{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-07-02"
  },
  "results": [
    {
      "term": "Emesis",
      "count": 55388
    },
    {
      "term": "Vomiting",
      "count": 47694
    },
    {
      "term": "Lethargy (see also Central nervous system depression in 'Neurological')",
      "count": 22310
    },
    {
      "term": "Lack of efficacy (ectoparasite) - flea",
      "count": 19463
    },
    {
      "term": "Lack of efficacy - NOS",
      "count": 12911
    },
    {
      "term": "Diarrhoea",
      "count": 8672
    },
    {
      "term": "INEFFECTIVE, HEARTWORM LARVAE",
      "count": 5668
    },
    {
      "term": "Seizure NOS",
      "count": 5335
    },
    {
      "term": "Lack of efficacy (endoparasite) - heartworm",
      "count": 5092
    },
    {
      "term": "Behavioural disorder NOS",
      "count": 4713
    },
    {
      "term": "Anorexia",
      "count": 4480
    },
    {
      "term": "Depression",
      "count": 4276
    },
    {
      "term": "Pruritus",
      "count": 3883
    },
    {
      "term": "Ataxia",
      "count": 3857
    },
    {
      "term": "UNPALATABLE",
      "count": 3701
    },
    {
      "term": "Shaking",
      "count": 3492
    },
    {
      "term": "Itching",
      "count": 3171
    },
    {
      "term": "Emesis (multiple)",
      "count": 3132
    },
    {
      "term": "Other abnormal test result NOS",
      "count": 3073
    },
    {
      "term": "Not eating",
      "count": 3016
    },
    {
      "term": "Lack of efficacy (endoparasite) - hookworm",
      "count": 2986
    },
    {
      "term": "Weight gain",
      "count": 2881
    },
    {
      "term": "Trembling",
      "count": 2858
    },
    {
      "term": "Death",
      "count": 2780
    },
    {
      "term": "Overdose",
      "count": 2749
    },
    {
      "term": "Accidental exposure",
      "count": 2695
    },
    {
      "term": "Decreased appetite",
      "count": 2548
    },
    {
      "term": "Weight loss",
      "count": 2481
    },
    {
      "term": "Lack of efficacy (flea)",
      "count": 2268
    },
    {
      "term": "Death by euthanasia",
      "count": 1773
    },
    {
      "term": "Elevated alanine aminotransferase (ALT)",
      "count": 1670
    },
    {
      "term": "Drug dose omission",
      "count": 1666
    },
    {
      "term": "Vocalisation",
      "count": 1555
    },
    {
      "term": "Panting",
      "count": 1411
    },
    {
      "term": "Abnormal posture NOS",
      "count": 1366
    },
    {
      "term": "INEFFECTIVE, ASCARIDS NOS",
      "count": 1357
    },
    {
      "term": "Scratching",
      "count": 1344
    },
    {
      "term": "Tremor",
      "count": 1308
    },
    {
      "term": "Hypersalivation",
      "count": 1274
    },
    {
      "term": "Not drinking",
      "count": 1196
    },
    {
      "term": "Disorientation",
      "count": 1186
    },
    {
      "term": "Drooling",
      "count": 1156
    },
    {
      "term": "Elevated serum alkaline phosphatase (SAP)",
      "count": 1140
    },
    {
      "term": "Cough",
      "count": 1134
    },
    {
      "term": "Underdose",
      "count": 1110
    },
    {
      "term": "Loose stool",
      "count": 1106
    },
    {
      "term": "Bloody diarrhoea",
      "count": 1096
    },
    {
      "term": "Nausea",
      "count": 1095
    },
    {
      "term": "Inappetence",
      "count": 1073
    },
    {
      "term": "Fever",
      "count": 1065
    },
    {
      "term": "Convulsion",
      "count": 1061
    },
    {
      "term": "Twitching",
      "count": 999
    },
    {
      "term": "Restlessness",
      "count": 967
    },
    {
      "term": "Reddening of the skin",
      "count": 945
    },
    {
      "term": "Malaise",
      "count": 930
    },
    {
      "term": "Elevated liver enzymes",
      "count": 904
    },
    {
      "term": "Dehydration",
      "count": 894
    },
    {
      "term": "INEFFECTIVE, HOOKS",
      "count": 889
    },
    {
      "term": "Abnormal radiograph finding",
      "count": 828
    },
    {
      "term": "Lack of efficacy (endoparasite) - whipworm",
      "count": 828
    },
    {
      "term": "Pain NOS",
      "count": 767
    },
    {
      "term": "Anxiety",
      "count": 754
    },
    {
      "term": "Eye disorder NOS (for photophobia see 'neurological')",
      "count": 749
    },
    {
      "term": "Weakness",
      "count": 738
    },
    {
      "term": "Walking difficulty",
      "count": 719
    },
    {
      "term": "Adipsia",
      "count": 701
    },
    {
      "term": "Skin disorders NOS",
      "count": 685
    },
    {
      "term": "Leucocytosis NOS",
      "count": 674
    },
    {
      "term": "Polydipsia",
      "count": 660
    },
    {
      "term": "Elevated blood urea nitrogen (BUN)",
      "count": 652
    },
    {
      "term": "Hives (see also 'Skin')",
      "count": 644
    },
    {
      "term": "Inappropriate urination",
      "count": 628
    },
    {
      "term": "Anaemia NOS",
      "count": 625
    },
    {
      "term": "Digestive tract disorder NOS",
      "count": 617
    },
    {
      "term": "Appetite loss",
      "count": 611
    },
    {
      "term": "Neutrophilia",
      "count": 603
    },
    {
      "term": "Star-gazing",
      "count": 590
    },
    {
      "term": "Ear infection NOS",
      "count": 589
    },
    {
      "term": "Reluctant to move",
      "count": 579
    },
    {
      "term": "Hair loss NOS",
      "count": 548
    },
    {
      "term": "Labelled drug-drug interaction medication error",
      "count": 546
    },
    {
      "term": "Abnormal breathing",
      "count": 545
    },
    {
      "term": "Rash",
      "count": 543
    },
    {
      "term": "Allergy NOS",
      "count": 537
    },
    {
      "term": "Hyperactivity",
      "count": 532
    },
    {
      "term": "Hyperglycaemia",
      "count": 525
    },
    {
      "term": "Unable to stand",
      "count": 525
    },
    {
      "term": "Systemic disorder NOS",
      "count": 514
    },
    {
      "term": "Skin lesion NOS",
      "count": 512
    },
    {
      "term": "Pale mucous membrane",
      "count": 496
    },
    {
      "term": "Falling",
      "count": 493
    },
    {
      "term": "Elevated temperature",
      "count": 491
    },
    {
      "term": "Retching",
      "count": 486
    },
    {
      "term": "Decreased activity",
      "count": 482
    },
    {
      "term": "Neurological signs NOS",
      "count": 477
    },
    {
      "term": "Pica NOS",
      "count": 475
    },
    {
      "term": "Glazed eye",
      "count": 473
    },
    {
      "term": "Aggression",
      "count": 470
    },
    {
      "term": "Abdominal pain",
      "count": 462
    },
    {
      "term": "Confusion",
      "count": 462
    }
  ]
}