{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-07-02"
  },
  "results": [
    {
      "term": "INEFFECTIVE, HEARTWORM LARVAE",
      "count": 37144
    },
    {
      "term": "Lack of efficacy (endoparasite) - hookworm",
      "count": 26103
    },
    {
      "term": "Lack of efficacy (endoparasite) - heartworm",
      "count": 24388
    },
    {
      "term": "Vomiting",
      "count": 22793
    },
    {
      "term": "Digestive tract disorder NOS",
      "count": 16656
    },
    {
      "term": "INEFFECTIVE, ASCARIDS NOS",
      "count": 11819
    },
    {
      "term": "Cardiac disorder NOS",
      "count": 10095
    },
    {
      "term": "Diarrhoea",
      "count": 9722
    },
    {
      "term": "Lack of efficacy - NOS",
      "count": 8746
    },
    {
      "term": "INEFFECTIVE, HOOKS",
      "count": 6958
    },
    {
      "term": "Lethargy (see also Central nervous system depression in 'Neurological')",
      "count": 6792
    },
    {
      "term": "Lack of efficacy (endoparasite) - roundworm NOS",
      "count": 5058
    },
    {
      "term": "Emesis",
      "count": 3220
    },
    {
      "term": "Seizure NOS",
      "count": 3075
    },
    {
      "term": "Anorexia",
      "count": 2884
    },
    {
      "term": "Ataxia",
      "count": 2776
    },
    {
      "term": "Depression",
      "count": 2690
    },
    {
      "term": "Lack of efficacy (protozoa) - Coccidia",
      "count": 2509
    },
    {
      "term": "Death",
      "count": 2351
    },
    {
      "term": "Underdose",
      "count": 1986
    },
    {
      "term": "Overdose",
      "count": 1966
    },
    {
      "term": "Other abnormal test result NOS",
      "count": 1873
    },
    {
      "term": "Behavioural disorder NOS",
      "count": 1789
    },
    {
      "term": "Lack of efficacy (endoparasite) - whipworm",
      "count": 1745
    },
    {
      "term": "Not eating",
      "count": 1565
    },
    {
      "term": "Loose stool",
      "count": 1544
    },
    {
      "term": "Death by euthanasia",
      "count": 1358
    },
    {
      "term": "Shaking",
      "count": 1285
    },
    {
      "term": "Trembling",
      "count": 1278
    },
    {
      "term": "Emesis (multiple)",
      "count": 1258
    },
    {
      "term": "Bloody diarrhoea",
      "count": 1254
    },
    {
      "term": "INEFFECTIVE, HEARTWORM ADULTS",
      "count": 1183
    },
    {
      "term": "Accidental exposure",
      "count": 1177
    },
    {
      "term": "Pruritus",
      "count": 1172
    },
    {
      "term": "Hypersalivation",
      "count": 1150
    },
    {
      "term": "Weight loss",
      "count": 1131
    },
    {
      "term": "Lack of efficacy (endoparasite) - tapeworm",
      "count": 1114
    },
    {
      "term": "Convulsion",
      "count": 1094
    },
    {
      "term": "Elevated alanine aminotransferase (ALT)",
      "count": 1069
    },
    {
      "term": "Panting",
      "count": 1053
    },
    {
      "term": "Drug dose administration interval too long",
      "count": 958
    },
    {
      "term": "Cough",
      "count": 910
    },
    {
      "term": "Lack of efficacy (ectoparasite) - flea",
      "count": 910
    },
    {
      "term": "Decreased appetite",
      "count": 901
    },
    {
      "term": "Mydriasis",
      "count": 899
    },
    {
      "term": "INEFFECTIVE, COCCIDIA",
      "count": 862
    },
    {
      "term": "Fever",
      "count": 827
    },
    {
      "term": "Itching",
      "count": 797
    },
    {
      "term": "INEFFECTIVE, WHIPS",
      "count": 781
    },
    {
      "term": "Inappetence",
      "count": 770
    },
    {
      "term": "Weight gain",
      "count": 745
    },
    {
      "term": "UNPALATABLE",
      "count": 743
    },
    {
      "term": "Vocalisation",
      "count": 731
    },
    {
      "term": "Elevated serum alkaline phosphatase (SAP)",
      "count": 715
    },
    {
      "term": "No sign",
      "count": 714
    },
    {
      "term": "Lethargy (see also Central nervous system depression in Neurological)",
      "count": 677
    },
    {
      "term": "Drooling",
      "count": 673
    },
    {
      "term": "Lack of efficacy (roundworm)",
      "count": 665
    },
    {
      "term": "Restlessness",
      "count": 663
    },
    {
      "term": "Abnormal radiograph finding",
      "count": 638
    },
    {
      "term": "Tremor",
      "count": 619
    },
    {
      "term": "Drug dose omission",
      "count": 603
    },
    {
      "term": "Blindness",
      "count": 588
    },
    {
      "term": "Twitching",
      "count": 567
    },
    {
      "term": "Leucocytosis NOS",
      "count": 553
    },
    {
      "term": "Weakness",
      "count": 540
    },
    {
      "term": "Hyperactivity",
      "count": 529
    },
    {
      "term": "Staggering",
      "count": 521
    },
    {
      "term": "Disorientation",
      "count": 495
    },
    {
      "term": "Anxiety",
      "count": 488
    },
    {
      "term": "Polydipsia",
      "count": 469
    },
    {
      "term": "Scratching",
      "count": 466
    },
    {
      "term": "Dehydration",
      "count": 462
    },
    {
      "term": "Elevated blood urea nitrogen (BUN)",
      "count": 444
    },
    {
      "term": "Elevated liver enzymes",
      "count": 434
    },
    {
      "term": "Pale mucous membrane",
      "count": 430
    },
    {
      "term": "Inappropriate urination",
      "count": 427
    },
    {
      "term": "Neutrophilia",
      "count": 421
    },
    {
      "term": "Anaemia NOS",
      "count": 407
    },
    {
      "term": "Pain NOS",
      "count": 404
    },
    {
      "term": "Falling",
      "count": 397
    },
    {
      "term": "Recumbency",
      "count": 385
    },
    {
      "term": "Blood in faeces",
      "count": 376
    },
    {
      "term": "Walking difficulty",
      "count": 374
    },
    {
      "term": "Not drinking",
      "count": 369
    },
    {
      "term": "Tachycardia",
      "count": 342
    },
    {
      "term": "Hives (see also 'Skin')",
      "count": 336
    },
    {
      "term": "Reluctant to move",
      "count": 336
    },
    {
      "term": "Confusion",
      "count": 329
    },
    {
      "term": "Hyperglycaemia",
      "count": 328
    },
    {
      "term": "Appetite loss",
      "count": 327
    },
    {
      "term": "Lack of efficacy (ectoparasite) - tick NOS",
      "count": 327
    },
    {
      "term": "Dyspnoea",
      "count": 316
    },
    {
      "term": "Pica NOS",
      "count": 315
    },
    {
      "term": "Collapse (see also 'Cardio-vascular' and 'Systemic disorders')",
      "count": 312
    },
    {
      "term": "Nausea",
      "count": 312
    },
    {
      "term": "Abdominal pain",
      "count": 303
    },
    {
      "term": "Mucous stool",
      "count": 300
    },
    {
      "term": "Aggression",
      "count": 298
    },
    {
      "term": "Elevated creatinine",
      "count": 292
    }
  ]
}