{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "OFF LABEL USE",
      "count": 345
    },
    {
      "term": "DISEASE PROGRESSION",
      "count": 294
    },
    {
      "term": "DIARRHOEA",
      "count": 289
    },
    {
      "term": "NAUSEA",
      "count": 215
    },
    {
      "term": "FATIGUE",
      "count": 189
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 152
    },
    {
      "term": "METASTASES TO CENTRAL NERVOUS SYSTEM",
      "count": 145
    },
    {
      "term": "NEUROPATHY PERIPHERAL",
      "count": 142
    },
    {
      "term": "VOMITING",
      "count": 136
    },
    {
      "term": "NEUTROPENIA",
      "count": 115
    },
    {
      "term": "ANAEMIA",
      "count": 105
    },
    {
      "term": "HEADACHE",
      "count": 104
    },
    {
      "term": "DYSPNOEA",
      "count": 95
    },
    {
      "term": "BACK PAIN",
      "count": 91
    },
    {
      "term": "PNEUMONIA",
      "count": 91
    },
    {
      "term": "PYREXIA",
      "count": 91
    },
    {
      "term": "COUGH",
      "count": 87
    },
    {
      "term": "EJECTION FRACTION DECREASED",
      "count": 84
    },
    {
      "term": "CONSTIPATION",
      "count": 83
    },
    {
      "term": "BREAST CANCER METASTATIC",
      "count": 80
    },
    {
      "term": "DRUG INEFFECTIVE",
      "count": 79
    },
    {
      "term": "URINARY TRACT INFECTION",
      "count": 78
    },
    {
      "term": "WEIGHT DECREASED",
      "count": 78
    },
    {
      "term": "SEIZURE",
      "count": 74
    },
    {
      "term": "DECREASED APPETITE",
      "count": 72
    },
    {
      "term": "DEATH",
      "count": 71
    },
    {
      "term": "METASTASES TO LUNG",
      "count": 68
    },
    {
      "term": "MUCOSAL INFLAMMATION",
      "count": 66
    },
    {
      "term": "ASTHENIA",
      "count": 64
    },
    {
      "term": "PLATELET COUNT DECREASED",
      "count": 63
    },
    {
      "term": "HYPOKALAEMIA",
      "count": 62
    },
    {
      "term": "METASTASES TO LYMPH NODES",
      "count": 59
    },
    {
      "term": "ALOPECIA",
      "count": 58
    },
    {
      "term": "PLEURAL EFFUSION",
      "count": 57
    },
    {
      "term": "CHEST PAIN",
      "count": 55
    },
    {
      "term": "METASTASES TO BONE",
      "count": 54
    },
    {
      "term": "RASH",
      "count": 53
    },
    {
      "term": "MALIGNANT NEOPLASM PROGRESSION",
      "count": 51
    },
    {
      "term": "BREAST CANCER",
      "count": 50
    },
    {
      "term": "LOWER RESPIRATORY TRACT INFECTION",
      "count": 50
    },
    {
      "term": "SEPSIS",
      "count": 50
    },
    {
      "term": "MYELOSUPPRESSION",
      "count": 48
    },
    {
      "term": "EPISTAXIS",
      "count": 47
    },
    {
      "term": "INSOMNIA",
      "count": 47
    },
    {
      "term": "PALMAR-PLANTAR ERYTHRODYSAESTHESIA SYNDROME",
      "count": 47
    },
    {
      "term": "THERAPY PARTIAL RESPONDER",
      "count": 47
    },
    {
      "term": "PNEUMONITIS",
      "count": 46
    },
    {
      "term": "C-REACTIVE PROTEIN INCREASED",
      "count": 45
    },
    {
      "term": "DIZZINESS",
      "count": 45
    },
    {
      "term": "GENERAL PHYSICAL HEALTH DETERIORATION",
      "count": 45
