{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-07-02"
  },
  "results": [
    {
      "term": "Lack of efficacy - NOS",
      "count": 94
    },
    {
      "term": "Vomiting",
      "count": 83
    },
    {
      "term": "Lethargy (see also Central nervous system depression in 'Neurological')",
      "count": 59
    },
    {
      "term": "Not eating",
      "count": 58
    },
    {
      "term": "Elevated alanine aminotransferase (ALT)",
      "count": 56
    },
    {
      "term": "Weight loss",
      "count": 55
    },
    {
      "term": "Elevated total bilirubin",
      "count": 44
    },
    {
      "term": "Decreased appetite",
      "count": 43
    },
    {
      "term": "Elevated liver enzymes",
      "count": 40
    },
    {
      "term": "Diarrhoea",
      "count": 32
    },
    {
      "term": "Anorexia",
      "count": 31
    },
    {
      "term": "Lack of efficacy (fungi) - NOS",
      "count": 29
    },
    {
      "term": "Jaundice",
      "count": 28
    },
    {
      "term": "Elevated gamma-glutamyl transferase (GGT)",
      "count": 24
    },
    {
      "term": "Icterus",
      "count": 23
    },
    {
      "term": "Lethargy (see also Central nervous system depression in Neurological)",
      "count": 23
    },
    {
      "term": "Elevated serum alkaline phosphatase (SAP)",
      "count": 20
    },
    {
      "term": "Hyperglycaemia",
      "count": 18
    },
    {
      "term": "Death by euthanasia",
      "count": 17
    },
    {
      "term": "Other abnormal test result NOS",
      "count": 17
    },
    {
      "term": "Behavioural disorder NOS",
      "count": 16
    },
    {
      "term": "Dehydration",
      "count": 15
    },
    {
      "term": "Elevated serum alkaline phosphatase (ALP)",
      "count": 14
    },
    {
      "term": "Elevated aspartate aminotransferase (AST)",
      "count": 13
    },
    {
      "term": "Elevated cholesterol (total)",
      "count": 13
    },
    {
      "term": "Death",
      "count": 12
    },
    {
      "term": "Inappetence",
      "count": 12
    },
    {
      "term": "Neutrophilia",
      "count": 12
    },
    {
      "term": "Fever",
      "count": 9
    },
    {
      "term": "Hypersalivation",
      "count": 9
    },
    {
      "term": "Liver failure",
      "count": 9
    },
    {
      "term": "Abnormal ultrasound finding",
      "count": 8
    },
    {
      "term": "Cough",
      "count": 8
    },
    {
      "term": "Depression",
      "count": 8
    },
    {
      "term": "Elevated creatinine",
      "count": 8
    },
    {
      "term": "Elevated globulins",
      "count": 8
    },
    {
      "term": "Elevated amylase",
      "count": 7
    },
    {
      "term": "Monocytosis",
      "count": 7
    },
    {
      "term": "Abnormal cytology",
      "count": 6
    },
    {
      "term": "Anaemia NOS",
      "count": 6
    },
    {
      "term": "Appetite loss",
      "count": 6
    },
    {
      "term": "Breathing difficulty",
      "count": 6
    },
    {
      "term": "HYPERBILIRUBINEMIA",
      "count": 6
    },
    {
      "term": "Hiding",
      "count": 6
    },
    {
      "term": "Hyperproteinaemia",
      "count": 6
    },
    {
      "term": "Inappropriate urination",
      "count": 6
    },
    {
      "term": "Lymphopenia",
      "count": 6
    },
    {
      "term": "Nausea",
      "count": 6
    },
    {
      "term": "Pale mucous membrane",
      "count": 6
    },
    {
      "term": "Pruritus",
      "count": 6
    },
    {
      "term": "Pyrexia",
      "count": 6
    },
    {
      "term": "Sneezing",
      "count": 6
    },
    {
      "term": "Underdose",
      "count": 6
    },
    {
      "term": "Abnormal radiograph finding",
      "count": 5
    },
    {
      "term": "Aggression",
      "count": 5
    },
    {
      "term": "Constipation",
      "count": 5
    },
    {
      "term": "Crust",
      "count": 5
    },
    {
      "term": "Ear discharge",
      "count": 5
    },
    {
      "term": "Elevated ALT",
      "count": 5
    },
    {
      "term": "Hair loss NOS",
      "count": 5
    },
    {
      "term": "Leucocytosis NOS",
      "count": 5
    },
    {
      "term": "Loose stool",
      "count": 5
    },
    {
      "term": "Polydipsia",
      "count": 5
    },
    {
      "term": "Ataxia",
      "count": 4
    },
    {
      "term": "Decreased activity",
      "count": 4
    },
    {
      "term": "Decreased drinking",
      "count": 4
    },
    {
      "term": "Drooling",
      "count": 4
    },
    {
      "term": "Elevated SAP",
      "count": 4
    },
    {
      "term": "Elevated blood urea nitrogen (BUN)",
      "count": 4
    },
    {
      "term": "Elevated liver enzymes NOS",
      "count": 4
    },
    {
      "term": "Elevated symmetrical dimethylarginine (SDMA)",
      "count": 4
    },
    {
      "term": "Eosinophilia",
      "count": 4
    },
    {
      "term": "Foaming at the mouth",
      "count": 4
    },
    {
      "term": "Hyperalbuminaemia",
      "count": 4
    },
    {
      "term": "Hypercalcaemia",
      "count": 4
    },
    {
      "term": "Hypokalaemia",
      "count": 4
    },
    {
      "term": "Inappropriate schedule of drug administration",
      "count": 4
    },
    {
      "term": "Lack of efficacy",
      "count": 4
    },
    {
      "term": "Malaise",
      "count": 4
    },
    {
      "term": "Not urinating",
      "count": 4
    },
    {
      "term": "Polyuria",
      "count": 4
    },
    {
      "term": "Restlessness",
      "count": 4
    },
    {
      "term": "Tachycardia",
      "count": 4
    },
    {
      "term": "Thrombocytopenia",
      "count": 4
    },
    {
      "term": "Weakness",
      "count": 4
    },
    {
      "term": "Yellow mucous membranes",
      "count": 4
    },
    {
      "term": "Abdominal pain",
      "count": 3
    },
    {
      "term": "Accidental exposure",
      "count": 3
    },
    {
      "term": "Alopecia local",
      "count": 3
    },
    {
      "term": "Anisocoria",
      "count": 3
    },
    {
      "term": "Bilirubinuria",
      "count": 3
    },
    {
      "term": "Bloody diarrhoea",
      "count": 3
    },
    {
      "term": "Corneal ulcer",
      "count": 3
    },
    {
      "term": "Decreased bowel movements",
      "count": 3
    },
    {
      "term": "Diabetes",
      "count": 3
    },
    {
      "term": "Elevated AST",
      "count": 3
    },
    {
      "term": "Elevated pancreatic enzymes",
      "count": 3
    },
    {
      "term": "Elevated temperature",
      "count": 3
    },
    {
      "term": "Epiphora",
      "count": 3
    },
    {
      "term": "Erythema (for urticaria see Immune SOC)",
      "count": 3
    }
  ]
}