{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-07-02"
  },
  "results": [
    {
      "term": "INEFFECTIVE, HEARTWORM LARVAE",
      "count": 7937
    },
    {
      "term": "Lack of efficacy (ectoparasite) - flea",
      "count": 3274
    },
    {
      "term": "Vomiting",
      "count": 2901
    },
    {
      "term": "Depression",
      "count": 1876
    },
    {
      "term": "Diarrhoea",
      "count": 1730
    },
    {
      "term": "Lack of efficacy (endoparasite) - hookworm",
      "count": 1628
    },
    {
      "term": "Anorexia",
      "count": 1487
    },
    {
      "term": "Pruritus",
      "count": 1428
    },
    {
      "term": "Lack of efficacy (ectoparasite) - tick NOS",
      "count": 1135
    },
    {
      "term": "Lethargy (see also Central nervous system depression in 'Neurological')",
      "count": 959
    },
    {
      "term": "Lack of efficacy - NOS",
      "count": 868
    },
    {
      "term": "Lack of efficacy (endoparasite) - heartworm",
      "count": 774
    },
    {
      "term": "Convulsion",
      "count": 716
    },
    {
      "term": "Ataxia",
      "count": 599
    },
    {
      "term": "INEFFECTIVE, ASCARIDS NOS",
      "count": 566
    },
    {
      "term": "Lack of efficacy (endoparasite) - whipworm",
      "count": 549
    },
    {
      "term": "Trembling",
      "count": 548
    },
    {
      "term": "Behavioural disorder NOS",
      "count": 545
    },
    {
      "term": "Seizure NOS",
      "count": 539
    },
    {
      "term": "Application site alopecia",
      "count": 507
    },
    {
      "term": "Lack of efficacy (ectoparasite) - ear mite",
      "count": 504
    },
    {
      "term": "Death",
      "count": 502
    },
    {
      "term": "Hypersalivation",
      "count": 406
    },
    {
      "term": "Alopecia NOS",
      "count": 357
    },
    {
      "term": "Lack of efficacy (ectoparasite) - Sarcoptes",
      "count": 338
    },
    {
      "term": "Hyperactivity",
      "count": 327
    },
    {
      "term": "Accidental exposure",
      "count": 317
    },
    {
      "term": "No sign",
      "count": 316
    },
    {
      "term": "Fever",
      "count": 314
    },
    {
      "term": "Bloody diarrhoea",
      "count": 303
    },
    {
      "term": "Urticaria",
      "count": 302
    },
    {
      "term": "Shaking",
      "count": 283
    },
    {
      "term": "Application site lesion",
      "count": 280
    },
    {
      "term": "Elevated alanine aminotransferase (ALT)",
      "count": 270
    },
    {
      "term": "Death by euthanasia",
      "count": 267
    },
    {
      "term": "Dermatitis",
      "count": 254
    },
    {
      "term": "Elevated serum alkaline phosphatase (SAP)",
      "count": 234
    },
    {
      "term": "Restlessness",
      "count": 231
    },
    {
      "term": "Weight loss",
      "count": 230
    },
    {
      "term": "Application site erythema",
      "count": 225
    },
    {
      "term": "Cough",
      "count": 224
    },
    {
      "term": "Application site pruritus",
      "count": 220
    },
    {
      "term": "Vocalisation",
      "count": 219
    },
    {
      "term": "Skin hyperaemia",
      "count": 216
    },
    {
      "term": "Application site hair change",
      "count": 215
    },
    {
      "term": "Anaemia NOS",
      "count": 211
    },
    {
      "term": "Skin lesion NOS",
      "count": 211
    },
    {
      "term": "INEFFECTIVE, HOOKS",
      "count": 197
    },
    {
      "term": "Drug dose administration interval too short",
      "count": 191
    },
    {
      "term": "Polypnoea",
      "count": 184
    },
    {
      "term": "Underdose",
      "count": 179
    },
    {
      "term": "Application site inflammation",
      "count": 178
    },
    {
      "term": "Lack of efficacy (ectoparasite) - mite NOS",
      "count": 173
    },
    {
      "term": "Leucocytosis NOS",
      "count": 172
    },
    {
      "term": "Weakness",
      "count": 167
    },
    {
      "term": "Overdose",
      "count": 160
    },
    {
      "term": "Pain NOS",
      "count": 159
    },
    {
      "term": "Rash",
      "count": 159
    },
    {
      "term": "Loose stool",
      "count": 156
    },
    {
      "term": "Polydipsia",
      "count": 154
    },
    {
      "term": "Other abnormal test result NOS",
      "count": 153
    },
    {
      "term": "Elevated blood urea nitrogen (BUN)",
      "count": 149
    },
    {
      "term": "Abnormal radiograph finding",
      "count": 148
    },
    {
      "term": "Decreased appetite",
      "count": 148
    },
    {
      "term": "Lack of efficacy (endoparasite) - tapeworm",
      "count": 139
    },
    {
      "term": "Dyspnoea",
      "count": 138
    },
    {
      "term": "Anaphylaxis",
      "count": 137
    },
    {
      "term": "Facial oedema",
      "count": 137
    },
    {
      "term": "Emesis",
      "count": 135
    },
    {
      "term": "Not eating",
      "count": 133
    },
    {
      "term": "Thrombocytopenia",
      "count": 133
    },
    {
      "term": "Panting",
      "count": 132
    },
    {
      "term": "Skin scab",
      "count": 132
    },
    {
      "term": "Tachypnoea",
      "count": 132
    },
    {
      "term": "Elevated liver enzymes",
      "count": 119
    },
    {
      "term": "Application site reaction NOS",
      "count": 117
    },
    {
      "term": "Application site pain",
      "count": 112
    },
    {
      "term": "Itching",
      "count": 112
    },
    {
      "term": "Moist dermatitis",
      "count": 112
    },
    {
      "term": "Pacing",
      "count": 112
    },
    {
      "term": "Lethargy (see also Central nervous system depression in Neurological)",
      "count": 110
    },
    {
      "term": "Confusion",
      "count": 105
    },
    {
      "term": "Twitching",
      "count": 105
    },
    {
      "term": "Dehydration",
      "count": 103
    },
    {
      "term": "Pyoderma",
      "count": 101
    },
    {
      "term": "Tremor",
      "count": 101
    },
    {
      "term": "Application site hair loss",
      "count": 97
    },
    {
      "term": "Pale mucous membrane",
      "count": 97
    },
    {
      "term": "Drug administration error",
      "count": 95
    },
    {
      "term": "Elevated creatinine",
      "count": 94
    },
    {
      "term": "Elevated total bilirubin",
      "count": 93
    },
    {
      "term": "Polyuria",
      "count": 93
    },
    {
      "term": "Hiding",
      "count": 92
    },
    {
      "term": "Disorientation",
      "count": 91
    },
    {
      "term": "Hypoglycaemia",
      "count": 91
    },
    {
      "term": "Apprehension",
      "count": 88
    },
    {
      "term": "Inappetence",
      "count": 87
    },
    {
      "term": "Drug dose omission",
      "count": 86
    },
    {
      "term": "Reluctant to move",
      "count": 86
    },
    {
      "term": "Tachycardia",
      "count": 86
    }
  ]
}