{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "OFF LABEL USE",
      "count": 145
    },
    {
      "term": "DEATH",
      "count": 123
    },
    {
      "term": "DISEASE PROGRESSION",
      "count": 116
    },
    {
      "term": "NEOPLASM PROGRESSION",
      "count": 94
    },
    {
      "term": "DIARRHOEA",
      "count": 92
    },
    {
      "term": "FATIGUE",
      "count": 80
    },
    {
      "term": "NAUSEA",
      "count": 78
    },
    {
      "term": "PYREXIA",
      "count": 78
    },
    {
      "term": "PNEUMONITIS",
      "count": 67
    },
    {
      "term": "ACUTE KIDNEY INJURY",
      "count": 66
    },
    {
      "term": "GENERAL PHYSICAL HEALTH DETERIORATION",
      "count": 63
    },
    {
      "term": "COLITIS",
      "count": 61
    },
    {
      "term": "PNEUMONIA",
      "count": 60
    },
    {
      "term": "DYSPNOEA",
      "count": 55
    },
    {
      "term": "NEUROPATHY PERIPHERAL",
      "count": 55
    },
    {
      "term": "INFUSION RELATED REACTION",
      "count": 53
    },
    {
      "term": "ANAEMIA",
      "count": 52
    },
    {
      "term": "FEBRILE NEUTROPENIA",
      "count": 51
    },
    {
      "term": "SEPSIS",
      "count": 51
    },
    {
      "term": "RASH",
      "count": 50
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 50
    },
    {
      "term": "DRUG INEFFECTIVE",
      "count": 46
    },
    {
      "term": "HEPATITIS",
      "count": 45
    },
    {
      "term": "MALIGNANT NEOPLASM PROGRESSION",
      "count": 45
    },
    {
      "term": "MYOCARDITIS",
      "count": 43
    },
    {
      "term": "HYPOTHYROIDISM",
      "count": 42
    },
    {
      "term": "VOMITING",
      "count": 41
    },
    {
      "term": "DECREASED APPETITE",
      "count": 40
    },
    {
      "term": "SKIN TOXICITY",
      "count": 38
    },
    {
      "term": "CHILLS",
      "count": 37
    },
    {
      "term": "PRURITUS",
      "count": 36
    },
    {
      "term": "MYOSITIS",
      "count": 34
    },
    {
      "term": "NEUTROPENIA",
      "count": 34
    },
    {
      "term": "TRANSAMINASES INCREASED",
      "count": 33
    },
    {
      "term": "DEHYDRATION",
      "count": 32
    },
    {
      "term": "PULMONARY EMBOLISM",
      "count": 32
    },
    {
      "term": "HYPOTENSION",
      "count": 31
    },
    {
      "term": "ADRENAL INSUFFICIENCY",
      "count": 30
    },
    {
      "term": "ASTHENIA",
      "count": 30
    },
    {
      "term": "HYPERTENSION",
      "count": 29
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 28
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 28
    },
    {
      "term": "BACK PAIN",
      "count": 27
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 27
    },
    {
      "term": "HAEMATURIA",
      "count": 27
    },
    {
      "term": "HAEMOGLOBIN DECREASED",
      "count": 26
    },
    {
      "term": "ARTHRITIS",
      "count": 25
    },
    {
      "term": "CONSTIPATION",
      "count": 24
    },
    {
      "term": "DIZZINESS",
      "count": 24
    },
    {
      "term": "HYPERTHYROIDISM",
      "count": 23
    },
    {
      "term": "ARTHRALGIA",
      "count": 22
    },
    {
      "term": "DIABETES MELLITUS",
      "count": 22
    },
    {
      "term": "HYPONATRAEMIA",
      "count": 22
    },
    {
      "term": "MALAISE",
      "count": 22
    },
    {
      "term": "MUCOSAL INFLAMMATION",
      "count": 22
    },
    {
      "term": "URINARY TRACT INFECTION",
      "count": 22
    },
    {
      "term": "HYPERGLYCAEMIA",
      "count": 21
    },
    {
      "term": "PANCREATITIS",
      "count": 21
    },
    {
      "term": "RESPIRATORY FAILURE",
      "count": 21
    },
    {
      "term": "CONFUSIONAL STATE",
      "count": 19
    },
    {
      "term": "MYASTHENIA GRAVIS",
      "count": 19
    },
    {
      "term": "NEPHRITIS",
      "count": 19
    },
    {
      "term": "RENAL FAILURE",
      "count": 19
    },
    {
      "term": "ATRIAL FIBRILLATION",
      "count": 18
    },
    {
      "term": "CARDIAC FAILURE",
      "count": 18
    },
    {
      "term": "INTERSTITIAL LUNG DISEASE",
      "count": 18
    },
    {
      "term": "NEUTROPHIL COUNT DECREASED",
      "count": 18
    },
    {
      "term": "FALL",
      "count": 17
    },
    {
      "term": "HYPOKALAEMIA",
      "count": 17
    },
    {
      "term": "SYNCOPE",
      "count": 17
    },
    {
      "term": "WEIGHT DECREASED",
      "count": 17
    },
    {
      "term": "ALANINE AMINOTRANSFERASE INCREASED",
      "count": 16
    },
    {
      "term": "CHEST PAIN",
      "count": 16
    },
    {
      "term": "COUGH",
      "count": 16
    },
    {
      "term": "CYTOKINE RELEASE SYNDROME",
      "count": 16
    },
    {
      "term": "HEADACHE",
      "count": 16
    },
    {
      "term": "PAIN",
      "count": 16
    },
    {
      "term": "ANKYLOSING SPONDYLITIS",
      "count": 15
    },
    {
      "term": "DERMATITIS",
      "count": 15
    },
    {
      "term": "DEVICE RELATED INFECTION",
      "count": 15
    },
    {
      "term": "DYSPHAGIA",
      "count": 15
    },
    {
      "term": "ENCEPHALITIS",
      "count": 15
    },
    {
      "term": "GASTROINTESTINAL DISORDER",
      "count": 15
    },
    {
      "term": "HEPATOTOXICITY",
      "count": 15
    },
    {
      "term": "HYPOPHYSITIS",
      "count": 15
    },
    {
      "term": "LYMPHOMA TRANSFORMATION",
      "count": 15
    },
    {
      "term": "MYALGIA",
      "count": 15
    },
    {
      "term": "PLATELET COUNT DECREASED",
      "count": 15
    },
    {
      "term": "SEPTIC SHOCK",
      "count": 15
    },
    {
      "term": "VITILIGO",
      "count": 15
    },
    {
      "term": "CARDIAC ARREST",
      "count": 14
    },
    {
      "term": "INFECTION",
      "count": 14
    },
    {
      "term": "LOWER RESPIRATORY TRACT INFECTION",
      "count": 14
    },
    {
      "term": "PLEURAL EFFUSION",
      "count": 14
    },
    {
      "term": "STOMATITIS",
      "count": 14
    },
    {
      "term": "ASPARTATE AMINOTRANSFERASE INCREASED",
      "count": 13
    },
    {
      "term": "BRADYCARDIA",
      "count": 13
    },
    {
      "term": "LICHENOID KERATOSIS",
      "count": 13
    },
    {
      "term": "MUSCULAR WEAKNESS",
      "count": 13
    },
    {
      "term": "SKIN DISORDER",
      "count": 13
    }
  ]
}