{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-07-02"
  },
  "results": [
    {
      "term": "INEFFECTIVE, SEDATION",
      "count": 637
    },
    {
      "term": "Death",
      "count": 373
    },
    {
      "term": "Lack of efficacy - NOS",
      "count": 298
    },
    {
      "term": "Sedation prolonged",
      "count": 211
    },
    {
      "term": "Vomiting",
      "count": 183
    },
    {
      "term": "Bradycardia",
      "count": 181
    },
    {
      "term": "Cardiac arrest",
      "count": 148
    },
    {
      "term": "Apnoea",
      "count": 123
    },
    {
      "term": "Convulsion",
      "count": 122
    },
    {
      "term": "Depression",
      "count": 110
    },
    {
      "term": "Diarrhoea",
      "count": 109
    },
    {
      "term": "Anorexia",
      "count": 97
    },
    {
      "term": "Labelled drug-drug interaction medication error",
      "count": 89
    },
    {
      "term": "Fever",
      "count": 76
    },
    {
      "term": "Tachycardia",
      "count": 73
    },
    {
      "term": "Elevated alanine aminotransferase (ALT)",
      "count": 71
    },
    {
      "term": "Elevated serum alkaline phosphatase (SAP)",
      "count": 65
    },
    {
      "term": "Lung oedema",
      "count": 63
    },
    {
      "term": "Cyanosis",
      "count": 62
    },
    {
      "term": "Death by euthanasia",
      "count": 60
    },
    {
      "term": "Vocalisation",
      "count": 57
    },
    {
      "term": "Hypersalivation",
      "count": 53
    },
    {
      "term": "Pale mucous membrane",
      "count": 53
    },
    {
      "term": "Aggression",
      "count": 50
    },
    {
      "term": "Recovery prolonged",
      "count": 50
    },
    {
      "term": "Ataxia",
      "count": 49
    },
    {
      "term": "Collapse (see also 'Cardio-vascular' and 'Systemic disorders')",
      "count": 48
    },
    {
      "term": "Dyspnoea",
      "count": 48
    },
    {
      "term": "Hyperactivity",
      "count": 48
    },
    {
      "term": "Elevated blood urea nitrogen (BUN)",
      "count": 37
    },
    {
      "term": "Trembling",
      "count": 35
    },
    {
      "term": "Arrhythmia",
      "count": 34
    },
    {
      "term": "Polypnoea",
      "count": 34
    },
    {
      "term": "Anaphylaxis",
      "count": 33
    },
    {
      "term": "Bloody diarrhoea",
      "count": 33
    },
    {
      "term": "Abnormal radiograph finding",
      "count": 32
    },
    {
      "term": "Elevated total bilirubin",
      "count": 32
    },
    {
      "term": "Haemoptysis",
      "count": 32
    },
    {
      "term": "Twitching",
      "count": 32
    },
    {
      "term": "Hypothermia",
      "count": 31
    },
    {
      "term": "Leucocytosis NOS",
      "count": 31
    },
    {
      "term": "Hypotension",
      "count": 29
    },
    {
      "term": "Anaemia NOS",
      "count": 28
    },
    {
      "term": "Weight loss",
      "count": 28
    },
    {
      "term": "INEFFECTIVE, ANESTHESIA",
      "count": 27
    },
    {
      "term": "No sign",
      "count": 27
    },
    {
      "term": "PR-LUNG(S), LESION(S)",
      "count": 26
    },
    {
      "term": "Tachypnoea",
      "count": 26
    },
    {
      "term": "Bradypnoea",
      "count": 25
    },
    {
      "term": "Elevated creatinine",
      "count": 25
    },
    {
      "term": "Partial lack of efficacy",
      "count": 24
    },
    {
      "term": "Confusion",
      "count": 23
    },
    {
      "term": "PR-LIVER, LESION(S)",
      "count": 23
    },
    {
      "term": "Cough",
      "count": 22
    },
    {
      "term": "Injection site swelling",
      "count": 22
    },
    {
      "term": "Lethargy (see also Central nervous system depression in Neurological)",
      "count": 22
    },
    {
      "term": "Elevated aspartate aminotransferase (AST)",
      "count": 21
    },
    {
      "term": "Icterus",
      "count": 21
    },
    {
      "term": "Thrombocytopenia",
      "count": 21
    },
    {
      "term": "Blood in vomit",
      "count": 20
    },
    {
      "term": "Facial oedema",
      "count": 19
    },
    {
      "term": "PR-KIDNEY(S), LESION(S)",
      "count": 19
    },
    {
      "term": "Recumbency",
      "count": 19
    },
    {
      "term": "Dehydration",
      "count": 18
    },
    {
      "term": "Hyperglycaemia",
      "count": 18
    },
    {
      "term": "Involuntary defecation",
      "count": 18
    },
    {
      "term": "PR-HEART, LESION(S)",
      "count": 18
    },
    {
      "term": "Deafness",
      "count": 17
    },
    {
      "term": "Nystagmus",
      "count": 17
    },
    {
      "term": "Restlessness",
      "count": 17
    },
    {
      "term": "Weakness",
      "count": 17
    },
    {
      "term": "Epistaxis",
      "count": 15
    },
    {
      "term": "Heart block NOS",
      "count": 15
    },
    {
      "term": "Hypoalbuminaemia",
      "count": 15
    },
    {
      "term": "Mydriasis",
      "count": 15
    },
    {
      "term": "Seizure NOS",
      "count": 15
    },
    {
      "term": "Urticaria",
      "count": 15
    },
    {
      "term": "Blindness",
      "count": 14
    },
    {
      "term": "Haematuria",
      "count": 14
    },
    {
      "term": "Hyperphosphataemia",
      "count": 14
    },
    {
      "term": "Immediate pain upon injection",
      "count": 14
    },
    {
      "term": "Loss of consciousness",
      "count": 14
    },
    {
      "term": "Oral bleeding",
      "count": 14
    },
    {
      "term": "Polydipsia",
      "count": 14
    },
    {
      "term": "Unrelated death",
      "count": 14
    },
    {
      "term": "Elevated liver enzymes",
      "count": 13
    },
    {
      "term": "Pain NOS",
      "count": 13
    },
    {
      "term": "Abdominal pain",
      "count": 12
    },
    {
      "term": "Lethargy (see also Central nervous system depression in 'Neurological')",
      "count": 12
    },
    {
      "term": "Loose stool",
      "count": 12
    },
    {
      "term": "Melaena",
      "count": 12
    },
    {
      "term": "Neutrophilia",
      "count": 12
    },
    {
      "term": "PR-LUNG(S), EDEMA",
      "count": 12
    },
    {
      "term": "Pulmonary congestion",
      "count": 12
    },
    {
      "term": "Shock",
      "count": 12
    },
    {
      "term": "Urinary incontinence",
      "count": 12
    },
    {
      "term": "Accidental exposure",
      "count": 11
    },
    {
      "term": "Behavioural disorder NOS",
      "count": 11
    },
    {
      "term": "Biting -aggression (see also 'Skin and appendages disorders')",
      "count": 11
    },
    {
      "term": "Coagulopathy",
      "count": 11
    }
  ]
}