{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-07-02"
  },
  "results": [
    {
      "term": "Lack of efficacy - NOS",
      "count": 178
    },
    {
      "term": "Vomiting",
      "count": 83
    },
    {
      "term": "Decreased haematocrit",
      "count": 71
    },
    {
      "term": "Weight loss",
      "count": 70
    },
    {
      "term": "Elevated creatinine",
      "count": 58
    },
    {
      "term": "Lethargy (see also Central nervous system depression in Neurological)",
      "count": 55
    },
    {
      "term": "Elevated blood urea nitrogen (BUN)",
      "count": 53
    },
    {
      "term": "Decreased appetite",
      "count": 49
    },
    {
      "term": "Not eating",
      "count": 47
    },
    {
      "term": "Death by euthanasia",
      "count": 44
    },
    {
      "term": "Pica NOS",
      "count": 42
    },
    {
      "term": "Behavioural disorder NOS",
      "count": 41
    },
    {
      "term": "Elevated symmetrical dimethylarginine (SDMA)",
      "count": 33
    },
    {
      "term": "Other abnormal test result NOS",
      "count": 33
    },
    {
      "term": "Death",
      "count": 26
    },
    {
      "term": "Decreased packed cell volume (PCV)",
      "count": 26
    },
    {
      "term": "Hyperphosphataemia",
      "count": 26
    },
    {
      "term": "Dehydration",
      "count": 23
    },
    {
      "term": "Decreased red blood cell count",
      "count": 20
    },
    {
      "term": "Diarrhoea",
      "count": 20
    },
    {
      "term": "Anaemia NOS",
      "count": 19
    },
    {
      "term": "Emesis (multiple)",
      "count": 19
    },
    {
      "term": "Weight gain",
      "count": 19
    },
    {
      "term": "Anorexia",
      "count": 16
    },
    {
      "term": "Neutrophilia",
      "count": 16
    },
    {
      "term": "Leucocytosis NOS",
      "count": 14
    },
    {
      "term": "Constipation",
      "count": 13
    },
    {
      "term": "Decreased haemoglobin",
      "count": 13
    },
    {
      "term": "Hiding",
      "count": 13
    },
    {
      "term": "High blood pressure",
      "count": 13
    },
    {
      "term": "Unwell",
      "count": 13
    },
    {
      "term": "Wobbliness",
      "count": 13
    },
    {
      "term": "Hypercalcaemia",
      "count": 12
    },
    {
      "term": "Hypertension",
      "count": 12
    },
    {
      "term": "Inappetence",
      "count": 12
    },
    {
      "term": "Elevated renal parameters",
      "count": 11
    },
    {
      "term": "Renal disorder NOS",
      "count": 11
    },
    {
      "term": "Seizure NOS",
      "count": 11
    },
    {
      "term": "UNPALATABLE",
      "count": 11
    },
    {
      "term": "Azotaemia",
      "count": 10
    },
    {
      "term": "Ataxia",
      "count": 9
    },
    {
      "term": "Elevated haematocrit",
      "count": 9
    },
    {
      "term": "Vocalisation",
      "count": 9
    },
    {
      "term": "Appetite loss",
      "count": 8
    },
    {
      "term": "Heart murmur",
      "count": 8
    },
    {
      "term": "Malaise",
      "count": 8
    },
    {
      "term": "Reluctant to move",
      "count": 8
    },
    {
      "term": "Sickness",
      "count": 8
    },
    {
      "term": "Sleepiness - systemic disorder",
      "count": 8
    },
    {
      "term": "Abnormal ultrasound finding",
      "count": 7
    },
    {
      "term": "Digestive tract disorder NOS",
      "count": 7
    },
    {
      "term": "Drooling",
      "count": 7
    },
    {
      "term": "Elevated alanine aminotransferase (ALT)",
      "count": 7
    },
    {
      "term": "Excessive chewing, licking and/or grooming",
      "count": 7
    },
    {
      "term": "Falling",
      "count": 7
    },
    {
      "term": "Hyperkalaemia",
      "count": 7
    },
    {
      "term": "Hypokalaemia",
      "count": 7
    },
    {
      "term": "Increased percentage reticulocytes",
      "count": 7
    },
    {
      "term": "Itching",
      "count": 7
    },
    {
      "term": "Lateral recumbency",
      "count": 7
    },
    {
      "term": "Lymphopenia",
      "count": 7
    },
    {
      "term": "Respiratory tract infection NOS",
      "count": 7
    },
    {
      "term": "Distress",
      "count": 6
    },
    {
      "term": "Hyperactivity",
      "count": 6
    },
    {
      "term": "Hyperproteinaemia",
      "count": 6
    },
    {
      "term": "Hypersalivation",
      "count": 6
    },
    {
      "term": "Limb weakness",
      "count": 6
    },
    {
      "term": "Product defect, product difficult to use/handle (see also 'Drug device difficult to use/handle')",
      "count": 6
    },
    {
      "term": "Scratching",
      "count": 6
    },
    {
      "term": "Unclassifiable adverse event",
      "count": 6
    },
    {
      "term": "Urinary tract infection",
      "count": 6
    },
    {
      "term": "Urine abnormalities NOS",
      "count": 6
    },
    {
      "term": "Weakness",
      "count": 6
    },
    {
      "term": "Abnormal breathing",
      "count": 5
    },
    {
      "term": "Abnormal radiograph finding",
      "count": 5
    },
    {
      "term": "Agitation",
      "count": 5
    },
    {
      "term": "Blindness",
      "count": 5
    },
    {
      "term": "Blood in urine",
      "count": 5
    },
    {
      "term": "Blood in vomit",
      "count": 5
    },
    {
      "term": "Fever",
      "count": 5
    },
    {
      "term": "Hair loss NOS",
      "count": 5
    },
    {
      "term": "Inappropriate urination",
      "count": 5
    },
    {
      "term": "Increased packed cell volume (PCV)",
      "count": 5
    },
    {
      "term": "Low platelet count",
      "count": 5
    },
    {
      "term": "Nasal bleeding",
      "count": 5
    },
    {
      "term": "Nausea",
      "count": 5
    },
    {
      "term": "Pruritus",
      "count": 5
    },
    {
      "term": "Thromboemboli",
      "count": 5
    },
    {
      "term": "Walking difficulty",
      "count": 5
    },
    {
      "term": "Cardiac disorder NOS",
      "count": 4
    },
    {
      "term": "Dilated pupils",
      "count": 4
    },
    {
      "term": "Discomfort NOS",
      "count": 4
    },
    {
      "term": "Elevated amylase",
      "count": 4
    },
    {
      "term": "Gagging",
      "count": 4
    },
    {
      "term": "Haematuria",
      "count": 4
    },
    {
      "term": "Hyperglycaemia",
      "count": 4
    },
    {
      "term": "Hypoalbuminaemia",
      "count": 4
    },
    {
      "term": "INEFFECTIVE, LOSS OF EFFECT",
      "count": 4
    },
    {
      "term": "Increased respiratory rate",
      "count": 4
    },
    {
      "term": "Itchy ears",
      "count": 4
    }
  ]
}