{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-07-02"
  },
  "results": [
    {
      "term": "Vomiting",
      "count": 14339
    },
    {
      "term": "Lack of efficacy (endoparasite) - heartworm",
      "count": 10751
    },
    {
      "term": "Diarrhoea",
      "count": 5688
    },
    {
      "term": "Lack of efficacy (endoparasite) - hookworm",
      "count": 5573
    },
    {
      "term": "Lethargy (see also Central nervous system depression in 'Neurological')",
      "count": 5212
    },
    {
      "term": "Anaphylaxis",
      "count": 5034
    },
    {
      "term": "Facial swelling (see also 'Skin')",
      "count": 3718
    },
    {
      "term": "INEFFECTIVE, HEARTWORM LARVAE",
      "count": 3186
    },
    {
      "term": "Pruritus",
      "count": 3098
    },
    {
      "term": "Anorexia",
      "count": 2783
    },
    {
      "term": "Hives (see also 'Skin')",
      "count": 2704
    },
    {
      "term": "Lack of efficacy (endoparasite) - roundworm NOS",
      "count": 2629
    },
    {
      "term": "Depression",
      "count": 2344
    },
    {
      "term": "Seizure NOS",
      "count": 2185
    },
    {
      "term": "Pale mucous membrane",
      "count": 2006
    },
    {
      "term": "Lethargy (see also Central nervous system depression in Neurological)",
      "count": 1991
    },
    {
      "term": "Fever",
      "count": 1940
    },
    {
      "term": "Urticaria",
      "count": 1905
    },
    {
      "term": "Ataxia",
      "count": 1873
    },
    {
      "term": "Death",
      "count": 1837
    },
    {
      "term": "Lack of efficacy (ectoparasite) - flea",
      "count": 1819
    },
    {
      "term": "Behavioural disorder NOS",
      "count": 1810
    },
    {
      "term": "Lack of efficacy (endoparasite) - NOS",
      "count": 1797
    },
    {
      "term": "Other abnormal test result NOS",
      "count": 1615
    },
    {
      "term": "Facial oedema",
      "count": 1498
    },
    {
      "term": "Lack of efficacy (endoparasite) - tapeworm",
      "count": 1442
    },
    {
      "term": "Panting",
      "count": 1355
    },
    {
      "term": "Bloody diarrhoea",
      "count": 1321
    },
    {
      "term": "Emesis",
      "count": 1292
    },
    {
      "term": "Elevated alanine aminotransferase (ALT)",
      "count": 1282
    },
    {
      "term": "Death by euthanasia",
      "count": 1279
    },
    {
      "term": "Medication error NOS",
      "count": 1266
    },
    {
      "term": "Lack of efficacy (endoparasite) - whipworm",
      "count": 1237
    },
    {
      "term": "Lack of efficacy - NOS",
      "count": 1206
    },
    {
      "term": "Weight loss",
      "count": 1152
    },
    {
      "term": "Anaphylactoid reaction",
      "count": 1150
    },
    {
      "term": "Not eating",
      "count": 1050
    },
    {
      "term": "Shaking",
      "count": 1001
    },
    {
      "term": "Decreased appetite",
      "count": 930
    },
    {
      "term": "Erythema (for urticaria see Immune SOC)",
      "count": 930
    },
    {
      "term": "Emesis (multiple)",
      "count": 927
    },
    {
      "term": "Facial swelling (see also Skin)",
      "count": 906
    },
    {
      "term": "Weakness",
      "count": 902
    },
    {
      "term": "Leucocytosis NOS",
      "count": 896
    },
    {
      "term": "Convulsion",
      "count": 862
    },
    {
      "term": "Lack of efficacy (bacteria) - Borrelia",
      "count": 840
    },
    {
      "term": "Hypersalivation",
      "count": 820
    },
    {
      "term": "Elevated serum alkaline phosphatase (SAP)",
      "count": 774
    },
    {
      "term": "Anaemia NOS",
      "count": 771
    },
    {
      "term": "INEFFECTIVE, HOOKS",
      "count": 756
    },
    {
      "term": "Cough",
      "count": 720
    },
    {
      "term": "Tachycardia",
      "count": 717
    },
    {
      "term": "Trembling",
      "count": 710
    },
    {
      "term": "Hives (see also Skin)",
      "count": 709
    },
    {
      "term": "Intentional misuse",
      "count": 694
    },
    {
      "term": "Itching",
      "count": 689
    },
    {
      "term": "Dyspnoea",
      "count": 683
    },
    {
      "term": "Injection site swelling",
      "count": 673
    },
    {
      "term": "Vocalisation",
      "count": 642
    },
    {
      "term": "Drug dose administration interval too long",
      "count": 638
    },
    {
      "term": "Abnormal radiograph finding",
      "count": 637
    },
    {
      "term": "Overdose",
      "count": 627
    },
    {
      "term": "Collapse NOS (see also 'Cardio-vascular' and 'Neurological disorders')",
      "count": 626
    },
    {
      "term": "Loose stool",
      "count": 618
    },
    {
      "term": "Hyperactivity",
      "count": 616
    },
    {
      "term": "Allergic reaction",
      "count": 615
    },
    {
      "term": "Thrombocytopenia",
      "count": 614
    },
    {
      "term": "Inappetence",
      "count": 593
    },
    {
      "term": "Reddening of the skin",
      "count": 570
    },
    {
      "term": "Pain NOS",
      "count": 561
    },
    {
      "term": "Elevated blood urea nitrogen (BUN)",
      "count": 547
    },
    {
      "term": "Dehydration",
      "count": 533
    },
    {
      "term": "Neutrophilia",
      "count": 533
    },
    {
      "term": "Hypersensitivity reaction",
      "count": 507
    },
    {
      "term": "Restlessness",
      "count": 506
    },
    {
      "term": "Drug dose administration interval too short",
      "count": 500
    },
    {
      "term": "Accidental exposure",
      "count": 484
    },
    {
      "term": "Polydipsia",
      "count": 476
    },
    {
      "term": "Drooling",
      "count": 467
    },
    {
      "term": "Collapse (see also 'Cardio-vascular' and 'Systemic disorders')",
      "count": 466
    },
    {
      "term": "Elevated total bilirubin",
      "count": 460
    },
    {
      "term": "Agitation",
      "count": 446
    },
    {
      "term": "Lateral recumbency",
      "count": 422
    },
    {
      "term": "Tremor",
      "count": 403
    },
    {
      "term": "Recumbency",
      "count": 402
    },
    {
      "term": "Elevated liver enzymes",
      "count": 396
    },
    {
      "term": "Skin lesion NOS",
      "count": 385
    },
    {
      "term": "Immune mediated haemolytic anaemia",
      "count": 381
    },
    {
      "term": "Oedema NOS (see other SOCs for specific oedemas)",
      "count": 380
    },
    {
      "term": "Reluctant to move",
      "count": 377
    },
    {
      "term": "Tachypnoea",
      "count": 368
    },
    {
      "term": "Underdose",
      "count": 368
    },
    {
      "term": "Blood in vomit",
      "count": 364
    },
    {
      "term": "Hypotension",
      "count": 359
    },
    {
      "term": "Lack of efficacy (bacteria) - Anaplasma",
      "count": 359
    },
    {
      "term": "Elevated creatinine",
      "count": 355
    },
    {
      "term": "Twitching",
      "count": 348
    },
    {
      "term": "Shock",
      "count": 345
    },
    {
      "term": "Hypoalbuminaemia",
      "count": 339
    },
    {
      "term": "Anxiety",
      "count": 335
    }
  ]
}