTION",
      "count": 222
    },
    {
      "term": "NAUSEA",
      "count": 213
    },
    {
      "term": "LYMPHOCYTE COUNT DECREASED",
      "count": 207
    },
    {
      "term": "SEPSIS",
      "count": 198
    },
    {
      "term": "ACUTE KIDNEY INJURY",
      "count": 194
    },
    {
      "term": "INFECTION",
      "count": 180
    },
    {
      "term": "PRODUCT USE ISSUE",
      "count": 173
    },
    {
      "term": "CYTOPENIA",
      "count": 169
    },
    {
      "term": "FATIGUE",
      "count": 168
    },
    {
      "term": "DIFFUSE LARGE B-CELL LYMPHOMA",
      "count": 165
    },
    {
      "term": "BLOOD LACTATE DEHYDROGENASE INCREASED",
      "count": 158
    },
    {
      "term": "DECREASED APPETITE",
      "count": 155
    },
    {
      "term": "HYPOTENSION",
      "count": 152
    },
    {
      "term": "NEUROPATHY PERIPHERAL",
      "count": 147
    },
    {
      "term": "COVID-19 PNEUMONIA",
      "count": 146
    },
    {
      "term": "VOMITING",
      "count": 138
    },
    {
      "term": "ASTHENIA",
      "count": 137
    },
    {
      "term": "DYSPNOEA",
      "count": 132
    },
    {
      "term": "PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY",
      "count": 127
    },
    {
      "term": "HYPOGAMMAGLOBULINAEMIA",
      "count": 121
    },
    {
      "term": "PLASMA CELL MYELOMA",
      "count": 118
    },
    {
      "term": "SEPTIC SHOCK",
      "count": 118
    },
    {
      "term": "HYPERSENSITIVITY",
      "count": 115
    },
    {
      "term": "ATRIAL FIBRILLATION",
      "count": 113
    },
    {
      "term": "CHILLS",
      "count": 107
    },
    {
      "term": "ERYTHEMA",
      "count": 102
    },
    {
      "term": "PRURITUS",
      "count": 101
    },
    {
      "term": "TUMOUR LYSIS SYNDROME",
      "count": 101
    },
    {
      "term": "THERAPY PARTIAL RESPONDER",
      "count": 100
    },
    {
      "term": "PLEURAL EFFUSION",
      "count": 95
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 94
    },
    {
      "term": "MALAISE",
      "count": 92
    },
    {
      "term": "MYELODYSPLASTIC SYNDROME",
      "count": 92
    },
    {
      "term": "END STAGE RENAL DISEASE",
      "count": 89
    },
    {
      "term": "LYMPHADENOPATHY",
      "count": 89
    },
    {
      "term": "DEHYDRATION",
      "count": 87
    },
    {
      "term": "CONSTIPATION",
      "count": 86
    },
    {
      "term": "CYTOMEGALOVIRUS CHORIORETINITIS",
      "count": 86
    },
    {
      "term": "INTENTIONAL PRODUCT USE ISSUE",
      "count": 86
    },
    {
      "term": "INTERSTITIAL LUNG DISEASE",
      "count": 86
    },
    {
      "term": "RASH MACULO-PAPULAR",
      "count": 85
    },
    {
      "term": "GENERAL PHYSICAL HEALTH DETERIORATION",
      "count": 83
    },
    {
      "term": "LYMPHOMA",
      "count": 83
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 82
    },
    {
      "term": "CYTOKINE RELEASE SYNDROME",
      "count": 81
    },
    {
      "term": "HAEMOGLOBIN DECREASED",
      "count": 81
    },
    {
      "term": "ACUTE MYELOID LEUKAEMIA",
      "count": 80
    },
    {
      "term": "LEUKOPENIA",
      "count": 80
    },
    {
      "term": "DIFFUSE LARGE B-CELL LYMPHOMA RECURRENT",
      "count": 79
    },
    {
      "term": "ALANINE AMINOTRANSFERASE INCREASED",
      "count": 78
    },
    {
      "term": "ASPARTATE AMINOTRANSFERASE INCREASED",
      "count": 78
    },
    {
      "term": "HEPATIC FUNCTION ABNORMAL",
      "count": 78
    },
    {
      "term": "LYMPHOPENIA",
      "count": 78
    },
    {
      "term": "NEOPLASM PROGRESSION",
      "count": 78
    },
    {
      "term": "BLOOD PRESSURE DECREASED",
      "count": 77
    },
    {
      "term": "DRUG INEFFECTIVE FOR UNAPPROVED INDICATION",
      "count": 77
    },
    {
      "term": "RENAL IMPAIRMENT",
      "count": 77
    },
    {
      "term": "CD4 LYMPHOCYTES DECREASED",
      "count": 76
    },
    {
      "term": "WEIGHT DECREASED",
      "count": 75
    },
    {
      "term": "RESPIRATORY FAILURE",
      "count": 73
    },
    {
      "term": "CYTOMEGALOVIRUS INFECTION REACTIVATION",
      "count": 72
    },
    {
      "term": "PNEUMOCYSTIS JIROVECII PNEUMONIA",
      "count": 72
    },
    {
      "term": "HEADACHE",
      "count": 71
    },
    {
      "term": "CORONAVIRUS INFECTION",
      "count": 69
    },
    {
      "term": "HERPES ZOSTER",
      "count": 69
    },
    {
      "term": "PAIN",
      "count": 69
    },
    {
      "term": "RENAL FAILURE",
      "count": 69
    },
    {
      "term": "CYTOMEGALOVIRUS VIRAEMIA",
      "count": 68
    },
    {
      "term": "TREATMENT FAILURE",
      "count": 68
    },
    {
      "term": "CARDIAC DISORDER",
      "count": 67
    },
    {
      "term": "COUGH",
      "count": 67
    },
    {
      "term": "CHRONIC LYMPHOCYTIC LEUKAEMIA",
      "count": 65
    },
    {
      "term": "TOXICITY TO VARIOUS AGENTS",
      "count": 65
    },
    {
      "term": "BONE MARROW FAILURE",
      "count": 64
    },
    {
      "term": "CARDIAC FAILURE",
      "count": 63
    },
    {
      "term": "C-REACTIVE PROTEIN INCREASED",
      "count": 61
    },
    {
      "term": "THERAPY NON-RESPONDER",
      "count": 60
    },
    {
      "term": "ALOPECIA",
      "count": 59
    }
  ]
}