{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-07-02"
  },
  "results": [
    {
      "term": "Vomiting",
      "count": 3201
    },
    {
      "term": "Diarrhoea",
      "count": 1543
    },
    {
      "term": "Other abnormal test result NOS",
      "count": 827
    },
    {
      "term": "Lack of efficacy (ectoparasite) - tick NOS",
      "count": 755
    },
    {
      "term": "Lack of efficacy (bacteria) - Borrelia",
      "count": 706
    },
    {
      "term": "Seizure NOS",
      "count": 695
    },
    {
      "term": "Lethargy (see also Central nervous system depression in 'Neurological')",
      "count": 625
    },
    {
      "term": "Lethargy (see also Central nervous system depression in Neurological)",
      "count": 596
    },
    {
      "term": "Lack of efficacy (endoparasite) - heartworm",
      "count": 538
    },
    {
      "term": "Behavioural disorder NOS",
      "count": 497
    },
    {
      "term": "Lack of efficacy (ectoparasite) - flea",
      "count": 494
    },
    {
      "term": "Not eating",
      "count": 439
    },
    {
      "term": "Lack of efficacy (endoparasite) - hookworm",
      "count": 332
    },
    {
      "term": "Ataxia",
      "count": 275
    },
    {
      "term": "Emesis (multiple)",
      "count": 268
    },
    {
      "term": "Itching",
      "count": 268
    },
    {
      "term": "Decreased appetite",
      "count": 260
    },
    {
      "term": "Shaking",
      "count": 238
    },
    {
      "term": "UNPALATABLE",
      "count": 197
    },
    {
      "term": "Lack of efficacy (endoparasite) - roundworm NOS",
      "count": 196
    },
    {
      "term": "Anorexia",
      "count": 193
    },
    {
      "term": "Loose stool",
      "count": 190
    },
    {
      "term": "Lack of efficacy (bacteria) - Anaplasma",
      "count": 187
    },
    {
      "term": "Bloody diarrhoea",
      "count": 183
    },
    {
      "term": "Death",
      "count": 178
    },
    {
      "term": "Lack of efficacy (endoparasite) - tapeworm",
      "count": 177
    },
    {
      "term": "Weight loss",
      "count": 177
    },
    {
      "term": "Lack of efficacy (flea)",
      "count": 174
    },
    {
      "term": "Lack of efficacy (bacteria) - NOS",
      "count": 162
    },
    {
      "term": "Panting",
      "count": 161
    },
    {
      "term": "Emesis",
      "count": 160
    },
    {
      "term": "Polyuria",
      "count": 157
    },
    {
      "term": "Tremor",
      "count": 152
    },
    {
      "term": "Scratching",
      "count": 151
    },
    {
      "term": "Lack of efficacy (bacteria) - Ehrlichia",
      "count": 144
    },
    {
      "term": "Not drinking",
      "count": 132
    },
    {
      "term": "Death by euthanasia",
      "count": 131
    },
    {
      "term": "Fever",
      "count": 130
    },
    {
      "term": "Lack of efficacy - NOS",
      "count": 130
    },
    {
      "term": "Pruritus",
      "count": 127
    },
    {
      "term": "Elevated alanine aminotransferase (ALT)",
      "count": 126
    },
    {
      "term": "Overdose",
      "count": 116
    },
    {
      "term": "Cough",
      "count": 115
    },
    {
      "term": "Inappropriate urination",
      "count": 108
    },
    {
      "term": "Not himself/herself",
      "count": 105
    },
    {
      "term": "Limping",
      "count": 101
    },
    {
      "term": "Malaise",
      "count": 101
    },
    {
      "term": "Falling",
      "count": 98
    },
    {
      "term": "Vocalisation",
      "count": 97
    },
    {
      "term": "Dehydration",
      "count": 95
    },
    {
      "term": "Twitching",
      "count": 93
    },
    {
      "term": "Polydipsia",
      "count": 92
    },
    {
      "term": "Trembling",
      "count": 88
    },
    {
      "term": "Pain NOS",
      "count": 87
    },
    {
      "term": "Anxiety",
      "count": 86
    },
    {
      "term": "Drooling",
      "count": 85
    },
    {
      "term": "Walking difficulty",
      "count": 82
    },
    {
      "term": "Inappetence",
      "count": 81
    },
    {
      "term": "Lack of efficacy (tick)",
      "count": 81
    },
    {
      "term": "Head tremor",
      "count": 80
    },
    {
      "term": "Urinary incontinence",
      "count": 80
    },
    {
      "term": "Anaemia NOS",
      "count": 78
    },
    {
      "term": "Neutrophilia",
      "count": 78
    },
    {
      "term": "Abnormal radiograph finding",
      "count": 77
    },
    {
      "term": "Elevated blood urea nitrogen (BUN)",
      "count": 77
    },
    {
      "term": "Leucocytosis NOS",
      "count": 76
    },
    {
      "term": "Hypersalivation",
      "count": 75
    },
    {
      "term": "Pale mucous membrane",
      "count": 74
    },
    {
      "term": "Weight gain",
      "count": 74
    },
    {
      "term": "Ear infection NOS",
      "count": 72
    },
    {
      "term": "Proteinuria",
      "count": 70
    },
    {
      "term": "Weakness",
      "count": 70
    },
    {
      "term": "Lameness",
      "count": 69
    },
    {
      "term": "Restlessness",
      "count": 69
    },
    {
      "term": "Disorientation",
      "count": 68
    },
    {
      "term": "Lack of efficacy (endoparasite) - whipworm",
      "count": 68
    },
    {
      "term": "Facial swelling (see also 'Skin')",
      "count": 66
    },
    {
      "term": "Accidental exposure",
      "count": 65
    },
    {
      "term": "Reddening of the skin",
      "count": 65
    },
    {
      "term": "Anaphylaxis",
      "count": 63
    },
    {
      "term": "Monocytosis",
      "count": 63
    },
    {
      "term": "Pica NOS",
      "count": 63
    },
    {
      "term": "Facial swelling (see also Skin)",
      "count": 61
    },
    {
      "term": "Hives (see also 'Skin')",
      "count": 61
    },
    {
      "term": "Low platelet count",
      "count": 61
    },
    {
      "term": "Frequent urination",
      "count": 60
    },
    {
      "term": "Licking",
      "count": 60
    },
    {
      "term": "Nausea",
      "count": 59
    },
    {
      "term": "Thrombocytopenia",
      "count": 59
    },
    {
      "term": "Hyperactivity",
      "count": 58
    },
    {
      "term": "Drinking a lot",
      "count": 57
    },
    {
      "term": "Hives (see also Skin)",
      "count": 57
    },
    {
      "term": "Elevated creatinine",
      "count": 56
    },
    {
      "term": "Hair loss NOS",
      "count": 56
    },
    {
      "term": "Allergy NOS",
      "count": 55
    },
    {
      "term": "Hyperphosphataemia",
      "count": 55
    },
    {
      "term": "Reluctant to move",
      "count": 55
    },
    {
      "term": "Elevated serum alkaline phosphatase (ALP)",
      "count": 54
    },
    {
      "term": "Lack of efficacy (virus) - parvovirus (including feline panleukopenia)",
      "count": 53
    },
    {
      "term": "Unable to stand",
      "count": 53
    }
  ]
}