{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-07-02"
  },
  "results": [
    {
      "term": "Lack of efficacy - NOS",
      "count": 3664
    },
    {
      "term": "Vomiting",
      "count": 3333
    },
    {
      "term": "INEFFECTIVE, ATOPY CONTROL",
      "count": 2679
    },
    {
      "term": "Diarrhoea",
      "count": 2263
    },
    {
      "term": "Lethargy (see also Central nervous system depression in 'Neurological')",
      "count": 2145
    },
    {
      "term": "INEFFECTIVE, LOSS OF EFFECT",
      "count": 1799
    },
    {
      "term": "Other abnormal test result NOS",
      "count": 1399
    },
    {
      "term": "Elevated alanine aminotransferase (ALT)",
      "count": 1133
    },
    {
      "term": "Seizure NOS",
      "count": 1121
    },
    {
      "term": "Elevated serum alkaline phosphatase (SAP)",
      "count": 1052
    },
    {
      "term": "Anorexia",
      "count": 952
    },
    {
      "term": "Leucopenia NOS",
      "count": 858
    },
    {
      "term": "Overdose",
      "count": 806
    },
    {
      "term": "Death by euthanasia",
      "count": 779
    },
    {
      "term": "Lethargy (see also Central nervous system depression in Neurological)",
      "count": 778
    },
    {
      "term": "Behavioural disorder NOS",
      "count": 775
    },
    {
      "term": "Polydipsia",
      "count": 735
    },
    {
      "term": "Decreased appetite",
      "count": 675
    },
    {
      "term": "Weight loss",
      "count": 667
    },
    {
      "term": "Polyuria",
      "count": 635
    },
    {
      "term": "Neutropenia",
      "count": 612
    },
    {
      "term": "Inappropriate schedule of drug administration",
      "count": 593
    },
    {
      "term": "Not eating",
      "count": 593
    },
    {
      "term": "Dermal mass",
      "count": 589
    },
    {
      "term": "Death",
      "count": 585
    },
    {
      "term": "Partial lack of efficacy",
      "count": 577
    },
    {
      "term": "Underdose",
      "count": 573
    },
    {
      "term": "Aggression",
      "count": 565
    },
    {
      "term": "Anaemia NOS",
      "count": 537
    },
    {
      "term": "Elevated liver enzymes",
      "count": 515
    },
    {
      "term": "Panting",
      "count": 502
    },
    {
      "term": "Pruritus",
      "count": 490
    },
    {
      "term": "Neoplasia NOS",
      "count": 480
    },
    {
      "term": "Fever",
      "count": 470
    },
    {
      "term": "Skin disorders NOS",
      "count": 467
    },
    {
      "term": "Elevated blood urea nitrogen (BUN)",
      "count": 436
    },
    {
      "term": "Abnormal radiograph finding",
      "count": 429
    },
    {
      "term": "Urinary tract infection",
      "count": 424
    },
    {
      "term": "Abnormal ultrasound finding",
      "count": 422
    },
    {
      "term": "Lymphopenia",
      "count": 422
    },
    {
      "term": "Skin lesion NOS",
      "count": 418
    },
    {
      "term": "Papilloma",
      "count": 417
    },
    {
      "term": "Hypoalbuminaemia",
      "count": 412
    },
    {
      "term": "Abnormal cytology",
      "count": 391
    },
    {
      "term": "Shaking",
      "count": 390
    },
    {
      "term": "Ataxia",
      "count": 370
    },
    {
      "term": "Proteinuria",
      "count": 368
    },
    {
      "term": "Elevated creatinine",
      "count": 361
    },
    {
      "term": "Leucocytosis NOS",
      "count": 357
    },
    {
      "term": "Thrombocytopenia",
      "count": 348
    },
    {
      "term": "Inappetence",
      "count": 340
    },
    {
      "term": "Anxiety",
      "count": 331
    },
    {
      "term": "Intentional misuse",
      "count": 330
    },
    {
      "term": "Skin lump",
      "count": 326
    },
    {
      "term": "Cough",
      "count": 323
    },
    {
      "term": "Emesis (multiple)",
      "count": 320
    },
    {
      "term": "Hives (see also 'Skin')",
      "count": 319
    },
    {
      "term": "Bloody diarrhoea",
      "count": 316
    },
    {
      "term": "Emesis",
      "count": 314
    },
    {
      "term": "Erythema (for urticaria see Immune SOC)",
      "count": 298
    },
    {
      "term": "Elevated serum alkaline phosphatase (ALP)",
      "count": 293
    },
    {
      "term": "Lymphoma",
      "count": 288
    },
    {
      "term": "Bacterial skin infection NOS",
      "count": 286
    },
    {
      "term": "Weight gain",
      "count": 284
    },
    {
      "term": "PR-SKIN, LESION(S)",
      "count": 281
    },
    {
      "term": "Inappropriate urination",
      "count": 280
    },
    {
      "term": "Urinary incontinence",
      "count": 279
    },
    {
      "term": "Loose stool",
      "count": 278
    },
    {
      "term": "Drug administration error",
      "count": 270
    },
    {
      "term": "Decreased urine concentration",
      "count": 251
    },
    {
      "term": "Itching",
      "count": 250
    },
    {
      "term": "Neutrophilia",
      "count": 250
    },
    {
      "term": "Medication error NOS",
      "count": 249
    },
    {
      "term": "Ear infection NOS",
      "count": 243
    },
    {
      "term": "Reddening of the skin",
      "count": 237
    },
    {
      "term": "Elevated total bilirubin",
      "count": 232
    },
    {
      "term": "Lack of efficacy (ectoparasite) - flea",
      "count": 231
    },
    {
      "term": "Dermatitis",
      "count": 226
    },
    {
      "term": "Urine abnormalities NOS",
      "count": 223
    },
    {
      "term": "Low platelet count",
      "count": 217
    },
    {
      "term": "Restlessness",
      "count": 217
    },
    {
      "term": "Weakness",
      "count": 216
    },
    {
      "term": "Pyoderma",
      "count": 215
    },
    {
      "term": "Vocalisation",
      "count": 215
    },
    {
      "term": "Skin and tissue infection NOS",
      "count": 212
    },
    {
      "term": "Haematuria",
      "count": 205
    },
    {
      "term": "Disorientation",
      "count": 203
    },
    {
      "term": "Histiocytoma",
      "count": 203
    },
    {
      "term": "Hypoproteinaemia",
      "count": 199
    },
    {
      "term": "Pain NOS",
      "count": 196
    },
    {
      "term": "Elevated cholesterol (total)",
      "count": 195
    },
    {
      "term": "Elevated gamma-glutamyl transferase (GGT)",
      "count": 192
    },
    {
      "term": "Mast cell tumour",
      "count": 191
    },
    {
      "term": "Accidental exposure",
      "count": 190
    },
    {
      "term": "Tremor",
      "count": 189
    },
    {
      "term": "Facial swelling (see also 'Skin')",
      "count": 187
    },
    {
      "term": "Hyperglycaemia",
      "count": 182
    },
    {
      "term": "Lameness",
      "count": 182
    },
    {
      "term": "Drug schedule prescribing error",
      "count": 181
    },
    {
      "term": "Crust",
      "count": 180
    }
  ]
}