{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-07-02"
  },
  "results": [
    {
      "term": "INEFFECTIVE, HEARTWORM ADULTS",
      "count": 4219
    },
    {
      "term": "Lack of efficacy (endoparasite) - heartworm",
      "count": 2743
    },
    {
      "term": "Vomiting",
      "count": 2726
    },
    {
      "term": "Injection site swelling",
      "count": 2273
    },
    {
      "term": "Injection site pain",
      "count": 1458
    },
    {
      "term": "Pain NOS",
      "count": 1280
    },
    {
      "term": "Anorexia",
      "count": 1218
    },
    {
      "term": "Diarrhoea",
      "count": 1182
    },
    {
      "term": "Lethargy (see also Central nervous system depression in 'Neurological')",
      "count": 1126
    },
    {
      "term": "INEFFECTIVE, HEARTWORM LARVAE",
      "count": 1123
    },
    {
      "term": "Depression",
      "count": 1094
    },
    {
      "term": "Fever",
      "count": 993
    },
    {
      "term": "Death",
      "count": 951
    },
    {
      "term": "Elevated alanine aminotransferase (ALT)",
      "count": 937
    },
    {
      "term": "Cough",
      "count": 934
    },
    {
      "term": "Injection site lump",
      "count": 922
    },
    {
      "term": "Hypersalivation",
      "count": 891
    },
    {
      "term": "Panting",
      "count": 833
    },
    {
      "term": "Polypnoea",
      "count": 675
    },
    {
      "term": "Bloody diarrhoea",
      "count": 648
    },
    {
      "term": "Lack of efficacy - NOS",
      "count": 615
    },
    {
      "term": "Cardiac disorder NOS",
      "count": 588
    },
    {
      "term": "Ataxia",
      "count": 558
    },
    {
      "term": "Restlessness",
      "count": 530
    },
    {
      "term": "Elevated serum alkaline phosphatase (SAP)",
      "count": 518
    },
    {
      "term": "Weight loss",
      "count": 513
    },
    {
      "term": "Dyspnoea",
      "count": 509
    },
    {
      "term": "Anaphylaxis",
      "count": 494
    },
    {
      "term": "Vocalisation",
      "count": 462
    },
    {
      "term": "Leucocytosis NOS",
      "count": 457
    },
    {
      "term": "Pale mucous membrane",
      "count": 448
    },
    {
      "term": "Collapse (see also 'Cardio-vascular' and 'Systemic disorders')",
      "count": 410
    },
    {
      "term": "Other abnormal test result NOS",
      "count": 390
    },
    {
      "term": "Tachycardia",
      "count": 382
    },
    {
      "term": "Not eating",
      "count": 367
    },
    {
      "term": "Abnormal radiograph finding",
      "count": 340
    },
    {
      "term": "Injection site mass",
      "count": 338
    },
    {
      "term": "Anaemia NOS",
      "count": 326
    },
    {
      "term": "Weakness",
      "count": 315
    },
    {
      "term": "Facial oedema",
      "count": 312
    },
    {
      "term": "Death by euthanasia",
      "count": 299
    },
    {
      "term": "Elevated blood urea nitrogen (BUN)",
      "count": 290
    },
    {
      "term": "Facial swelling (see also 'Skin')",
      "count": 286
    },
    {
      "term": "Drooling",
      "count": 268
    },
    {
      "term": "Hind limb paresis",
      "count": 267
    },
    {
      "term": "Recumbency",
      "count": 261
    },
    {
      "term": "Tachypnoea",
      "count": 259
    },
    {
      "term": "Seizure NOS",
      "count": 248
    },
    {
      "term": "Injection site seroma",
      "count": 235
    },
    {
      "term": "Shaking",
      "count": 233
    },
    {
      "term": "Neutrophilia",
      "count": 231
    },
    {
      "term": "Thrombocytopenia",
      "count": 229
    },
    {
      "term": "Elevated total bilirubin",
      "count": 228
    },
    {
      "term": "Trembling",
      "count": 225
    },
    {
      "term": "Blood in vomit",
      "count": 222
    },
    {
      "term": "Underdose",
      "count": 218
    },
    {
      "term": "Lameness",
      "count": 211
    },
    {
      "term": "Injection site abscess",
      "count": 209
    },
    {
      "term": "Reluctant to move",
      "count": 209
    },
    {
      "term": "Elevated liver enzymes",
      "count": 202
    },
    {
      "term": "Elevated creatinine",
      "count": 201
    },
    {
      "term": "Injection site inflammation",
      "count": 197
    },
    {
      "term": "Urticaria",
      "count": 192
    },
    {
      "term": "Lethargy (see also Central nervous system depression in Neurological)",
      "count": 190
    },
    {
      "term": "Weight gain",
      "count": 189
    },
    {
      "term": "Cyanosis",
      "count": 188
    },
    {
      "term": "Haematuria",
      "count": 186
    },
    {
      "term": "Collapse NOS (see also 'Cardio-vascular' and 'Neurological disorders')",
      "count": 184
    },
    {
      "term": "Convulsion",
      "count": 184
    },
    {
      "term": "Decreased appetite",
      "count": 182
    },
    {
      "term": "Shock",
      "count": 182
    },
    {
      "term": "Behavioural disorder NOS",
      "count": 181
    },
    {
      "term": "Inappetence",
      "count": 177
    },
    {
      "term": "Dehydration",
      "count": 174
    },
    {
      "term": "Hives (see also 'Skin')",
      "count": 172
    },
    {
      "term": "Hypothermia",
      "count": 172
    },
    {
      "term": "Polydipsia",
      "count": 172
    },
    {
      "term": "Haemoptysis",
      "count": 158
    },
    {
      "term": "Lateral recumbency",
      "count": 155
    },
    {
      "term": "Hind limb paralysis",
      "count": 150
    },
    {
      "term": "Hyperglycaemia",
      "count": 148
    },
    {
      "term": "Respiratory distress",
      "count": 140
    },
    {
      "term": "Hyperphosphataemia",
      "count": 139
    },
    {
      "term": "Icterus",
      "count": 139
    },
    {
      "term": "Pacing",
      "count": 137
    },
    {
      "term": "Pruritus",
      "count": 137
    },
    {
      "term": "Digestive tract disorder NOS",
      "count": 135
    },
    {
      "term": "Anxiety",
      "count": 133
    },
    {
      "term": "Anaphylactic-type reaction",
      "count": 130
    },
    {
      "term": "Loose stool",
      "count": 126
    },
    {
      "term": "Musculoskeletal pain",
      "count": 126
    },
    {
      "term": "Erythema (for urticaria see Immune SOC)",
      "count": 125
    },
    {
      "term": "Abnormal cytology",
      "count": 122
    },
    {
      "term": "Proprioception abnormality",
      "count": 122
    },
    {
      "term": "Polyuria",
      "count": 119
    },
    {
      "term": "Urinary incontinence",
      "count": 119
    },
    {
      "term": "Elevated gamma-glutamyl transferase (GGT)",
      "count": 118
    },
    {
      "term": "Overdose",
      "count": 118
    },
    {
      "term": "Swelling NOS",
      "count": 118
    },
    {
      "term": "Elevated aspartate aminotransferase (AST)",
      "count": 116
    }
  ]
}