{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-07-02"
  },
  "results": [
    {
      "term": "Vomiting",
      "count": 539
    },
    {
      "term": "Lack of efficacy - NOS",
      "count": 498
    },
    {
      "term": "Lethargy (see also Central nervous system depression in 'Neurological')",
      "count": 398
    },
    {
      "term": "Diarrhoea",
      "count": 296
    },
    {
      "term": "Emesis",
      "count": 283
    },
    {
      "term": "Deafness",
      "count": 269
    },
    {
      "term": "Other abnormal test result NOS",
      "count": 260
    },
    {
      "term": "Anorexia",
      "count": 254
    },
    {
      "term": "Loss of hearing",
      "count": 253
    },
    {
      "term": "Elevated serum alkaline phosphatase (SAP)",
      "count": 219
    },
    {
      "term": "Elevated alanine aminotransferase (ALT)",
      "count": 197
    },
    {
      "term": "Death by euthanasia",
      "count": 196
    },
    {
      "term": "Polydipsia",
      "count": 188
    },
    {
      "term": "Death",
      "count": 177
    },
    {
      "term": "Polyuria",
      "count": 164
    },
    {
      "term": "Behavioural disorder NOS",
      "count": 163
    },
    {
      "term": "Seizure NOS",
      "count": 147
    },
    {
      "term": "Weight loss",
      "count": 147
    },
    {
      "term": "Anaemia NOS",
      "count": 139
    },
    {
      "term": "Leucocytosis NOS",
      "count": 137
    },
    {
      "term": "Depression",
      "count": 120
    },
    {
      "term": "Ataxia",
      "count": 119
    },
    {
      "term": "Decreased appetite",
      "count": 118
    },
    {
      "term": "Abnormal radiograph finding",
      "count": 117
    },
    {
      "term": "INEFFECTIVE, LOSS OF EFFECT",
      "count": 115
    },
    {
      "term": "Fever",
      "count": 114
    },
    {
      "term": "Cough",
      "count": 113
    },
    {
      "term": "INEFFECTIVE, ATOPY CONTROL",
      "count": 112
    },
    {
      "term": "Not eating",
      "count": 112
    },
    {
      "term": "Panting",
      "count": 112
    },
    {
      "term": "Pruritus",
      "count": 107
    },
    {
      "term": "Lethargy (see also Central nervous system depression in Neurological)",
      "count": 105
    },
    {
      "term": "Elevated liver enzymes",
      "count": 103
    },
    {
      "term": "Neutrophilia",
      "count": 100
    },
    {
      "term": "Impaired hearing",
      "count": 98
    },
    {
      "term": "Elevated blood urea nitrogen (BUN)",
      "count": 97
    },
    {
      "term": "Hearing decreased",
      "count": 89
    },
    {
      "term": "Skin lesion NOS",
      "count": 85
    },
    {
      "term": "Shaking",
      "count": 83
    },
    {
      "term": "Lack of efficacy (endoparasite) - heartworm",
      "count": 82
    },
    {
      "term": "Thrombocytopenia",
      "count": 82
    },
    {
      "term": "Bloody diarrhoea",
      "count": 78
    },
    {
      "term": "Ear infection NOS",
      "count": 77
    },
    {
      "term": "Erythema (for urticaria see Immune SOC)",
      "count": 74
    },
    {
      "term": "Pale mucous membrane",
      "count": 74
    },
    {
      "term": "Weakness",
      "count": 74
    },
    {
      "term": "Underdose",
      "count": 73
    },
    {
      "term": "Vocalisation",
      "count": 72
    },
    {
      "term": "Abnormal ultrasound finding",
      "count": 71
    },
    {
      "term": "Pain NOS",
      "count": 68
    },
    {
      "term": "Elevated creatinine",
      "count": 64
    },
    {
      "term": "Trembling",
      "count": 63
    },
    {
      "term": "Elevated total bilirubin",
      "count": 61
    },
    {
      "term": "Abnormal cytology",
      "count": 60
    },
    {
      "term": "Dehydration",
      "count": 60
    },
    {
      "term": "Hypoalbuminaemia",
      "count": 59
    },
    {
      "term": "Weight gain",
      "count": 59
    },
    {
      "term": "Anxiety",
      "count": 58
    },
    {
      "term": "Overdose",
      "count": 57
    },
    {
      "term": "Hyperglycaemia",
      "count": 56
    },
    {
      "term": "Loose stool",
      "count": 56
    },
    {
      "term": "INEFFECTIVE, ANTIINFLAMMATORY",
      "count": 54
    },
    {
      "term": "Inappetence",
      "count": 54
    },
    {
      "term": "Ear discharge",
      "count": 53
    },
    {
      "term": "Inappropriate urination",
      "count": 53
    },
    {
      "term": "Lack of efficacy (ectoparasite) - flea",
      "count": 53
    },
    {
      "term": "Urinary incontinence",
      "count": 53
    },
    {
      "term": "Restlessness",
      "count": 52
    },
    {
      "term": "Monocytosis",
      "count": 51
    },
    {
      "term": "Partial deafness",
      "count": 51
    },
    {
      "term": "Skin disorders NOS",
      "count": 48
    },
    {
      "term": "Otitis externa",
      "count": 47
    },
    {
      "term": "Dyspnoea",
      "count": 46
    },
    {
      "term": "Elevated serum alkaline phosphatase (ALP)",
      "count": 46
    },
    {
      "term": "Facial swelling (see also 'Skin')",
      "count": 45
    },
    {
      "term": "Aggression",
      "count": 44
    },
    {
      "term": "Urinary tract infection",
      "count": 44
    },
    {
      "term": "Elevated gamma-glutamyl transferase (GGT)",
      "count": 43
    },
    {
      "term": "Emesis (multiple)",
      "count": 42
    },
    {
      "term": "Hyperphosphataemia",
      "count": 42
    },
    {
      "term": "Proteinuria",
      "count": 41
    },
    {
      "term": "Dermatitis",
      "count": 38
    },
    {
      "term": "Itching",
      "count": 38
    },
    {
      "term": "Lymphopenia",
      "count": 38
    },
    {
      "term": "Not drinking",
      "count": 38
    },
    {
      "term": "PR-SKIN, LESION(S)",
      "count": 38
    },
    {
      "term": "Tachycardia",
      "count": 38
    },
    {
      "term": "Decreased urine concentration",
      "count": 37
    },
    {
      "term": "Disorientation",
      "count": 37
    },
    {
      "term": "Hives (see also 'Skin')",
      "count": 37
    },
    {
      "term": "Urticaria",
      "count": 37
    },
    {
      "term": "Anaphylaxis",
      "count": 36
    },
    {
      "term": "Lymphadenopathy",
      "count": 36
    },
    {
      "term": "Reddening of the skin",
      "count": 36
    },
    {
      "term": "Injection site swelling",
      "count": 35
    },
    {
      "term": "Leucopenia NOS",
      "count": 35
    },
    {
      "term": "Sneezing",
      "count": 35
    },
    {
      "term": "Breathing difficulty",
      "count": 34
    },
    {
      "term": "Distension of abdomen",
      "count": 34
    },
    {
      "term": "Elevated amylase",
      "count": 34
    }
  ]
}