{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-07-02"
  },
  "results": [
    {
      "term": "Vomiting",
      "count": 12831
    },
    {
      "term": "Seizure NOS",
      "count": 6910
    },
    {
      "term": "Lack of efficacy (bacteria) - Borrelia",
      "count": 6734
    },
    {
      "term": "Lack of efficacy (endoparasite) - heartworm",
      "count": 6095
    },
    {
      "term": "Diarrhoea",
      "count": 5215
    },
    {
      "term": "Lack of efficacy (endoparasite) - hookworm",
      "count": 4343
    },
    {
      "term": "Lack of efficacy (ectoparasite) - tick NOS",
      "count": 4174
    },
    {
      "term": "Lethargy (see also Central nervous system depression in 'Neurological')",
      "count": 3557
    },
    {
      "term": "Lack of efficacy (endoparasite) - roundworm NOS",
      "count": 3314
    },
    {
      "term": "Lack of efficacy (ectoparasite) - flea",
      "count": 2719
    },
    {
      "term": "Tremor",
      "count": 2382
    },
    {
      "term": "Lack of efficacy (endoparasite) - tapeworm",
      "count": 2326
    },
    {
      "term": "Ataxia",
      "count": 1986
    },
    {
      "term": "Lack of efficacy (bacteria) - Anaplasma",
      "count": 1876
    },
    {
      "term": "Intentional misuse",
      "count": 1801
    },
    {
      "term": "Lethargy (see also Central nervous system depression in Neurological)",
      "count": 1795
    },
    {
      "term": "Medication error NOS",
      "count": 1627
    },
    {
      "term": "Lack of efficacy (bacteria) - Ehrlichia",
      "count": 1407
    },
    {
      "term": "Anorexia",
      "count": 1366
    },
    {
      "term": "Not eating",
      "count": 1324
    },
    {
      "term": "Shaking",
      "count": 1221
    },
    {
      "term": "Behavioural disorder NOS",
      "count": 1182
    },
    {
      "term": "Emesis (multiple)",
      "count": 1168
    },
    {
      "term": "Lack of efficacy (bacteria) - NOS",
      "count": 1154
    },
    {
      "term": "Decreased appetite",
      "count": 987
    },
    {
      "term": "Lack of efficacy (endoparasite) - whipworm",
      "count": 894
    },
    {
      "term": "Lack of efficacy (tick)",
      "count": 852
    },
    {
      "term": "Twitching",
      "count": 820
    },
    {
      "term": "Overdose",
      "count": 715
    },
    {
      "term": "Panting",
      "count": 713
    },
    {
      "term": "Death",
      "count": 701
    },
    {
      "term": "Itching",
      "count": 682
    },
    {
      "term": "Death by euthanasia",
      "count": 668
    },
    {
      "term": "Not himself/herself",
      "count": 652
    },
    {
      "term": "Bloody diarrhoea",
      "count": 640
    },
    {
      "term": "Head tremor",
      "count": 601
    },
    {
      "term": "Disorientation",
      "count": 563
    },
    {
      "term": "Elevated alanine aminotransferase (ALT)",
      "count": 552
    },
    {
      "term": "Anxiety",
      "count": 517
    },
    {
      "term": "Pruritus",
      "count": 517
    },
    {
      "term": "Lack of efficacy (endoparasite) - NOS",
      "count": 516
    },
    {
      "term": "Loose stool",
      "count": 505
    },
    {
      "term": "Emesis",
      "count": 498
    },
    {
      "term": "Falling",
      "count": 494
    },
    {
      "term": "Weight loss",
      "count": 484
    },
    {
      "term": "Drooling",
      "count": 476
    },
    {
      "term": "Fever",
      "count": 467
    },
    {
      "term": "Inappetence",
      "count": 439
    },
    {
      "term": "Trembling",
      "count": 429
    },
    {
      "term": "Other abnormal test result NOS",
      "count": 404
    },
    {
      "term": "Walking difficulty",
      "count": 377
    },
    {
      "term": "Not drinking",
      "count": 376
    },
    {
      "term": "Vocalisation",
      "count": 374
    },
    {
      "term": "Lack of efficacy - NOS",
      "count": 359
    },
    {
      "term": "Polydipsia",
      "count": 346
    },
    {
      "term": "Inappropriate urination",
      "count": 324
    },
    {
      "term": "Hives (see also 'Skin')",
      "count": 320
    },
    {
      "term": "Underdose",
      "count": 311
    },
    {
      "term": "Muscle tremor",
      "count": 306
    },
    {
      "term": "Accidental exposure",
      "count": 305
    },
    {
      "term": "Dehydration",
      "count": 304
    },
    {
      "term": "Hyperactivity",
      "count": 302
    },
    {
      "term": "Restlessness",
      "count": 302
    },
    {
      "term": "Leucocytosis NOS",
      "count": 298
    },
    {
      "term": "Polyuria",
      "count": 294
    },
    {
      "term": "Weakness",
      "count": 285
    },
    {
      "term": "Aggression",
      "count": 280
    },
    {
      "term": "Urinary incontinence",
      "count": 274
    },
    {
      "term": "Neurological signs NOS",
      "count": 271
    },
    {
      "term": "Staring",
      "count": 271
    },
    {
      "term": "Nausea",
      "count": 265
    },
    {
      "term": "Cough",
      "count": 259
    },
    {
      "term": "Hypersalivation",
      "count": 259
    },
    {
      "term": "Facial swelling (see also 'Skin')",
      "count": 255
    },
    {
      "term": "Grand mal seizure",
      "count": 252
    },
    {
      "term": "Reddening of the skin",
      "count": 250
    },
    {
      "term": "Unable to stand",
      "count": 241
    },
    {
      "term": "Elevated serum alkaline phosphatase (SAP)",
      "count": 240
    },
    {
      "term": "Limb weakness",
      "count": 234
    },
    {
      "term": "Scratching",
      "count": 230
    },
    {
      "term": "Pain NOS",
      "count": 227
    },
    {
      "term": "Anaemia NOS",
      "count": 226
    },
    {
      "term": "Neutrophilia",
      "count": 225
    },
    {
      "term": "Pacing",
      "count": 214
    },
    {
      "term": "Foaming at the mouth",
      "count": 212
    },
    {
      "term": "Musculoskeletal disorder NOS",
      "count": 211
    },
    {
      "term": "Head bobbing",
      "count": 203
    },
    {
      "term": "Hiding",
      "count": 198
    },
    {
      "term": "Stumbling gait",
      "count": 192
    },
    {
      "term": "Elevated blood urea nitrogen (BUN)",
      "count": 189
    },
    {
      "term": "Abnormal radiograph finding",
      "count": 188
    },
    {
      "term": "Pale mucous membrane",
      "count": 186
    },
    {
      "term": "Elevated liver enzymes",
      "count": 182
    },
    {
      "term": "Adipsia",
      "count": 179
    },
    {
      "term": "Fly biting behaviour",
      "count": 179
    },
    {
      "term": "Reluctant to move",
      "count": 179
    },
    {
      "term": "Drug dose omission",
      "count": 178
    },
    {
      "term": "Hives (see also Skin)",
      "count": 178
    },
    {
      "term": "Appetite loss",
      "count": 176
    },
    {
      "term": "Blood in vomit",
      "count": 171
    }
  ]
}