{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-07-02"
  },
  "results": [
    {
      "term": "Lack of efficacy - NOS",
      "count": 260
    },
    {
      "term": "Death by euthanasia",
      "count": 229
    },
    {
      "term": "Vomiting",
      "count": 215
    },
    {
      "term": "Weight loss",
      "count": 176
    },
    {
      "term": "Not eating",
      "count": 153
    },
    {
      "term": "Application site reddening",
      "count": 151
    },
    {
      "term": "Anorexia",
      "count": 150
    },
    {
      "term": "Death",
      "count": 133
    },
    {
      "term": "Lethargy (see also Central nervous system depression in 'Neurological')",
      "count": 132
    },
    {
      "term": "Lethargy (see also Central nervous system depression in Neurological)",
      "count": 132
    },
    {
      "term": "Behavioural disorder NOS",
      "count": 129
    },
    {
      "term": "Diarrhoea",
      "count": 118
    },
    {
      "term": "Vocalisation",
      "count": 116
    },
    {
      "term": "Decreased appetite",
      "count": 112
    },
    {
      "term": "Application site crust",
      "count": 107
    },
    {
      "term": "Ataxia",
      "count": 98
    },
    {
      "term": "Dehydration",
      "count": 97
    },
    {
      "term": "Application site irritation",
      "count": 83
    },
    {
      "term": "Elevated blood urea nitrogen (BUN)",
      "count": 82
    },
    {
      "term": "Hiding",
      "count": 78
    },
    {
      "term": "Other abnormal test result NOS",
      "count": 78
    },
    {
      "term": "Anaemia NOS",
      "count": 77
    },
    {
      "term": "Hyperglycaemia",
      "count": 75
    },
    {
      "term": "Application site erythema",
      "count": 67
    },
    {
      "term": "Elevated creatinine",
      "count": 67
    },
    {
      "term": "Application site skin scaling",
      "count": 63
    },
    {
      "term": "Inappetence",
      "count": 62
    },
    {
      "term": "Elevated alanine aminotransferase (ALT)",
      "count": 61
    },
    {
      "term": "Hypersalivation",
      "count": 60
    },
    {
      "term": "Drooling",
      "count": 57
    },
    {
      "term": "Fever",
      "count": 57
    },
    {
      "term": "Abnormal radiograph finding",
      "count": 56
    },
    {
      "term": "Seizure NOS",
      "count": 53
    },
    {
      "term": "Elevated total bilirubin",
      "count": 51
    },
    {
      "term": "Application site inflammation",
      "count": 49
    },
    {
      "term": "Dilated pupils",
      "count": 47
    },
    {
      "term": "Hyperactivity",
      "count": 47
    },
    {
      "term": "Application site scab",
      "count": 44
    },
    {
      "term": "Hypokalaemia",
      "count": 44
    },
    {
      "term": "Application site pain",
      "count": 43
    },
    {
      "term": "Application site residue",
      "count": 43
    },
    {
      "term": "Not drinking",
      "count": 43
    },
    {
      "term": "Decreased haematocrit",
      "count": 42
    },
    {
      "term": "Weakness",
      "count": 42
    },
    {
      "term": "Abnormal ultrasound finding",
      "count": 41
    },
    {
      "term": "Agitation",
      "count": 40
    },
    {
      "term": "Application site reaction NOS",
      "count": 40
    },
    {
      "term": "Pinnae disorder",
      "count": 40
    },
    {
      "term": "Elevated symmetrical dimethylarginine (SDMA)",
      "count": 39
    },
    {
      "term": "Leucocytosis NOS",
      "count": 39
    },
    {
      "term": "Neutrophilia",
      "count": 37
    },
    {
      "term": "Adipsia",
      "count": 34
    },
    {
      "term": "Hypothermia",
      "count": 32
    },
    {
      "term": "Application site warmth",
      "count": 30
    },
    {
      "term": "Intentional misuse",
      "count": 30
    },
    {
      "term": "Tachypnoea",
      "count": 30
    },
    {
      "term": "Falling",
      "count": 29
    },
    {
      "term": "Tachycardia",
      "count": 29
    },
    {
      "term": "Application site hair loss",
      "count": 28
    },
    {
      "term": "Constipation",
      "count": 28
    },
    {
      "term": "Walking difficulty",
      "count": 27
    },
    {
      "term": "Disorientation",
      "count": 26
    },
    {
      "term": "Hypoglycaemia",
      "count": 26
    },
    {
      "term": "Lateral recumbency",
      "count": 26
    },
    {
      "term": "Pale mucous membrane",
      "count": 26
    },
    {
      "term": "Decreased packed cell volume (PCV)",
      "count": 25
    },
    {
      "term": "Twitching",
      "count": 25
    },
    {
      "term": "Unwell",
      "count": 25
    },
    {
      "term": "Inappropriate urination",
      "count": 24
    },
    {
      "term": "Medication error",
      "count": 24
    },
    {
      "term": "Not himself/herself",
      "count": 24
    },
    {
      "term": "Proteinuria",
      "count": 24
    },
    {
      "term": "Emesis (multiple)",
      "count": 23
    },
    {
      "term": "Increased respiratory rate",
      "count": 23
    },
    {
      "term": "Ketosis",
      "count": 23
    },
    {
      "term": "Depression",
      "count": 22
    },
    {
      "term": "Lymphopenia",
      "count": 22
    },
    {
      "term": "Pacing",
      "count": 22
    },
    {
      "term": "Application site dry skin",
      "count": 21
    },
    {
      "term": "Elevated globulins",
      "count": 21
    },
    {
      "term": "Hypotension",
      "count": 21
    },
    {
      "term": "Nausea",
      "count": 21
    },
    {
      "term": "Pleural effusion",
      "count": 21
    },
    {
      "term": "Weight gain",
      "count": 21
    },
    {
      "term": "Heart murmur",
      "count": 20
    },
    {
      "term": "Hyperphosphataemia",
      "count": 20
    },
    {
      "term": "Hypoalbuminaemia",
      "count": 20
    },
    {
      "term": "Medication error NOS",
      "count": 20
    },
    {
      "term": "Monocytosis",
      "count": 20
    },
    {
      "term": "Ocular discharge",
      "count": 20
    },
    {
      "term": "Renal disorder NOS",
      "count": 20
    },
    {
      "term": "Restlessness",
      "count": 20
    },
    {
      "term": "Blindness",
      "count": 19
    },
    {
      "term": "Malaise",
      "count": 19
    },
    {
      "term": "Unresponsive to stimuli",
      "count": 19
    },
    {
      "term": "Aggression",
      "count": 18
    },
    {
      "term": "Application site itching",
      "count": 18
    },
    {
      "term": "Dyspnoea",
      "count": 18
    },
    {
      "term": "Hyponatremia",
      "count": 18
    },
    {
      "term": "Icterus",
      "count": 18
    }
  ]
}