{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "DRUG INEFFECTIVE",
      "count": 4258
    },
    {
      "term": "OFF LABEL USE",
      "count": 1760
    },
    {
      "term": "PYREXIA",
      "count": 834
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 833
    },
    {
      "term": "MULTIPLE ORGAN DYSFUNCTION SYNDROME",
      "count": 584
    },
    {
      "term": "ACUTE KIDNEY INJURY",
      "count": 557
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 543
    },
    {
      "term": "SEPSIS",
      "count": 506
    },
    {
      "term": "FEBRILE NEUTROPENIA",
      "count": 500
    },
    {
      "term": "SEPTIC SHOCK",
      "count": 471
    },
    {
      "term": "RESPIRATORY FAILURE",
      "count": 466
    },
    {
      "term": "PNEUMONIA",
      "count": 461
    },
    {
      "term": "NEUTROPENIA",
      "count": 445
    },
    {
      "term": "DEATH",
      "count": 443
    },
    {
      "term": "DRUG INTERACTION",
      "count": 424
    },
    {
      "term": "HYPOKALAEMIA",
      "count": 399
    },
    {
      "term": "ASPERGILLUS INFECTION",
      "count": 398
    },
    {
      "term": "RENAL IMPAIRMENT",
      "count": 398
    },
    {
      "term": "BRONCHOPULMONARY ASPERGILLOSIS",
      "count": 376
    },
    {
      "term": "ANAEMIA",
      "count": 371
    },
    {
      "term": "RENAL FAILURE",
      "count": 367
    },
    {
      "term": "DRUG RESISTANCE",
      "count": 361
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 356
    },
    {
      "term": "DRUG INEFFECTIVE FOR UNAPPROVED INDICATION",
      "count": 346
    },
    {
      "term": "NAUSEA",
      "count": 346
    },
    {
      "term": "VOMITING",
      "count": 335
    },
    {
      "term": "PANCYTOPENIA",
      "count": 332
    },
    {
      "term": "TREATMENT FAILURE",
      "count": 331
    },
    {
      "term": "GENERAL PHYSICAL HEALTH DETERIORATION",
      "count": 329
    },
    {
      "term": "HYPOTENSION",
      "count": 324
    },
    {
      "term": "DIARRHOEA",
      "count": 323
    },
    {
      "term": "MUCORMYCOSIS",
      "count": 321
    },
    {
      "term": "DISEASE PROGRESSION",
      "count": 316
    },
    {
      "term": "FUNGAL INFECTION",
      "count": 312
    },
    {
      "term": "DYSPNOEA",
      "count": 272
    },
    {
      "term": "LEUKOPENIA",
      "count": 266
    },
    {
      "term": "INFECTION",
      "count": 240
    },
    {
      "term": "BLOOD CREATININE INCREASED",
      "count": 239
    },
    {
      "term": "CANDIDA INFECTION",
      "count": 229
    },
    {
      "term": "PRODUCT USE ISSUE",
      "count": 220
    },
    {
      "term": "HEADACHE",
      "count": 218
    },
    {
      "term": "IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME",
      "count": 208
    },
    {
      "term": "NEPHROPATHY TOXIC",
      "count": 204
    },
    {
      "term": "PLEURAL EFFUSION",
      "count": 193
    },
    {
      "term": "CYTOMEGALOVIRUS INFECTION",
      "count": 190
    },
    {
      "term": "CARDIAC ARREST",
      "count": 189
    },
    {
      "term": "THERAPY NON-RESPONDER",
      "count": 185
    },
    {
      "term": "TOXICITY TO VARIOUS AGENTS",
      "count": 182
    },
    {
      "term": "TOXIC EPIDERMAL NECROLYSIS",
      "count": 176
    },
    {
      "term": "MUCOSAL INFLAMMATION",
      "count": 174
    },
    {