    },
    {
      "term": "ARTHRALGIA",
      "count": 43
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 43
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 42
    },
    {
      "term": "LACRIMATION INCREASED",
      "count": 42
    },
    {
      "term": "VASCULAR DEVICE INFECTION",
      "count": 42
    },
    {
      "term": "POLYNEUROPATHY",
      "count": 41
    },
    {
      "term": "COVID-19",
      "count": 39
    },
    {
      "term": "HEPATOTOXICITY",
      "count": 38
    },
    {
      "term": "PALPITATIONS",
      "count": 37
    },
    {
      "term": "ALANINE AMINOTRANSFERASE INCREASED",
      "count": 36
    },
    {
      "term": "ASPARTATE AMINOTRANSFERASE INCREASED",
      "count": 35
    },
    {
      "term": "NEOPLASM PROGRESSION",
      "count": 35
    },
    {
      "term": "NASOPHARYNGITIS",
      "count": 34
    },
    {
      "term": "NEUTROPHIL COUNT DECREASED",
      "count": 34
    },
    {
      "term": "OROPHARYNGEAL PAIN",
      "count": 34
    },
    {
      "term": "DRY SKIN",
      "count": 33
    },
    {
      "term": "DYSPEPSIA",
      "count": 33
    },
    {
      "term": "FEBRILE NEUTROPENIA",
      "count": 33
    },
    {
      "term": "METASTASES TO LIVER",
      "count": 33
    },
    {
      "term": "OVERDOSE",
      "count": 33
    },
    {
      "term": "SKIN FISSURES",
      "count": 33
    },
    {
      "term": "STOMATITIS",
      "count": 33
    },
    {
      "term": "BRAIN OEDEMA",
      "count": 32
    },
    {
      "term": "INTENTIONAL PRODUCT USE ISSUE",
      "count": 32
    },
    {
      "term": "PAIN IN EXTREMITY",
      "count": 32
    },
    {
      "term": "RASH PRURITIC",
      "count": 32
    },
    {
      "term": "CANDIDA INFECTION",
      "count": 31
    },
    {
      "term": "PARONYCHIA",
      "count": 31
    },
    {
      "term": "PAIN IN JAW",
      "count": 30
    },
    {
      "term": "PANCYTOPENIA",
      "count": 30
    },
    {
      "term": "WHITE BLOOD CELL COUNT DECREASED",
      "count": 30
    },
    {
      "term": "HYPONATRAEMIA",
      "count": 29
    },
    {
      "term": "PRODUCT USE ISSUE",
      "count": 29
    },
    {
      "term": "ACUTE KIDNEY INJURY",
      "count": 28
    },
    {
      "term": "PRURITUS",
      "count": 28
    },
    {
      "term": "LETHARGY",
      "count": 27
    },
    {
      "term": "ASCITES",
      "count": 26
    },
    {
      "term": "HYPOAESTHESIA",
      "count": 26
    },
    {
      "term": "OEDEMA PERIPHERAL",
      "count": 26
    },
    {
      "term": "PSEUDOMONAL SEPSIS",
      "count": 26
    },
    {
      "term": "RECTAL HAEMORRHAGE",
      "count": 26
    },
    {
      "term": "ANXIETY",
      "count": 25
    },
    {
      "term": "CARDIOTOXICITY",
      "count": 25
    },
    {
      "term": "GAMMA-GLUTAMYLTRANSFERASE INCREASED",
      "count": 25
    },
    {
      "term": "MUSCLE SPASMS",
      "count": 25
    },
    {
      "term": "PULMONARY EMBOLISM",
      "count": 25
    },
    {
      "term": "STREPTOCOCCAL SEPSIS",
      "count": 25
    },
    {
      "term": "COLITIS",
      "count": 24
    },
    {
      "term": "DEEP VEIN THROMBOSIS",
      "count": 24
    },
    {
      "term": "HYPERTRANSAMINASAEMIA",
      "count": 24
    }
  ]
}