{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-07-02"
  },
  "results": [
    {
      "term": "Emesis",
      "count": 4573
    },
    {
      "term": "Vomiting",
      "count": 3715
    },
    {
      "term": "Lack of efficacy (ectoparasite) - flea",
      "count": 1593
    },
    {
      "term": "Lethargy (see also Central nervous system depression in 'Neurological')",
      "count": 1074
    },
    {
      "term": "Lack of efficacy - NOS",
      "count": 1038
    },
    {
      "term": "UNPALATABLE",
      "count": 517
    },
    {
      "term": "Behavioural disorder NOS",
      "count": 356
    },
    {
      "term": "Accidental exposure",
      "count": 324
    },
    {
      "term": "Emesis (multiple)",
      "count": 283
    },
    {
      "term": "Diarrhoea",
      "count": 278
    },
    {
      "term": "Lack of efficacy (flea)",
      "count": 247
    },
    {
      "term": "Death",
      "count": 225
    },
    {
      "term": "Anorexia",
      "count": 209
    },
    {
      "term": "Not eating",
      "count": 201
    },
    {
      "term": "Ataxia",
      "count": 183
    },
    {
      "term": "Decreased appetite",
      "count": 175
    },
    {
      "term": "Weight loss",
      "count": 169
    },
    {
      "term": "Underdose",
      "count": 159
    },
    {
      "term": "Panting",
      "count": 145
    },
    {
      "term": "Vocalisation",
      "count": 137
    },
    {
      "term": "Itching",
      "count": 130
    },
    {
      "term": "Hyperactivity",
      "count": 129
    },
    {
      "term": "Overdose",
      "count": 126
    },
    {
      "term": "Pruritus",
      "count": 117
    },
    {
      "term": "Other abnormal test result NOS",
      "count": 109
    },
    {
      "term": "Scratching",
      "count": 99
    },
    {
      "term": "Drooling",
      "count": 91
    },
    {
      "term": "Seizure NOS",
      "count": 89
    },
    {
      "term": "Dehydration",
      "count": 83
    },
    {
      "term": "Hiding",
      "count": 83
    },
    {
      "term": "Agitation",
      "count": 82
    },
    {
      "term": "Not drinking",
      "count": 80
    },
    {
      "term": "Depression",
      "count": 77
    },
    {
      "term": "Hypersalivation",
      "count": 75
    },
    {
      "term": "Drug dose omission",
      "count": 74
    },
    {
      "term": "Twitching",
      "count": 74
    },
    {
      "term": "Death by euthanasia",
      "count": 72
    },
    {
      "term": "Inappetence",
      "count": 70
    },
    {
      "term": "Fever",
      "count": 69
    },
    {
      "term": "NT - Abnormal necropsy finding NOS",
      "count": 57
    },
    {
      "term": "Hyperglycaemia",
      "count": 53
    },
    {
      "term": "Malaise",
      "count": 53
    },
    {
      "term": "Weight gain",
      "count": 52
    },
    {
      "term": "Dilated pupils",
      "count": 51
    },
    {
      "term": "Elevated alanine aminotransferase (ALT)",
      "count": 45
    },
    {
      "term": "Excessive licking and/or grooming",
      "count": 43
    },
    {
      "term": "Adipsia",
      "count": 41
    },
    {
      "term": "Elevated blood urea nitrogen (BUN)",
      "count": 41
    },
    {
      "term": "Foaming at the mouth",
      "count": 41
    },
    {
      "term": "Nausea",
      "count": 41
    },
    {
      "term": "Sneezing",
      "count": 41
    },
    {
      "term": "Open mouth breathing",
      "count": 40
    },
    {
      "term": "Disorientation",
      "count": 39
    },
    {
      "term": "Licking",
      "count": 39
    },
    {
      "term": "Neutrophilia",
      "count": 38
    },
    {
      "term": "Restlessness",
      "count": 38
    },
    {
      "term": "Aggression",
      "count": 36
    },
    {
      "term": "Elevated liver enzymes",
      "count": 35
    },
    {
      "term": "Incorrect dose administered NOS",
      "count": 35
    },
    {
      "term": "Systemic disorder NOS",
      "count": 35
    },
    {
      "term": "Drug administration error",
      "count": 34
    },
    {
      "term": "Shaking",
      "count": 34
    },
    {
      "term": "Elevated temperature",
      "count": 33
    },
    {
      "term": "Uncoded sign",
      "count": 33
    },
    {
      "term": "Anaemia NOS",
      "count": 32
    },
    {
      "term": "Cough",
      "count": 32
    },
    {
      "term": "Digestive tract disorder NOS",
      "count": 32
    },
    {
      "term": "Sleepiness - neurological disorder",
      "count": 32
    },
    {
      "term": "Abnormal breathing",
      "count": 31
    },
    {
      "term": "Leucocytosis NOS",
      "count": 31
    },
    {
      "term": "Sudden death",
      "count": 31
    },
    {
      "term": "Difficulty of Use",
      "count": 30
    },
    {
      "term": "Hypothermia",
      "count": 30
    },
    {
      "term": "No sign",
      "count": 30
    },
    {
      "term": "Renal disorder NOS",
      "count": 30
    },
    {
      "term": "Abnormal radiograph finding",
      "count": 28
    },
    {
      "term": "Elevated creatinine",
      "count": 28
    },
    {
      "term": "Anxiety",
      "count": 27
    },
    {
      "term": "Appetite loss",
      "count": 27
    },
    {
      "term": "Falling",
      "count": 27
    },
    {
      "term": "Walking difficulty",
      "count": 27
    },
    {
      "term": "Hair loss NOS",
      "count": 26
    },
    {
      "term": "Loose stool",
      "count": 26
    },
    {
      "term": "Odor, Abnormal",
      "count": 26
    },
    {
      "term": "Pale mucous membrane",
      "count": 26
    },
    {
      "term": "Tachypnoea",
      "count": 26
    },
    {
      "term": "Weakness",
      "count": 26
    },
    {
      "term": "Elevated total bilirubin",
      "count": 25
    },
    {
      "term": "Increased heart rate",
      "count": 25
    },
    {
      "term": "Retching",
      "count": 25
    },
    {
      "term": "Gagging",
      "count": 24
    },
    {
      "term": "Hind limb ataxia",
      "count": 24
    },
    {
      "term": "Lateral recumbency",
      "count": 24
    },
    {
      "term": "Reluctant to move",
      "count": 24
    },
    {
      "term": "Tablets, Abnormal",
      "count": 24
    },
    {
      "term": "Breathing difficulty",
      "count": 23
    },
    {
      "term": "Constipation",
      "count": 23
    },
    {
      "term": "Hyperthyroidism",
      "count": 23
    },
    {
      "term": "Proteinuria",
      "count": 23
    },
    {
      "term": "Blood in vomit",
      "count": 22
    }
  ]
}