{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-07-02"
  },
  "results": [
    {
      "term": "Diarrhoea",
      "count": 164
    },
    {
      "term": "Anorexia",
      "count": 147
    },
    {
      "term": "Death by euthanasia",
      "count": 140
    },
    {
      "term": "Lack of efficacy - NOS",
      "count": 125
    },
    {
      "term": "Lethargy (see also Central nervous system depression in 'Neurological')",
      "count": 118
    },
    {
      "term": "Weight loss",
      "count": 99
    },
    {
      "term": "Decreased appetite",
      "count": 67
    },
    {
      "term": "Lack of efficacy (neoplasia, no remission)",
      "count": 67
    },
    {
      "term": "Neutropenia",
      "count": 62
    },
    {
      "term": "Vomiting",
      "count": 57
    },
    {
      "term": "Death",
      "count": 52
    },
    {
      "term": "Elevated alanine aminotransferase (ALT)",
      "count": 50
    },
    {
      "term": "Alopecia",
      "count": 49
    },
    {
      "term": "Elevated liver enzymes",
      "count": 49
    },
    {
      "term": "Thrombocytopenia",
      "count": 47
    },
    {
      "term": "Neutrophilia",
      "count": 45
    },
    {
      "term": "Erythema (for urticaria see Immune SOC)",
      "count": 35
    },
    {
      "term": "Hyperpigmentation",
      "count": 35
    },
    {
      "term": "Anaemia NOS",
      "count": 32
    },
    {
      "term": "Elevated blood urea nitrogen (BUN)",
      "count": 31
    },
    {
      "term": "Nausea",
      "count": 31
    },
    {
      "term": "Bloody diarrhoea",
      "count": 28
    },
    {
      "term": "Elevated creatinine",
      "count": 28
    },
    {
      "term": "Fever",
      "count": 28
    },
    {
      "term": "Leucocytosis NOS",
      "count": 28
    },
    {
      "term": "Monocytosis",
      "count": 28
    },
    {
      "term": "Dermatitis",
      "count": 26
    },
    {
      "term": "Emesis",
      "count": 25
    },
    {
      "term": "Pruritus",
      "count": 25
    },
    {
      "term": "Leucopenia NOS",
      "count": 23
    },
    {
      "term": "Lymphopenia",
      "count": 23
    },
    {
      "term": "Otitis externa",
      "count": 23
    },
    {
      "term": "Cough",
      "count": 22
    },
    {
      "term": "Pulmonary fibrosis",
      "count": 22
    },
    {
      "term": "Dehydration",
      "count": 20
    },
    {
      "term": "Glucosuria",
      "count": 20
    },
    {
      "term": "Polydipsia",
      "count": 20
    },
    {
      "term": "Elevated serum alkaline phosphatase (SAP)",
      "count": 19
    },
    {
      "term": "Dyspnoea",
      "count": 18
    },
    {
      "term": "Skin lesion NOS",
      "count": 18
    },
    {
      "term": "Elevated gamma-glutamyl transferase (GGT)",
      "count": 17
    },
    {
      "term": "Inappetence",
      "count": 17
    },
    {
      "term": "Polyuria",
      "count": 17
    },
    {
      "term": "Proteinuria",
      "count": 17
    },
    {
      "term": "Pyoderma",
      "count": 17
    },
    {
      "term": "Ulcerative dermatitis",
      "count": 17
    },
    {
      "term": "Elevated total bilirubin",
      "count": 16
    },
    {
      "term": "Abnormal radiograph finding",
      "count": 15
    },
    {
      "term": "Crust",
      "count": 15
    },
    {
      "term": "Otitis NOS",
      "count": 15
    },
    {
      "term": "Decreased haemoglobin",
      "count": 14
    },
    {
      "term": "Haematochezia",
      "count": 14
    },
    {
      "term": "Tachypnoea",
      "count": 14
    },
    {
      "term": "Hypoalbuminaemia",
      "count": 13
    },
    {
      "term": "Lethargy (see also Central nervous system depression in Neurological)",
      "count": 13
    },
    {
      "term": "Urinary tract infection",
      "count": 13
    },
    {
      "term": "Emesis (multiple)",
      "count": 12
    },
    {
      "term": "Hypokalaemia",
      "count": 12
    },
    {
      "term": "Partial lack of efficacy",
      "count": 12
    },
    {
      "term": "Pneumonia",
      "count": 12
    },
    {
      "term": "Alopecia local",
      "count": 11
    },
    {
      "term": "Decreased packed cell volume (PCV)",
      "count": 11
    },
    {
      "term": "Hair loss NOS",
      "count": 11
    },
    {
      "term": "Hyperphosphataemia",
      "count": 11
    },
    {
      "term": "Alopecia NOS",
      "count": 10
    },
    {
      "term": "Breathing difficulty",
      "count": 10
    },
    {
      "term": "Dermatosis NOS",
      "count": 10
    },
    {
      "term": "Elevated cholesterol (total)",
      "count": 10
    },
    {
      "term": "Excoriation",
      "count": 10
    },
    {
      "term": "Injection site complication NOS",
      "count": 10
    },
    {
      "term": "Partial anorexia",
      "count": 10
    },
    {
      "term": "Reddening of the skin",
      "count": 10
    },
    {
      "term": "Regurgitation",
      "count": 10
    },
    {
      "term": "Appetite loss",
      "count": 9
    },
    {
      "term": "Hyperglycaemia",
      "count": 9
    },
    {
      "term": "Loose stool",
      "count": 9
    },
    {
      "term": "Pain NOS",
      "count": 9
    },
    {
      "term": "Respiratory distress",
      "count": 9
    },
    {
      "term": "Scale",
      "count": 9
    },
    {
      "term": "Seizure NOS",
      "count": 9
    },
    {
      "term": "Skin scab",
      "count": 9
    },
    {
      "term": "Weakness",
      "count": 9
    },
    {
      "term": "Digestive tract disorder NOS",
      "count": 8
    },
    {
      "term": "Elevated aspartate aminotransferase (AST)",
      "count": 8
    },
    {
      "term": "Panting",
      "count": 8
    },
    {
      "term": "Skin disorders NOS",
      "count": 8
    },
    {
      "term": "Skin ulcer",
      "count": 8
    },
    {
      "term": "Tachycardia",
      "count": 8
    },
    {
      "term": "Abnormal breathing",
      "count": 7
    },
    {
      "term": "Alopecia general",
      "count": 7
    },
    {
      "term": "Azotaemia",
      "count": 7
    },
    {
      "term": "Colitis",
      "count": 7
    },
    {
      "term": "Enlarged lymph node (localised)",
      "count": 7
    },
    {
      "term": "Moist dermatitis",
      "count": 7
    },
    {
      "term": "Non-regenerative anaemia",
      "count": 7
    },
    {
      "term": "Skin slough",
      "count": 7
    },
    {
      "term": "Collapse (see also 'Cardio-vascular' and 'Systemic disorders')",
      "count": 6
    },
    {
      "term": "Hot spot (pyotraumatic dermatitis)",
      "count": 6
    },
    {
      "term": "Hypercalcaemia",
      "count": 6
    },
    {
      "term": "Hypoproteinaemia",
      "count": 6
    }
  ]
}