{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-07-02"
  },
  "results": [
    {
      "term": "Lack of efficacy - NOS",
      "count": 189
    },
    {
      "term": "Loss of hearing",
      "count": 64
    },
    {
      "term": "Deafness",
      "count": 58
    },
    {
      "term": "Ear discharge",
      "count": 50
    },
    {
      "term": "Ataxia",
      "count": 46
    },
    {
      "term": "Behavioural disorder NOS",
      "count": 44
    },
    {
      "term": "Lethargy (see also Central nervous system depression in 'Neurological')",
      "count": 39
    },
    {
      "term": "Vomiting",
      "count": 39
    },
    {
      "term": "Head tilt - ear disorder",
      "count": 36
    },
    {
      "term": "Corneal ulcer",
      "count": 34
    },
    {
      "term": "Anorexia",
      "count": 26
    },
    {
      "term": "Ear pain",
      "count": 26
    },
    {
      "term": "Head shake - ear disorder",
      "count": 26
    },
    {
      "term": "Other abnormal test result NOS",
      "count": 26
    },
    {
      "term": "Ear infection NOS",
      "count": 23
    },
    {
      "term": "Nystagmus",
      "count": 23
    },
    {
      "term": "Abnormal cytology",
      "count": 21
    },
    {
      "term": "Decreased appetite",
      "count": 21
    },
    {
      "term": "Impaired hearing",
      "count": 21
    },
    {
      "term": "Keratoconjunctivitis sicca",
      "count": 21
    },
    {
      "term": "Lethargy (see also Central nervous system depression in Neurological)",
      "count": 21
    },
    {
      "term": "Other ear disorder NOS",
      "count": 21
    },
    {
      "term": "Ear canal erythema",
      "count": 20
    },
    {
      "term": "Otitis externa",
      "count": 20
    },
    {
      "term": "Application site erythema",
      "count": 19
    },
    {
      "term": "Diarrhoea",
      "count": 18
    },
    {
      "term": "Vestibular disorder NOS",
      "count": 18
    },
    {
      "term": "Ear canal inflammation",
      "count": 17
    },
    {
      "term": "Hearing decreased",
      "count": 17
    },
    {
      "term": "Tympanic rupture",
      "count": 17
    },
    {
      "term": "Dry eye",
      "count": 15
    },
    {
      "term": "Emesis (multiple)",
      "count": 15
    },
    {
      "term": "Eye disorder NOS (for photophobia see 'neurological')",
      "count": 14
    },
    {
      "term": "Lack of efficacy (bacteria) - NOS",
      "count": 14
    },
    {
      "term": "Ocular discharge",
      "count": 14
    },
    {
      "term": "Otorrhoea",
      "count": 14
    },
    {
      "term": "Squinting",
      "count": 14
    },
    {
      "term": "Dry nose",
      "count": 13
    },
    {
      "term": "Panting",
      "count": 13
    },
    {
      "term": "Ear pruritus",
      "count": 12
    },
    {
      "term": "Nasal discharge",
      "count": 12
    },
    {
      "term": "Partial deafness",
      "count": 12
    },
    {
      "term": "Seizure NOS",
      "count": 12
    },
    {
      "term": "Anxiety",
      "count": 11
    },
    {
      "term": "Blepharospasm",
      "count": 11
    },
    {
      "term": "CULTURE/TITER DATA ABNORMAL",
      "count": 11
    },
    {
      "term": "Facial paralysis",
      "count": 11
    },
    {
      "term": "Inappropriate urination",
      "count": 11
    },
    {
      "term": "Pain NOS",
      "count": 11
    },
    {
      "term": "Schirmer tear test",
      "count": 11
    },
    {
      "term": "Scratching",
      "count": 11
    },
    {
      "term": "Vocalisation",
      "count": 11
    },
    {
      "term": "Abnormal radiograph finding",
      "count": 10
    },
    {
      "term": "Corneal disorder NOS",
      "count": 10
    },
    {
      "term": "Crust",
      "count": 10
    },
    {
      "term": "Death",
      "count": 10
    },
    {
      "term": "Disorientation",
      "count": 10
    },
    {
      "term": "Erythema (for urticaria see Immune SOC)",
      "count": 10
    },
    {
      "term": "Fever",
      "count": 10
    },
    {
      "term": "Not eating",
      "count": 10
    },
    {
      "term": "Pinnal erythema",
      "count": 10
    },
    {
      "term": "Pruritus",
      "count": 10
    },
    {
      "term": "Restlessness",
      "count": 10
    },
    {
      "term": "Swollen ear canal",
      "count": 10
    },
    {
      "term": "Application site pain",
      "count": 9
    },
    {
      "term": "Circling - neurological disorder (see also 'Behavioural disorders')",
      "count": 9
    },
    {
      "term": "Death by euthanasia",
      "count": 9
    },
    {
      "term": "Emesis",
      "count": 9
    },
    {
      "term": "Lack of efficacy (fungi) - NOS",
      "count": 9
    },
    {
      "term": "Lymphopenia",
      "count": 9
    },
    {
      "term": "Neutrophilia",
      "count": 9
    },
    {
      "term": "Otitis media",
      "count": 9
    },
    {
      "term": "Conjunctivitis",
      "count": 8
    },
    {
      "term": "Cough",
      "count": 8
    },
    {
      "term": "Dehydration",
      "count": 8
    },
    {
      "term": "Ear canal disorder",
      "count": 8
    },
    {
      "term": "Head tilt - neurological disorder (see also Head tilt - ear disorder)",
      "count": 8
    },
    {
      "term": "Horizontal nystagmus",
      "count": 8
    },
    {
      "term": "Neurogenic keratoconjunctivitis sicca (KCS)",
      "count": 8
    },
    {
      "term": "Abnormal Schirmer tear test",
      "count": 7
    },
    {
      "term": "Abnormal ultrasound finding",
      "count": 7
    },
    {
      "term": "Agitation",
      "count": 7
    },
    {
      "term": "Anaemia NOS",
      "count": 7
    },
    {
      "term": "Application site irritation",
      "count": 7
    },
    {
      "term": "Corneal oedema",
      "count": 7
    },
    {
      "term": "Elevated alanine aminotransferase (ALT)",
      "count": 7
    },
    {
      "term": "Internal ear disorder",
      "count": 7
    },
    {
      "term": "Keratitis",
      "count": 7
    },
    {
      "term": "Leucocytosis NOS",
      "count": 7
    },
    {
      "term": "Monocytosis",
      "count": 7
    },
    {
      "term": "Tympanic alteration",
      "count": 7
    },
    {
      "term": "Uncomfortable",
      "count": 7
    },
    {
      "term": "Application site inflammation",
      "count": 6
    },
    {
      "term": "Balance problem",
      "count": 6
    },
    {
      "term": "Drooling",
      "count": 6
    },
    {
      "term": "Hypoalbuminaemia",
      "count": 6
    },
    {
      "term": "Inappetence",
      "count": 6
    },
    {
      "term": "Mucus in eye",
      "count": 6
    },
    {
      "term": "Otitis NOS",
      "count": 6
    },
    {
      "term": "Reddening of the skin",
      "count": 6
    }
  ]
}