{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-07-02"
  },
  "results": [
    {
      "term": "Vomiting",
      "count": 37307
    },
    {
      "term": "INEFFECTIVE, HEARTWORM LARVAE",
      "count": 35850
    },
    {
      "term": "Lack of efficacy (endoparasite) - hookworm",
      "count": 31823
    },
    {
      "term": "Lack of efficacy (endoparasite) - heartworm",
      "count": 28953
    },
    {
      "term": "Digestive tract disorder NOS",
      "count": 16793
    },
    {
      "term": "Diarrhoea",
      "count": 15908
    },
    {
      "term": "INEFFECTIVE, ASCARIDS NOS",
      "count": 11932
    },
    {
      "term": "Cardiac disorder NOS",
      "count": 10065
    },
    {
      "term": "Lethargy (see also Central nervous system depression in 'Neurological')",
      "count": 9427
    },
    {
      "term": "Lack of efficacy (endoparasite) - roundworm NOS",
      "count": 9179
    },
    {
      "term": "Lack of efficacy - NOS",
      "count": 8770
    },
    {
      "term": "Seizure NOS",
      "count": 7555
    },
    {
      "term": "INEFFECTIVE, HOOKS",
      "count": 7207
    },
    {
      "term": "Lack of efficacy (bacteria) - Borrelia",
      "count": 6998
    },
    {
      "term": "Lack of efficacy (endoparasite) - tapeworm",
      "count": 4134
    },
    {
      "term": "Anorexia",
      "count": 4102
    },
    {
      "term": "Lack of efficacy (ectoparasite) - tick NOS",
      "count": 3554
    },
    {
      "term": "Death",
      "count": 3266
    },
    {
      "term": "Lethargy (see also Central nervous system depression in Neurological)",
      "count": 3254
    },
    {
      "term": "Emesis",
      "count": 3240
    },
    {
      "term": "Emesis (multiple)",
      "count": 3136
    },
    {
      "term": "Not eating",
      "count": 3056
    },
    {
      "term": "Lack of efficacy (endoparasite) - whipworm",
      "count": 2847
    },
    {
      "term": "Ataxia",
      "count": 2771
    },
    {
      "term": "Behavioural disorder NOS",
      "count": 2762
    },
    {
      "term": "Lack of efficacy (protozoa) - Coccidia",
      "count": 2719
    },
    {
      "term": "Overdose",
      "count": 2696
    },
    {
      "term": "Lack of efficacy (ectoparasite) - flea",
      "count": 2583
    },
    {
      "term": "Depression",
      "count": 2570
    },
    {
      "term": "Underdose",
      "count": 2526
    },
    {
      "term": "Shaking",
      "count": 2336
    },
    {
      "term": "Loose stool",
      "count": 2251
    },
    {
      "term": "Other abnormal test result NOS",
      "count": 2220
    },
    {
      "term": "Lack of efficacy (bacteria) - Anaplasma",
      "count": 2171
    },
    {
      "term": "Bloody diarrhoea",
      "count": 2132
    },
    {
      "term": "Death by euthanasia",
      "count": 1784
    },
    {
      "term": "Decreased appetite",
      "count": 1780
    },
    {
      "term": "Intentional misuse",
      "count": 1710
    },
    {
      "term": "Panting",
      "count": 1658
    },
    {
      "term": "Tremor",
      "count": 1598
    },
    {
      "term": "Medication error NOS",
      "count": 1596
    },
    {
      "term": "Itching",
      "count": 1561
    },
    {
      "term": "Lack of efficacy (bacteria) - Ehrlichia",
      "count": 1513
    },
    {
      "term": "Weight loss",
      "count": 1483
    },
    {
      "term": "Pruritus",
      "count": 1474
    },
    {
      "term": "Elevated alanine aminotransferase (ALT)",
      "count": 1400
    },
    {
      "term": "Vocalisation",
      "count": 1213
    },
    {
      "term": "Cough",
      "count": 1212
    },
    {
      "term": "Inappetence",
      "count": 1161
    },
    {
      "term": "Lack of efficacy (bacteria) - NOS",
      "count": 1158
    },
    {
      "term": "Trembling",
      "count": 1128
    },
    {
      "term": "INEFFECTIVE, HEARTWORM ADULTS",
      "count": 1105
    },
    {
      "term": "Hypersalivation",
      "count": 1086
    },
    {
      "term": "Drooling",
      "count": 1076
    },
    {
      "term": "Accidental exposure",
      "count": 1045
    },
    {
      "term": "Fever",
      "count": 1036
    },
    {
      "term": "Convulsion",
      "count": 983
    },
    {
      "term": "Lack of efficacy (endoparasite) - NOS",
      "count": 977
    },
    {
      "term": "Hyperactivity",
      "count": 972
    },
    {
      "term": "Drug dose administration interval too long",
      "count": 959
    },
    {
      "term": "Restlessness",
      "count": 944
    },
    {
      "term": "INEFFECTIVE, COCCIDIA",
      "count": 876
    },
    {
      "term": "Anxiety",
      "count": 859
    },
    {
      "term": "Not drinking",
      "count": 845
    },
    {
      "term": "No sign",
      "count": 839
    },
    {
      "term": "UNPALATABLE",
      "count": 815
    },
    {
      "term": "Twitching",
      "count": 812
    },
    {
      "term": "INEFFECTIVE, WHIPS",
      "count": 802
    },
    {
      "term": "Abnormal radiograph finding",
      "count": 781
    },
    {
      "term": "Disorientation",
      "count": 776
    },
    {
      "term": "Polydipsia",
      "count": 761
    },
    {
      "term": "Not himself/herself",
      "count": 754
    },
    {
      "term": "Dehydration",
      "count": 749
    },
    {
      "term": "Leucocytosis NOS",
      "count": 743
    },
    {
      "term": "Elevated serum alkaline phosphatase (SAP)",
      "count": 730
    },
    {
      "term": "Inappropriate urination",
      "count": 728
    },
    {
      "term": "Pale mucous membrane",
      "count": 715
    },
    {
      "term": "Weakness",
      "count": 706
    },
    {
      "term": "Weight gain",
      "count": 700
    },
    {
      "term": "Drug dose omission",
      "count": 699
    },
    {
      "term": "Lack of efficacy (roundworm)",
      "count": 696
    },
    {
      "term": "Scratching",
      "count": 692
    },
    {
      "term": "Falling",
      "count": 654
    },
    {
      "term": "Pain NOS",
      "count": 622
    },
    {
      "term": "Head tremor",
      "count": 619
    },
    {
      "term": "Anaemia NOS",
      "count": 612
    },
    {
      "term": "Neutrophilia",
      "count": 609
    },
    {
      "term": "Walking difficulty",
      "count": 607
    },
    {
      "term": "Hives (see also 'Skin')",
      "count": 545
    },
    {
      "term": "Blood in faeces",
      "count": 535
    },
    {
      "term": "Polyuria",
      "count": 534
    },
    {
      "term": "Elevated blood urea nitrogen (BUN)",
      "count": 530
    },
    {
      "term": "Facial swelling (see also 'Skin')",
      "count": 526
    },
    {
      "term": "Nausea",
      "count": 526
    },
    {
      "term": "Aggression",
      "count": 512
    },
    {
      "term": "Reluctant to move",
      "count": 504
    },
    {
      "term": "Appetite loss",
      "count": 503
    },
    {
      "term": "Foaming at the mouth",
      "count": 487
    },
    {
      "term": "Anaphylaxis",
      "count": 482
    },
    {
      "term": "Adipsia",
      "count": 480
    }
  ]
}