{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-07-27",
    "results": {
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  "results": [
    {
      "pma_number": "P140029",
      "supplement_number": "S027",
      "applicant": "Q-Med AB",
      "street_1": "Seminariegatan 21",
      "street_2": "",
      "city": "Uppsala",
      "state": "",
      "zip": "S-752 28",
      "zip_ext": "",
      "generic_name": "Implant, dermal, for aesthetic use",
      "trade_name": "Restylane Defyne",
      "product_code": "LMH",
      "advisory_committee": "SU",
      "advisory_committee_description": "General, Plastic Surgery",
      "supplement_type": "Panel Track",
      "supplement_reason": "Labeling Change - Indications/instructions/shelf life/tradename",
      "expedited_review_flag": "N",
      "date_received": "2020-06-16",
      "decision_date": "2021-01-29",
      "docket_number": "21M-0153",
      "fed_reg_notice_date": "2021-02-05",
      "decision_code": "APPR",
      "ao_statement": "Approval for Restylane Defyne.  The device is indicated for injection into the mid-to deep dermis (subcutaneous and/or supraperiosteal) for augmentation of the chin region to improve the chin profile in patients with mild to moderate chin retrusion over the age of 21.",
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        "medical_specialty_description": "Unknown",
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