{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-05-19",
    "results": {
      "skip": 0,
      "limit": 1,
      "total": 1
    }
  },
  "results": [
    {
      "submissions": [
        {
          "submission_type": "ORIG",
          "submission_number": "1",
          "submission_status": "AP",
          "submission_status_date": "20220225",
          "review_priority": "UNKNOWN",
          "submission_class_code": "UNKNOWN",
          "application_docs": [
            {
              "id": "70758",
              "url": "https://www.accessdata.fda.gov/drugsatfda_docs/appletter/2022/217082Orig1s000MGltr.pdf",
              "date": "20220413",
              "type": "Letter"
            }
          ]
        }
      ],
      "application_number": "NDA217082",
      "sponsor_name": "CONTINENTAL CARBONIC PRODUCTS, INC.",
      "openfda": {
        "application_number": [
          "NDA217082"
        ],
        "brand_name": [
          "CARBON DIOXIDE"
        ],
        "generic_name": [
          "CARBON DIOXIDE"
        ],
        "manufacturer_name": [
          "Matheson Tri-Gas, Inc."
        ],
        "product_ndc": [
          "55037-402"
        ],
        "product_type": [
          "HUMAN PRESCRIPTION DRUG"
        ],
        "route": [
          "RESPIRATORY (INHALATION)"
        ],
        "substance_name": [
          "CARBON DIOXIDE"
        ],
        "rxcui": [
          "347967"
        ],
        "spl_id": [
          "44ff9818-6626-3162-e063-6294a90a1681"
        ],
        "spl_set_id": [
          "10bcfbfb-2bd8-ec22-e063-6294a90afbfe"
        ],
        "package_ndc": [
          "55037-402-01",
          "55037-402-02",
          "55037-402-03",
          "55037-402-04",
          "55037-402-05",
          "55037-402-06",
          "55037-402-07",
          "55037-402-08",
          "55037-402-09",
          "55037-402-10",
          "55037-402-11",
          "55037-402-12",
          "55037-402-14",
          "55037-402-15",
          "55037-402-16",
          "55037-402-17",
          "55037-402-18",
          "55037-402-19",
          "55037-402-20",
          "55037-402-21",
          "55037-402-22",
          "55037-402-23",
          "55037-402-24",
          "55037-402-25",
          "55037-402-26",
          "55037-402-27",
          "55037-402-28",
          "55037-402-29",
          "55037-402-30",
          "55037-402-31",
          "55037-402-32"
        ],
        "nui": [
          "N0000180185",
          "N0000010258"
        ],
        "pharm_class_epc": [
          "Radiographic Contrast Agent [EPC]"
        ],
        "pharm_class_moa": [
          "X-Ray Contrast Activity [MoA]"
        ],
        "unii": [
          "142M471B3J"
        ]
      },
      "products": [
        {
          "product_number": "001",
          "reference_drug": "No",
          "brand_name": "CARBON DIOXIDE, USP",
          "active_ingredients": [
            {
              "name": "CARBON DIOXIDE",
              "strength": "N/A"
            }
          ],
          "reference_standard": "No",
          "dosage_form": "GAS",
          "route": "INHALATION",
          "marketing_status": "Prescription"
        }
      ]
    }
  ]
}