{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-07-02"
  },
  "results": [
    {
      "term": "Application site hair loss",
      "count": 2294
    },
    {
      "term": "Application site alopecia",
      "count": 707
    },
    {
      "term": "Application site scab",
      "count": 686
    },
    {
      "term": "Lack of efficacy (ectoparasite) - flea",
      "count": 685
    },
    {
      "term": "Vomiting",
      "count": 682
    },
    {
      "term": "Lethargy (see also Central nervous system depression in 'Neurological')",
      "count": 678
    },
    {
      "term": "Application site reddening",
      "count": 489
    },
    {
      "term": "Application site irritation",
      "count": 343
    },
    {
      "term": "Seizure NOS",
      "count": 337
    },
    {
      "term": "Lethargy (see also Central nervous system depression in Neurological)",
      "count": 326
    },
    {
      "term": "Anorexia",
      "count": 303
    },
    {
      "term": "Not eating",
      "count": 291
    },
    {
      "term": "Behavioural disorder NOS",
      "count": 280
    },
    {
      "term": "Diarrhoea",
      "count": 277
    },
    {
      "term": "Application site burn",
      "count": 263
    },
    {
      "term": "Lack of efficacy (endoparasite) - tapeworm",
      "count": 246
    },
    {
      "term": "Ataxia",
      "count": 224
    },
    {
      "term": "Decreased appetite",
      "count": 219
    },
    {
      "term": "Hiding",
      "count": 202
    },
    {
      "term": "Application site lesion",
      "count": 192
    },
    {
      "term": "Tremor",
      "count": 189
    },
    {
      "term": "Fever",
      "count": 171
    },
    {
      "term": "Weight loss",
      "count": 167
    },
    {
      "term": "Twitching",
      "count": 164
    },
    {
      "term": "Application site itching",
      "count": 150
    },
    {
      "term": "Lack of efficacy (endoparasite) - roundworm NOS",
      "count": 149
    },
    {
      "term": "Vocalisation",
      "count": 146
    },
    {
      "term": "Application site scratching",
      "count": 142
    },
    {
      "term": "Pruritus",
      "count": 136
    },
    {
      "term": "Itching",
      "count": 135
    },
    {
      "term": "Application site erythema",
      "count": 134
    },
    {
      "term": "Accidental exposure",
      "count": 130
    },
    {
      "term": "Drooling",
      "count": 130
    },
    {
      "term": "Lack of efficacy (ectoparasite) - tick NOS",
      "count": 130
    },
    {
      "term": "Application site sore",
      "count": 127
    },
    {
      "term": "Scratching",
      "count": 123
    },
    {
      "term": "Application site pruritus",
      "count": 122
    },
    {
      "term": "Death",
      "count": 118
    },
    {
      "term": "Not himself/herself",
      "count": 113
    },
    {
      "term": "Overdose",
      "count": 106
    },
    {
      "term": "Application site inflammation",
      "count": 105
    },
    {
      "term": "Application site bleeding",
      "count": 104
    },
    {
      "term": "Hair loss NOS",
      "count": 102
    },
    {
      "term": "Panting",
      "count": 102
    },
    {
      "term": "Hyperactivity",
      "count": 94
    },
    {
      "term": "Not drinking",
      "count": 92
    },
    {
      "term": "Skin scab",
      "count": 88
    },
    {
      "term": "Emesis (multiple)",
      "count": 87
    },
    {
      "term": "Application site rash",
      "count": 83
    },
    {
      "term": "Dehydration",
      "count": 83
    },
    {
      "term": "Lack of efficacy (endoparasite) - heartworm",
      "count": 82
    },
    {
      "term": "Intentional misuse",
      "count": 81
    },
    {
      "term": "Hypersalivation",
      "count": 80
    },
    {
      "term": "Sneezing",
      "count": 80
    },
    {
      "term": "Death by euthanasia",
      "count": 79
    },
    {
      "term": "Dilated pupils",
      "count": 75
    },
    {
      "term": "Underdose",
      "count": 75
    },
    {
      "term": "Application site ulcer",
      "count": 74
    },
    {
      "term": "Lack of efficacy (ectoparasite) - ear mite",
      "count": 74
    },
    {
      "term": "Localised hair loss",
      "count": 73
    },
    {
      "term": "Application site pain",
      "count": 68
    },
    {
      "term": "Medication error NOS",
      "count": 65
    },
    {
      "term": "Skin lesion NOS",
      "count": 63
    },
    {
      "term": "Shaking",
      "count": 62
    },
    {
      "term": "Application site crust",
      "count": 59
    },
    {
      "term": "Agitation",
      "count": 58
    },
    {
      "term": "Inappetence",
      "count": 58
    },
    {
      "term": "Lack of efficacy - NOS",
      "count": 58
    },
    {
      "term": "Hyperglycaemia",
      "count": 57
    },
    {
      "term": "Pain NOS",
      "count": 53
    },
    {
      "term": "Disorientation",
      "count": 50
    },
    {
      "term": "Reddening of the skin",
      "count": 50
    },
    {
      "term": "Alopecia",
      "count": 49
    },
    {
      "term": "Anaemia NOS",
      "count": 49
    },
    {
      "term": "Adipsia",
      "count": 48
    },
    {
      "term": "Application site reaction NOS",
      "count": 48
    },
    {
      "term": "Application site blister",
      "count": 47
    },
    {
      "term": "Foaming at the mouth",
      "count": 47
    },
    {
      "term": "Head tremor",
      "count": 45
    },
    {
      "term": "Licking at application site",
      "count": 44
    },
    {
      "term": "Excessive chewing, licking and/or grooming",
      "count": 43
    },
    {
      "term": "Sleepiness - systemic disorder",
      "count": 42
    },
    {
      "term": "Inappropriate urination",
      "count": 39
    },
    {
      "term": "Open mouth breathing",
      "count": 39
    },
    {
      "term": "Tachypnoea",
      "count": 39
    },
    {
      "term": "General hair loss",
      "count": 38
    },
    {
      "term": "Odor, Abnormal",
      "count": 38
    },
    {
      "term": "Falling",
      "count": 37
    },
    {
      "term": "Hyperaesthesia",
      "count": 37
    },
    {
      "term": "Ocular discharge",
      "count": 37
    },
    {
      "term": "Lack of efficacy (endoparasite) - hookworm",
      "count": 36
    },
    {
      "term": "Other abnormal test result NOS",
      "count": 36
    },
    {
      "term": "Application site dermatitis",
      "count": 35
    },
    {
      "term": "Elevated alanine aminotransferase (ALT)",
      "count": 35
    },
    {
      "term": "Licking",
      "count": 35
    },
    {
      "term": "Application site hair change",
      "count": 34
    },
    {
      "term": "Generalised itching",
      "count": 34
    },
    {
      "term": "Muscle tremor",
      "count": 34
    },
    {
      "term": "Cough",
      "count": 33
    },
    {
      "term": "Elevated total bilirubin",
      "count": 32
    }
  ]
}