      "term": "RASH",
      "count": 168
    },
    {
      "term": "MENINGITIS CRYPTOCOCCAL",
      "count": 164
    },
    {
      "term": "TACHYCARDIA",
      "count": 163
    },
    {
      "term": "FATIGUE",
      "count": 160
    },
    {
      "term": "PATHOGEN RESISTANCE",
      "count": 160
    },
    {
      "term": "HYPERTENSION",
      "count": 157
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 154
    },
    {
      "term": "C-REACTIVE PROTEIN INCREASED",
      "count": 152
    },
    {
      "term": "MULTI-ORGAN FAILURE",
      "count": 152
    },
    {
      "term": "CHILLS",
      "count": 141
    },
    {
      "term": "COUGH",
      "count": 138
    },
    {
      "term": "HAEMOGLOBIN DECREASED",
      "count": 138
    },
    {
      "term": "ENDOPHTHALMITIS",
      "count": 137
    },
    {
      "term": "HEPATOTOXICITY",
      "count": 137
    },
    {
      "term": "HYPONATRAEMIA",
      "count": 135
    },
    {
      "term": "GRAFT VERSUS HOST DISEASE",
      "count": 134
    },
    {
      "term": "ACUTE RESPIRATORY DISTRESS SYNDROME",
      "count": 131
    },
    {
      "term": "HYPERKALAEMIA",
      "count": 130
    },
    {
      "term": "WEIGHT DECREASED",
      "count": 130
    },
    {
      "term": "ALANINE AMINOTRANSFERASE INCREASED",
      "count": 128
    },
    {
      "term": "CRYPTOCOCCOSIS",
      "count": 127
    },
    {
      "term": "SYSTEMIC CANDIDA",
      "count": 127
    },
    {
      "term": "STAPHYLOCOCCAL INFECTION",
      "count": 126
    },
    {
      "term": "HEPATIC FUNCTION ABNORMAL",
      "count": 124
    },
    {
      "term": "BONE MARROW FAILURE",
      "count": 123
    },
    {
      "term": "DRUG LEVEL INCREASED",
      "count": 123
    },
    {
      "term": "OEDEMA PERIPHERAL",
      "count": 123
    },
    {
      "term": "ENCEPHALOPATHY",
      "count": 122
    },
    {
      "term": "PAIN",
      "count": 121
    },
    {
      "term": "FUNGAEMIA",
      "count": 120
    },
    {
      "term": "METABOLIC ACIDOSIS",
      "count": 119
    },
    {
      "term": "RENAL FAILURE ACUTE",
      "count": 118
    },
    {
      "term": "PSEUDOMONAS INFECTION",
      "count": 117
    },
    {
      "term": "DECREASED APPETITE",
      "count": 115
    },
    {
      "term": "PLATELET COUNT DECREASED",
      "count": 114
    },
    {
      "term": "DISSEMINATED INTRAVASCULAR COAGULATION",
      "count": 112
    },
    {
      "term": "DRUG-INDUCED LIVER INJURY",
      "count": 112
    },
    {
      "term": "ENTEROCOCCAL INFECTION",
      "count": 111
    },
    {
      "term": "FUSARIUM INFECTION",
      "count": 111
    },
    {
      "term": "HEPATIC ENZYME INCREASED",
      "count": 111
    },
    {
      "term": "SHOCK",
      "count": 111
    },
    {
      "term": "HEPATIC FAILURE",
      "count": 110
    },
    {
      "term": "EYE PAIN",
      "count": 108
    },
    {
      "term": "PNEUMONIA FUNGAL",
      "count": 107
    },
    {
      "term": "RESPIRATORY DISTRESS",
      "count": 107
    },
    {
      "term": "ASPARTATE AMINOTRANSFERASE INCREASED",
      "count": 106
    },
    {
      "term": "MATERNAL EXPOSURE DURING PREGNANCY",
      "count": 106
    },
    {
      "term": "BRAIN OEDEMA",
      "count": 103
    },
    {
      "term": "RESPIRATORY DISORDER",
      "count": 103
    },
    {
      "term": "DIZZINESS",
      "count": 102
    }
  ]
}