{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-07-02"
  },
  "results": [
    {
      "term": "Vomiting",
      "count": 496
    },
    {
      "term": "Lack of efficacy - NOS",
      "count": 451
    },
    {
      "term": "Lethargy (see also Central nervous system depression in 'Neurological')",
      "count": 449
    },
    {
      "term": "Emesis",
      "count": 425
    },
    {
      "term": "Panting",
      "count": 311
    },
    {
      "term": "Accidental exposure",
      "count": 309
    },
    {
      "term": "Diarrhoea",
      "count": 297
    },
    {
      "term": "Agitation",
      "count": 250
    },
    {
      "term": "Overdose",
      "count": 233
    },
    {
      "term": "Anorexia",
      "count": 228
    },
    {
      "term": "Emesis (multiple)",
      "count": 195
    },
    {
      "term": "Underdose",
      "count": 191
    },
    {
      "term": "Death by euthanasia",
      "count": 162
    },
    {
      "term": "Ataxia",
      "count": 151
    },
    {
      "term": "Erythema (for urticaria see Immune SOC)",
      "count": 146
    },
    {
      "term": "Hypertension",
      "count": 143
    },
    {
      "term": "Elevated alanine aminotransferase (ALT)",
      "count": 139
    },
    {
      "term": "Seizure NOS",
      "count": 138
    },
    {
      "term": "Mydriasis",
      "count": 122
    },
    {
      "term": "Polydipsia",
      "count": 119
    },
    {
      "term": "Decreased appetite",
      "count": 118
    },
    {
      "term": "Restlessness",
      "count": 115
    },
    {
      "term": "Urinary incontinence",
      "count": 110
    },
    {
      "term": "Behavioural disorder NOS",
      "count": 108
    },
    {
      "term": "Weight loss",
      "count": 100
    },
    {
      "term": "Death",
      "count": 90
    },
    {
      "term": "Elevated serum alkaline phosphatase (SAP)",
      "count": 90
    },
    {
      "term": "Piloerection",
      "count": 89
    },
    {
      "term": "Elevated blood urea nitrogen (BUN)",
      "count": 83
    },
    {
      "term": "Other abnormal test result NOS",
      "count": 82
    },
    {
      "term": "Lethargy (see also Central nervous system depression in Neurological)",
      "count": 80
    },
    {
      "term": "Anxiety",
      "count": 74
    },
    {
      "term": "Urinary tract infection",
      "count": 74
    },
    {
      "term": "Elevated creatinine",
      "count": 72
    },
    {
      "term": "Polyuria",
      "count": 69
    },
    {
      "term": "Shaking",
      "count": 65
    },
    {
      "term": "Bradycardia",
      "count": 62
    },
    {
      "term": "Vocalisation",
      "count": 61
    },
    {
      "term": "Drooling",
      "count": 60
    },
    {
      "term": "Not eating",
      "count": 59
    },
    {
      "term": "Weakness",
      "count": 59
    },
    {
      "term": "Tachycardia",
      "count": 53
    },
    {
      "term": "Anaemia NOS",
      "count": 51
    },
    {
      "term": "Hyperphosphataemia",
      "count": 46
    },
    {
      "term": "Dehydration",
      "count": 44
    },
    {
      "term": "Leucocytosis NOS",
      "count": 44
    },
    {
      "term": "Elevated liver enzymes",
      "count": 43
    },
    {
      "term": "Inappetence",
      "count": 43
    },
    {
      "term": "Hypersalivation",
      "count": 42
    },
    {
      "term": "Proteinuria",
      "count": 42
    },
    {
      "term": "Increased heart rate",
      "count": 41
    },
    {
      "term": "Hyperthermia",
      "count": 40
    },
    {
      "term": "Pacing",
      "count": 40
    },
    {
      "term": "Renal failure",
      "count": 40
    },
    {
      "term": "Tremor",
      "count": 40
    },
    {
      "term": "Loose stool",
      "count": 37
    },
    {
      "term": "Decreased urine concentration",
      "count": 36
    },
    {
      "term": "Fever",
      "count": 35
    },
    {
      "term": "Abnormal radiograph finding",
      "count": 34
    },
    {
      "term": "Abnormal ultrasound finding",
      "count": 34
    },
    {
      "term": "Haematuria",
      "count": 34
    },
    {
      "term": "Inappropriate urination",
      "count": 34
    },
    {
      "term": "Twitching",
      "count": 33
    },
    {
      "term": "Drug administration error",
      "count": 32
    },
    {
      "term": "INEFFECTIVE, LOSS OF EFFECT",
      "count": 31
    },
    {
      "term": "Limb weakness",
      "count": 31
    },
    {
      "term": "Disorientation",
      "count": 30
    },
    {
      "term": "Hyperglycaemia",
      "count": 30
    },
    {
      "term": "Pruritus",
      "count": 30
    },
    {
      "term": "Aggression",
      "count": 29
    },
    {
      "term": "Nausea",
      "count": 29
    },
    {
      "term": "Bloody diarrhoea",
      "count": 28
    },
    {
      "term": "Depression",
      "count": 27
    },
    {
      "term": "Pale mucous membrane",
      "count": 27
    },
    {
      "term": "Collapse NOS (see also 'Cardio-vascular' and 'Neurological disorders')",
      "count": 25
    },
    {
      "term": "Confusion",
      "count": 25
    },
    {
      "term": "Elevated renal parameters",
      "count": 25
    },
    {
      "term": "Reddening of the skin",
      "count": 25
    },
    {
      "term": "Unable to stand",
      "count": 25
    },
    {
      "term": "Cough",
      "count": 24
    },
    {
      "term": "Elevated symmetrical dimethylarginine (SDMA)",
      "count": 24
    },
    {
      "term": "Reluctant to move",
      "count": 24
    },
    {
      "term": "Dilated pupils",
      "count": 23
    },
    {
      "term": "Hyperactivity",
      "count": 23
    },
    {
      "term": "Arrhythmia",
      "count": 22
    },
    {
      "term": "Elevated gamma-glutamyl transferase (GGT)",
      "count": 22
    },
    {
      "term": "Frequent urination",
      "count": 22
    },
    {
      "term": "Lack of efficacy (endoparasite) - hookworm",
      "count": 22
    },
    {
      "term": "Malaise",
      "count": 22
    },
    {
      "term": "Neutrophilia",
      "count": 22
    },
    {
      "term": "Tachypnoea",
      "count": 22
    },
    {
      "term": "Urinary retention",
      "count": 22
    },
    {
      "term": "Walking difficulty",
      "count": 22
    },
    {
      "term": "Abnormal breathing",
      "count": 21
    },
    {
      "term": "Blindness",
      "count": 21
    },
    {
      "term": "Elevated total bilirubin",
      "count": 21
    },
    {
      "term": "Pain NOS",
      "count": 21
    },
    {
      "term": "Excessive thirst",
      "count": 20
    },
    {
      "term": "Hives (see also 'Skin')",
      "count": 20
    },
    {
      "term": "Hyperkalaemia",
      "count": 20
    }
  ]
}