{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-07-02"
  },
  "results": [
    {
      "term": "Vomiting",
      "count": 112
    },
    {
      "term": "Death by euthanasia",
      "count": 110
    },
    {
      "term": "Weight loss",
      "count": 94
    },
    {
      "term": "Diarrhoea",
      "count": 69
    },
    {
      "term": "Lack of efficacy - NOS",
      "count": 68
    },
    {
      "term": "Elevated alanine aminotransferase (ALT)",
      "count": 65
    },
    {
      "term": "Decreased appetite",
      "count": 61
    },
    {
      "term": "Thrombocytopenia",
      "count": 56
    },
    {
      "term": "Anorexia",
      "count": 50
    },
    {
      "term": "Death",
      "count": 46
    },
    {
      "term": "Elevated serum alkaline phosphatase (SAP)",
      "count": 44
    },
    {
      "term": "Lethargy (see also Central nervous system depression in 'Neurological')",
      "count": 40
    },
    {
      "term": "Elevated serum alkaline phosphatase (ALP)",
      "count": 33
    },
    {
      "term": "Polyuria",
      "count": 33
    },
    {
      "term": "Neutrophilia",
      "count": 31
    },
    {
      "term": "Elevated gamma-glutamyl transferase (GGT)",
      "count": 30
    },
    {
      "term": "Not eating",
      "count": 30
    },
    {
      "term": "Polydipsia",
      "count": 30
    },
    {
      "term": "Leucocytosis NOS",
      "count": 29
    },
    {
      "term": "Anaemia NOS",
      "count": 26
    },
    {
      "term": "Decreased haematocrit",
      "count": 26
    },
    {
      "term": "Lethargy (see also Central nervous system depression in Neurological)",
      "count": 25
    },
    {
      "term": "Nausea",
      "count": 25
    },
    {
      "term": "Lymphopenia",
      "count": 24
    },
    {
      "term": "Elevated blood urea nitrogen (BUN)",
      "count": 20
    },
    {
      "term": "Monocytosis",
      "count": 19
    },
    {
      "term": "Seizure NOS",
      "count": 19
    },
    {
      "term": "Malaise",
      "count": 18
    },
    {
      "term": "Inappetence",
      "count": 17
    },
    {
      "term": "Panting",
      "count": 17
    },
    {
      "term": "Decreased red blood cell count",
      "count": 15
    },
    {
      "term": "Elevated symmetrical dimethylarginine (SDMA)",
      "count": 15
    },
    {
      "term": "Eosinopenia",
      "count": 14
    },
    {
      "term": "Hypoalbuminaemia",
      "count": 13
    },
    {
      "term": "Lack of efficacy (neoplasia, relapse)",
      "count": 13
    },
    {
      "term": "Neutropenia",
      "count": 13
    },
    {
      "term": "Weakness",
      "count": 13
    },
    {
      "term": "Decreased haemoglobin",
      "count": 12
    },
    {
      "term": "Elevated total bilirubin",
      "count": 12
    },
    {
      "term": "Fever",
      "count": 12
    },
    {
      "term": "Leucopenia NOS",
      "count": 12
    },
    {
      "term": "Loose stool",
      "count": 12
    },
    {
      "term": "Inappropriate urination",
      "count": 11
    },
    {
      "term": "Low platelet count",
      "count": 11
    },
    {
      "term": "Overdose",
      "count": 11
    },
    {
      "term": "Unwell",
      "count": 11
    },
    {
      "term": "Appetite loss",
      "count": 10
    },
    {
      "term": "Hypoproteinaemia",
      "count": 10
    },
    {
      "term": "Lack of efficacy (neoplasia, no remission)",
      "count": 10
    },
    {
      "term": "Decreased packed cell volume (PCV)",
      "count": 9
    },
    {
      "term": "Lymphocytosis",
      "count": 9
    },
    {
      "term": "Behavioural disorder NOS",
      "count": 8
    },
    {
      "term": "Drooling",
      "count": 8
    },
    {
      "term": "Elevated aspartate aminotransferase (AST)",
      "count": 8
    },
    {
      "term": "Elevated creatinine",
      "count": 8
    },
    {
      "term": "Hyperphosphataemia",
      "count": 8
    },
    {
      "term": "Hypochloraemia",
      "count": 8
    },
    {
      "term": "Laboured breathing",
      "count": 8
    },
    {
      "term": "Medication error NOS",
      "count": 8
    },
    {
      "term": "Proteinuria",
      "count": 8
    },
    {
      "term": "Systemic disorder NOS",
      "count": 8
    },
    {
      "term": "Bloody diarrhoea",
      "count": 7
    },
    {
      "term": "Bruising",
      "count": 7
    },
    {
      "term": "General illness",
      "count": 7
    },
    {
      "term": "Icterus",
      "count": 7
    },
    {
      "term": "Abnormal radiograph finding",
      "count": 6
    },
    {
      "term": "Abnormal ultrasound finding",
      "count": 6
    },
    {
      "term": "Emesis (multiple)",
      "count": 6
    },
    {
      "term": "Enlarged lymph node (localised)",
      "count": 6
    },
    {
      "term": "Enlarged lymph nodes (generalised)",
      "count": 6
    },
    {
      "term": "Generalised weakness",
      "count": 6
    },
    {
      "term": "Increased percentage reticulocytes",
      "count": 6
    },
    {
      "term": "Large platelets",
      "count": 6
    },
    {
      "term": "Not himself/herself",
      "count": 6
    },
    {
      "term": "Reduced globulins",
      "count": 6
    },
    {
      "term": "Restlessness",
      "count": 6
    },
    {
      "term": "Skin lesion NOS",
      "count": 6
    },
    {
      "term": "Tiredness",
      "count": 6
    },
    {
      "term": "Unable to rise",
      "count": 6
    },
    {
      "term": "Uncomfortable",
      "count": 6
    },
    {
      "term": "Ataxia",
      "count": 5
    },
    {
      "term": "Blindness",
      "count": 5
    },
    {
      "term": "Cough",
      "count": 5
    },
    {
      "term": "Decreased urine concentration",
      "count": 5
    },
    {
      "term": "Elevated liver enzymes",
      "count": 5
    },
    {
      "term": "Epistaxis",
      "count": 5
    },
    {
      "term": "High pancreatic-specific lipase",
      "count": 5
    },
    {
      "term": "Hyperglycaemia",
      "count": 5
    },
    {
      "term": "Hypocalcaemia",
      "count": 5
    },
    {
      "term": "Increased band neutrophilia",
      "count": 5
    },
    {
      "term": "Jaundice",
      "count": 5
    },
    {
      "term": "Other abnormal test result NOS",
      "count": 5
    },
    {
      "term": "Shaking",
      "count": 5
    },
    {
      "term": "Urinary tract infection",
      "count": 5
    },
    {
      "term": "Weight gain",
      "count": 5
    },
    {
      "term": "Abnormal cytology",
      "count": 4
    },
    {
      "term": "Azotaemia",
      "count": 4
    },
    {
      "term": "Decreased activity",
      "count": 4
    },
    {
      "term": "Disorientation",
      "count": 4
    },
    {
      "term": "Ecchymosis",
      "count": 4
    }
  ]
}