{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-07-02"
  },
  "results": [
    {
      "term": "Application site alopecia",
      "count": 5933
    },
    {
      "term": "Application site hair loss",
      "count": 4433
    },
    {
      "term": "Lack of efficacy (ectoparasite) - flea",
      "count": 2896
    },
    {
      "term": "Vomiting",
      "count": 2777
    },
    {
      "term": "Anorexia",
      "count": 2173
    },
    {
      "term": "Lethargy (see also Central nervous system depression in 'Neurological')",
      "count": 1954
    },
    {
      "term": "Depression",
      "count": 1687
    },
    {
      "term": "Application site scab",
      "count": 1440
    },
    {
      "term": "Application site lesion",
      "count": 1364
    },
    {
      "term": "Application site erythema",
      "count": 1243
    },
    {
      "term": "Diarrhoea",
      "count": 1192
    },
    {
      "term": "Application site inflammation",
      "count": 999
    },
    {
      "term": "Ataxia",
      "count": 980
    },
    {
      "term": "Behavioural disorder NOS",
      "count": 964
    },
    {
      "term": "Death",
      "count": 947
    },
    {
      "term": "Fever",
      "count": 925
    },
    {
      "term": "Application site reddening",
      "count": 924
    },
    {
      "term": "Application site pruritus",
      "count": 911
    },
    {
      "term": "Lack of efficacy (ectoparasite) - ear mite",
      "count": 909
    },
    {
      "term": "Pruritus",
      "count": 876
    },
    {
      "term": "Application site irritation",
      "count": 850
    },
    {
      "term": "Weight loss",
      "count": 681
    },
    {
      "term": "Hypersalivation",
      "count": 571
    },
    {
      "term": "Hiding",
      "count": 551
    },
    {
      "term": "INEFFECTIVE, ASCARIDS NOS",
      "count": 542
    },
    {
      "term": "Skin scab",
      "count": 532
    },
    {
      "term": "Vocalisation",
      "count": 511
    },
    {
      "term": "Not eating",
      "count": 506
    },
    {
      "term": "Seizure NOS",
      "count": 488
    },
    {
      "term": "Application site burn",
      "count": 482
    },
    {
      "term": "Lack of efficacy (endoparasite) - tapeworm",
      "count": 480
    },
    {
      "term": "Decreased appetite",
      "count": 464
    },
    {
      "term": "Alopecia NOS",
      "count": 463
    },
    {
      "term": "Death by euthanasia",
      "count": 462
    },
    {
      "term": "Lethargy (see also Central nervous system depression in Neurological)",
      "count": 445
    },
    {
      "term": "Trembling",
      "count": 382
    },
    {
      "term": "Accidental exposure",
      "count": 376
    },
    {
      "term": "Dehydration",
      "count": 376
    },
    {
      "term": "Twitching",
      "count": 365
    },
    {
      "term": "Hyperactivity",
      "count": 345
    },
    {
      "term": "Application site scratching",
      "count": 321
    },
    {
      "term": "Application site reaction NOS",
      "count": 320
    },
    {
      "term": "Anaemia NOS",
      "count": 311
    },
    {
      "term": "Lack of efficacy - NOS",
      "count": 309
    },
    {
      "term": "Application site itching",
      "count": 301
    },
    {
      "term": "Convulsion",
      "count": 290
    },
    {
      "term": "Scratching",
      "count": 273
    },
    {
      "term": "Dermatitis",
      "count": 270
    },
    {
      "term": "Skin lesion NOS",
      "count": 255
    },
    {
      "term": "Tremor",
      "count": 252
    },
    {
      "term": "No sign",
      "count": 243
    },
    {
      "term": "Lack of efficacy (ectoparasite) - tick NOS",
      "count": 240
    },
    {
      "term": "Dyspnoea",
      "count": 238
    },
    {
      "term": "Itching",
      "count": 234
    },
    {
      "term": "Lack of efficacy (endoparasite) - roundworm NOS",
      "count": 233
    },
    {
      "term": "Application site bleeding",
      "count": 232
    },
    {
      "term": "Application site pain",
      "count": 232
    },
    {
      "term": "Hair loss NOS",
      "count": 232
    },
    {
      "term": "Drug dose administration interval too short",
      "count": 229
    },
    {
      "term": "INEFFECTIVE, HEARTWORM LARVAE",
      "count": 229
    },
    {
      "term": "Drooling",
      "count": 226
    },
    {
      "term": "Sneezing",
      "count": 223
    },
    {
      "term": "Elevated alanine aminotransferase (ALT)",
      "count": 220
    },
    {
      "term": "Other abnormal test result NOS",
      "count": 219
    },
    {
      "term": "Adipsia",
      "count": 211
    },
    {
      "term": "Leucocytosis NOS",
      "count": 207
    },
    {
      "term": "Hyperglycaemia",
      "count": 202
    },
    {
      "term": "Tachypnoea",
      "count": 200
    },
    {
      "term": "Abnormal radiograph finding",
      "count": 199
    },
    {
      "term": "Weakness",
      "count": 199
    },
    {
      "term": "Hypothermia",
      "count": 198
    },
    {
      "term": "Application site hair change",
      "count": 193
    },
    {
      "term": "Not drinking",
      "count": 191
    },
    {
      "term": "Application site sore",
      "count": 190
    },
    {
      "term": "Inappetence",
      "count": 190
    },
    {
      "term": "Underdose",
      "count": 189
    },
    {
      "term": "Overdose",
      "count": 188
    },
    {
      "term": "Application site crust",
      "count": 187
    },
    {
      "term": "Pain NOS",
      "count": 186
    },
    {
      "term": "Lack of efficacy (endoparasite) - hookworm",
      "count": 184
    },
    {
      "term": "Application site ulcer",
      "count": 179
    },
    {
      "term": "Lack of efficacy (flea)",
      "count": 176
    },
    {
      "term": "Elevated blood urea nitrogen (BUN)",
      "count": 174
    },
    {
      "term": "Shaking",
      "count": 173
    },
    {
      "term": "Drug administration error",
      "count": 170
    },
    {
      "term": "Emesis",
      "count": 158
    },
    {
      "term": "Elevated total bilirubin",
      "count": 156
    },
    {
      "term": "Localised hair loss",
      "count": 149
    },
    {
      "term": "Emesis (multiple)",
      "count": 146
    },
    {
      "term": "Panting",
      "count": 145
    },
    {
      "term": "Dilated pupils",
      "count": 143
    },
    {
      "term": "Restlessness",
      "count": 139
    },
    {
      "term": "Cough",
      "count": 138
    },
    {
      "term": "Crust",
      "count": 137
    },
    {
      "term": "Aggression",
      "count": 134
    },
    {
      "term": "Agitation",
      "count": 133
    },
    {
      "term": "Tachycardia",
      "count": 132
    },
    {
      "term": "Alopecia",
      "count": 131
    },
    {
      "term": "Ocular discharge",
      "count": 131
    },
    {
      "term": "Elevated creatinine",
      "count": 127
    }
  ]
}