{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-07-02"
  },
  "results": [
    {
      "term": "Lack of efficacy - NOS",
      "count": 850
    },
    {
      "term": "Injection site swelling",
      "count": 688
    },
    {
      "term": "Wound",
      "count": 399
    },
    {
      "term": "Injection site pain",
      "count": 298
    },
    {
      "term": "Pain NOS",
      "count": 290
    },
    {
      "term": "Swelling NOS",
      "count": 285
    },
    {
      "term": "Injection site necrosis",
      "count": 233
    },
    {
      "term": "Swollen limb",
      "count": 223
    },
    {
      "term": "Injection site complication NOS",
      "count": 212
    },
    {
      "term": "Injection site bruising",
      "count": 206
    },
    {
      "term": "Injection site bleeding",
      "count": 193
    },
    {
      "term": "Licking at injection site",
      "count": 183
    },
    {
      "term": "Limb non-weight bearing",
      "count": 173
    },
    {
      "term": "Diarrhoea",
      "count": 167
    },
    {
      "term": "Lameness",
      "count": 152
    },
    {
      "term": "Injection site serosanguinous discharge",
      "count": 145
    },
    {
      "term": "Vomiting",
      "count": 145
    },
    {
      "term": "Malodour",
      "count": 136
    },
    {
      "term": "Injection site erythema",
      "count": 134
    },
    {
      "term": "Skin slough",
      "count": 133
    },
    {
      "term": "Injection site skin discolouration",
      "count": 131
    },
    {
      "term": "Panting",
      "count": 131
    },
    {
      "term": "Lethargy (see also Central nervous system depression in Neurological)",
      "count": 130
    },
    {
      "term": "Anorexia",
      "count": 124
    },
    {
      "term": "Decreased appetite",
      "count": 117
    },
    {
      "term": "Not eating",
      "count": 117
    },
    {
      "term": "Limping",
      "count": 115
    },
    {
      "term": "Lethargy (see also Central nervous system depression in 'Neurological')",
      "count": 111
    },
    {
      "term": "Injection site inflammation",
      "count": 109
    },
    {
      "term": "Lack of efficacy (neoplasia, no remission)",
      "count": 106
    },
    {
      "term": "Bruising",
      "count": 103
    },
    {
      "term": "Injection site mucopurulent discharge",
      "count": 101
    },
    {
      "term": "Reluctant to move",
      "count": 90
    },
    {
      "term": "Injection site reddening",
      "count": 89
    },
    {
      "term": "Injection site oedema",
      "count": 88
    },
    {
      "term": "Local swelling (not application site)",
      "count": 83
    },
    {
      "term": "Injection site scab",
      "count": 82
    },
    {
      "term": "Death by euthanasia",
      "count": 78
    },
    {
      "term": "Injection site weeping (see also Skin)",
      "count": 73
    },
    {
      "term": "Weight loss",
      "count": 73
    },
    {
      "term": "Lack of efficacy (neoplasia, partial remission)",
      "count": 71
    },
    {
      "term": "Injection site reaction NOS",
      "count": 70
    },
    {
      "term": "Injection site ulcer",
      "count": 70
    },
    {
      "term": "Uncomfortable",
      "count": 61
    },
    {
      "term": "Injection site infection",
      "count": 60
    },
    {
      "term": "Fever",
      "count": 59
    },
    {
      "term": "Injection site serous discharge",
      "count": 59
    },
    {
      "term": "Overdose",
      "count": 59
    },
    {
      "term": "Death",
      "count": 58
    },
    {
      "term": "Discomfort NOS",
      "count": 58
    },
    {
      "term": "Bloody diarrhoea",
      "count": 57
    },
    {
      "term": "Vocalisation",
      "count": 57
    },
    {
      "term": "Skin necrosis",
      "count": 52
    },
    {
      "term": "Injection site discharge NOS",
      "count": 46
    },
    {
      "term": "Elevated serum alkaline phosphatase (ALP)",
      "count": 44
    },
    {
      "term": "Elevated alanine aminotransferase (ALT)",
      "count": 43
    },
    {
      "term": "Lack of efficacy (neoplasia, relapse)",
      "count": 42
    },
    {
      "term": "Mast cell tumour",
      "count": 42
    },
    {
      "term": "Inappetence",
      "count": 41
    },
    {
      "term": "Mass NOS",
      "count": 41
    },
    {
      "term": "Monocytosis",
      "count": 40
    },
    {
      "term": "Polydipsia",
      "count": 40
    },
    {
      "term": "Local skin slough",
      "count": 39
    },
    {
      "term": "Cellulitis",
      "count": 38
    },
    {
      "term": "Injection site lesion",
      "count": 36
    },
    {
      "term": "Necrotic wound",
      "count": 36
    },
    {
      "term": "Neutrophilia",
      "count": 36
    },
    {
      "term": "Erythema (for urticaria see Immune SOC)",
      "count": 35
    },
    {
      "term": "Not drinking",
      "count": 35
    },
    {
      "term": "Whining",
      "count": 35
    },
    {
      "term": "Dehydration",
      "count": 34
    },
    {
      "term": "Leucocytosis NOS",
      "count": 34
    },
    {
      "term": "Pitting oedema",
      "count": 34
    },
    {
      "term": "Reddening of the skin",
      "count": 34
    },
    {
      "term": "Enlarged lymph node (localised)",
      "count": 33
    },
    {
      "term": "Tachycardia",
      "count": 33
    },
    {
      "term": "Drug administered at inappropriate site",
      "count": 32
    },
    {
      "term": "Injection site weeping (see also 'skin')",
      "count": 32
    },
    {
      "term": "Polyuria",
      "count": 31
    },
    {
      "term": "Elevated temperature",
      "count": 30
    },
    {
      "term": "Localised oedema (not application site)",
      "count": 30
    },
    {
      "term": "Shaking",
      "count": 30
    },
    {
      "term": "Loose stool",
      "count": 28
    },
    {
      "term": "Underdose",
      "count": 28
    },
    {
      "term": "Hypochloraemia",
      "count": 27
    },
    {
      "term": "Injection site thickening",
      "count": 27
    },
    {
      "term": "Restlessness",
      "count": 27
    },
    {
      "term": "Hyperglycaemia",
      "count": 26
    },
    {
      "term": "Scar",
      "count": 25
    },
    {
      "term": "Anxiety",
      "count": 23
    },
    {
      "term": "Weakness",
      "count": 23
    },
    {
      "term": "Constipation",
      "count": 22
    },
    {
      "term": "Delayed healing",
      "count": 22
    },
    {
      "term": "Elevated serum alkaline phosphatase (SAP)",
      "count": 22
    },
    {
      "term": "Injection site abscess",
      "count": 22
    },
    {
      "term": "Behavioural disorder NOS",
      "count": 21
    },
    {
      "term": "Drinking a lot",
      "count": 21
    },
    {
      "term": "Elevated blood urea nitrogen (BUN)",
      "count": 21
    },
    {
      "term": "Injection site skin change NOS",
      "count": 21
    },
    {
      "term": "Laboured breathing",
      "count": 21
    }
  ]
}