{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-07-02"
  },
  "results": [
    {
      "term": "Emesis",
      "count": 42902
    },
    {
      "term": "Vomiting",
      "count": 38995
    },
    {
      "term": "Lethargy (see also Central nervous system depression in 'Neurological')",
      "count": 21869
    },
    {
      "term": "Lack of efficacy (endoparasite) - heartworm",
      "count": 14074
    },
    {
      "term": "Lack of efficacy - NOS",
      "count": 13033
    },
    {
      "term": "Diarrhoea",
      "count": 10790
    },
    {
      "term": "INEFFECTIVE, HEARTWORM LARVAE",
      "count": 9080
    },
    {
      "term": "Lack of efficacy (ectoparasite) - flea",
      "count": 7647
    },
    {
      "term": "Lack of efficacy (endoparasite) - hookworm",
      "count": 7561
    },
    {
      "term": "Seizure NOS",
      "count": 5760
    },
    {
      "term": "INEFFECTIVE, HOOKS",
      "count": 4843
    },
    {
      "term": "Behavioural disorder NOS",
      "count": 4818
    },
    {
      "term": "Other abnormal test result NOS",
      "count": 4658
    },
    {
      "term": "Not eating",
      "count": 3553
    },
    {
      "term": "Weight gain",
      "count": 3263
    },
    {
      "term": "Emesis (multiple)",
      "count": 3251
    },
    {
      "term": "Ataxia",
      "count": 3242
    },
    {
      "term": "Shaking",
      "count": 3212
    },
    {
      "term": "Anorexia",
      "count": 3187
    },
    {
      "term": "Decreased appetite",
      "count": 2801
    },
    {
      "term": "Overdose",
      "count": 2783
    },
    {
      "term": "INEFFECTIVE, ASCARIDS NOS",
      "count": 2780
    },
    {
      "term": "Weight loss",
      "count": 2748
    },
    {
      "term": "UNPALATABLE",
      "count": 2743
    },
    {
      "term": "Itching",
      "count": 2729
    },
    {
      "term": "Death",
      "count": 2685
    },
    {
      "term": "Pruritus",
      "count": 2227
    },
    {
      "term": "Lack of efficacy (endoparasite) - whipworm",
      "count": 2134
    },
    {
      "term": "Lack of efficacy (roundworm)",
      "count": 1854
    },
    {
      "term": "Death by euthanasia",
      "count": 1825
    },
    {
      "term": "Drug dose omission",
      "count": 1821
    },
    {
      "term": "Lack of efficacy (flea)",
      "count": 1807
    },
    {
      "term": "Trembling",
      "count": 1766
    },
    {
      "term": "Panting",
      "count": 1651
    },
    {
      "term": "Accidental exposure",
      "count": 1612
    },
    {
      "term": "Loose stool",
      "count": 1599
    },
    {
      "term": "Elevated alanine aminotransferase (ALT)",
      "count": 1570
    },
    {
      "term": "Lack of efficacy (endoparasite) - roundworm NOS",
      "count": 1520
    },
    {
      "term": "Tremor",
      "count": 1505
    },
    {
      "term": "Bloody diarrhoea",
      "count": 1451
    },
    {
      "term": "Underdose",
      "count": 1343
    },
    {
      "term": "Cough",
      "count": 1304
    },
    {
      "term": "Vocalisation",
      "count": 1296
    },
    {
      "term": "Drooling",
      "count": 1295
    },
    {
      "term": "Inappetence",
      "count": 1267
    },
    {
      "term": "Not drinking",
      "count": 1222
    },
    {
      "term": "Abnormal posture NOS",
      "count": 1211
    },
    {
      "term": "Disorientation",
      "count": 1150
    },
    {
      "term": "Malaise",
      "count": 1123
    },
    {
      "term": "Lack of efficacy (endoparasite) - tapeworm",
      "count": 1105
    },
    {
      "term": "Nausea",
      "count": 1072
    },
    {
      "term": "Scratching",
      "count": 1072
    },
    {
      "term": "Fever",
      "count": 970
    },
    {
      "term": "Anxiety",
      "count": 957
    },
    {
      "term": "Elevated serum alkaline phosphatase (SAP)",
      "count": 954
    },
    {
      "term": "Abnormal radiograph finding",
      "count": 947
    },
    {
      "term": "INEFFECTIVE, WHIPS",
      "count": 934
    },
    {
      "term": "Lethargy (see also Central nervous system depression in Neurological)",
      "count": 932
    },
    {
      "term": "Elevated liver enzymes",
      "count": 902
    },
    {
      "term": "Reddening of the skin",
      "count": 889
    },
    {
      "term": "Twitching",
      "count": 868
    },
    {
      "term": "Dehydration",
      "count": 854
    },
    {
      "term": "Hypersalivation",
      "count": 848
    },
    {
      "term": "Restlessness",
      "count": 848
    },
    {
      "term": "Weakness",
      "count": 787
    },
    {
      "term": "Hives (see also 'Skin')",
      "count": 769
    },
    {
      "term": "Pain NOS",
      "count": 769
    },
    {
      "term": "Walking difficulty",
      "count": 764
    },
    {
      "term": "Ear infection NOS",
      "count": 743
    },
    {
      "term": "Skin disorders NOS",
      "count": 739
    },
    {
      "term": "Lack of efficacy (heartworm)",
      "count": 733
    },
    {
      "term": "Inappropriate urination",
      "count": 695
    },
    {
      "term": "Digestive tract disorder NOS",
      "count": 693
    },
    {
      "term": "Allergy NOS",
      "count": 680
    },
    {
      "term": "Leucocytosis NOS",
      "count": 680
    },
    {
      "term": "Depression",
      "count": 665
    },
    {
      "term": "Eye disorder NOS (for photophobia see 'neurological')",
      "count": 655
    },
    {
      "term": "Appetite loss",
      "count": 645
    },
    {
      "term": "Neutrophilia",
      "count": 643
    },
    {
      "term": "Lack of efficacy (tapeworm)",
      "count": 636
    },
    {
      "term": "Anaemia NOS",
      "count": 602
    },
    {
      "term": "Pica NOS",
      "count": 602
    },
    {
      "term": "Lack of efficacy (protozoa) - Coccidia",
      "count": 583
    },
    {
      "term": "Pale mucous membrane",
      "count": 578
    },
    {
      "term": "Elevated blood urea nitrogen (BUN)",
      "count": 572
    },
    {
      "term": "Falling",
      "count": 563
    },
    {
      "term": "Star-gazing",
      "count": 558
    },
    {
      "term": "Facial swelling (see also 'Skin')",
      "count": 553
    },
    {
      "term": "Lack of efficacy (ectoparasite) - tick NOS",
      "count": 547
    },
    {
      "term": "Adipsia",
      "count": 545
    },
    {
      "term": "Abnormal breathing",
      "count": 538
    },
    {
      "term": "Elevated temperature",
      "count": 538
    },
    {
      "term": "Unable to stand",
      "count": 536
    },
    {
      "term": "Hair loss NOS",
      "count": 533
    },
    {
      "term": "Arthritis",
      "count": 525
    },
    {
      "term": "Polydipsia",
      "count": 522
    },
    {
      "term": "Drug dose administration interval too long",
      "count": 519
    },
    {
      "term": "Reluctant to move",
      "count": 512
    },
    {
      "term": "Urinary tract infection",
      "count": 507
    },
    {
      "term": "Musculoskeletal disorder NOS",
      "count": 488
    }
  ]
}