{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-07-02"
  },
  "results": [
    {
      "term": "Death",
      "count": 373
    },
    {
      "term": "Vomiting",
      "count": 345
    },
    {
      "term": "Bradycardia",
      "count": 311
    },
    {
      "term": "Cardiac arrest",
      "count": 229
    },
    {
      "term": "INEFFECTIVE, ANESTHESIA",
      "count": 220
    },
    {
      "term": "Anorexia",
      "count": 214
    },
    {
      "term": "Lethargy (see also Central nervous system depression in 'Neurological')",
      "count": 209
    },
    {
      "term": "Lack of efficacy - NOS",
      "count": 174
    },
    {
      "term": "Diarrhoea",
      "count": 169
    },
    {
      "term": "Other abnormal test result NOS",
      "count": 151
    },
    {
      "term": "Death by euthanasia",
      "count": 144
    },
    {
      "term": "Apnoea",
      "count": 139
    },
    {
      "term": "Not eating",
      "count": 138
    },
    {
      "term": "Lethargy (see also Central nervous system depression in Neurological)",
      "count": 135
    },
    {
      "term": "Tachycardia",
      "count": 133
    },
    {
      "term": "Seizure NOS",
      "count": 121
    },
    {
      "term": "Elevated alanine aminotransferase (ALT)",
      "count": 116
    },
    {
      "term": "Hypothermia",
      "count": 116
    },
    {
      "term": "Vocalisation",
      "count": 116
    },
    {
      "term": "Hypotension",
      "count": 103
    },
    {
      "term": "Elevated blood urea nitrogen (BUN)",
      "count": 100
    },
    {
      "term": "Abnormal radiograph finding",
      "count": 95
    },
    {
      "term": "Pale mucous membrane",
      "count": 95
    },
    {
      "term": "Decreased appetite",
      "count": 91
    },
    {
      "term": "Elevated total bilirubin",
      "count": 91
    },
    {
      "term": "Panting",
      "count": 90
    },
    {
      "term": "Bloody diarrhoea",
      "count": 89
    },
    {
      "term": "Elevated creatinine",
      "count": 88
    },
    {
      "term": "Leucocytosis NOS",
      "count": 88
    },
    {
      "term": "Elevated serum alkaline phosphatase (SAP)",
      "count": 84
    },
    {
      "term": "Weight loss",
      "count": 83
    },
    {
      "term": "Fever",
      "count": 82
    },
    {
      "term": "Recovery prolonged",
      "count": 82
    },
    {
      "term": "Ataxia",
      "count": 74
    },
    {
      "term": "Abnormal ultrasound finding",
      "count": 71
    },
    {
      "term": "Emesis",
      "count": 70
    },
    {
      "term": "Respiratory arrest",
      "count": 67
    },
    {
      "term": "Dehydration",
      "count": 63
    },
    {
      "term": "Hyperphosphataemia",
      "count": 63
    },
    {
      "term": "Injection site swelling",
      "count": 62
    },
    {
      "term": "Pain NOS",
      "count": 62
    },
    {
      "term": "Behavioural disorder NOS",
      "count": 61
    },
    {
      "term": "Inappetence",
      "count": 60
    },
    {
      "term": "Neutrophilia",
      "count": 60
    },
    {
      "term": "Elevated liver enzymes",
      "count": 59
    },
    {
      "term": "Hypoalbuminaemia",
      "count": 59
    },
    {
      "term": "Cyanosis",
      "count": 57
    },
    {
      "term": "Tachypnoea",
      "count": 57
    },
    {
      "term": "Anaemia NOS",
      "count": 56
    },
    {
      "term": "Dyspnoea",
      "count": 56
    },
    {
      "term": "Hypersalivation",
      "count": 56
    },
    {
      "term": "Facial swelling (see also 'Skin')",
      "count": 55
    },
    {
      "term": "Sedation",
      "count": 55
    },
    {
      "term": "Anaphylaxis",
      "count": 54
    },
    {
      "term": "Drooling",
      "count": 52
    },
    {
      "term": "Hypoglycaemia",
      "count": 50
    },
    {
      "term": "Anxiety",
      "count": 48
    },
    {
      "term": "Thrombocytopenia",
      "count": 48
    },
    {
      "term": "Peritonitis",
      "count": 47
    },
    {
      "term": "Decreased heart rate",
      "count": 45
    },
    {
      "term": "Underdose",
      "count": 45
    },
    {
      "term": "Abdominal pain",
      "count": 44
    },
    {
      "term": "Arrhythmia",
      "count": 43
    },
    {
      "term": "Bruising",
      "count": 42
    },
    {
      "term": "Hypoproteinaemia",
      "count": 42
    },
    {
      "term": "Regurgitation",
      "count": 42
    },
    {
      "term": "Depression",
      "count": 41
    },
    {
      "term": "Hyperthermia",
      "count": 41
    },
    {
      "term": "Weakness",
      "count": 41
    },
    {
      "term": "Elevated serum alkaline phosphatase (ALP)",
      "count": 40
    },
    {
      "term": "Hyperglycaemia",
      "count": 38
    },
    {
      "term": "Icterus",
      "count": 38
    },
    {
      "term": "Monocytosis",
      "count": 37
    },
    {
      "term": "Polydipsia",
      "count": 37
    },
    {
      "term": "Intestinal perforation",
      "count": 36
    },
    {
      "term": "Nystagmus",
      "count": 36
    },
    {
      "term": "Sedation prolonged",
      "count": 36
    },
    {
      "term": "Cough",
      "count": 35
    },
    {
      "term": "Nausea",
      "count": 35
    },
    {
      "term": "Partial lack of efficacy",
      "count": 35
    },
    {
      "term": "Polyuria",
      "count": 35
    },
    {
      "term": "Bradypnoea",
      "count": 34
    },
    {
      "term": "Lateral recumbency",
      "count": 34
    },
    {
      "term": "Shaking",
      "count": 34
    },
    {
      "term": "Fluid in abdomen NOS",
      "count": 33
    },
    {
      "term": "Not drinking",
      "count": 33
    },
    {
      "term": "Adipsia",
      "count": 32
    },
    {
      "term": "Elevated aspartate aminotransferase (AST)",
      "count": 32
    },
    {
      "term": "Azotaemia",
      "count": 31
    },
    {
      "term": "Disorientation",
      "count": 31
    },
    {
      "term": "Emesis (multiple)",
      "count": 31
    },
    {
      "term": "Injection site abscess",
      "count": 31
    },
    {
      "term": "Loose stool",
      "count": 31
    },
    {
      "term": "Decreased urine concentration",
      "count": 30
    },
    {
      "term": "Digestive tract disorder NOS",
      "count": 30
    },
    {
      "term": "Tremor",
      "count": 30
    },
    {
      "term": "Abnormal breathing",
      "count": 29
    },
    {
      "term": "Gastric perforation",
      "count": 29
    },
    {
      "term": "Haemorrhagic diarrhoea",
      "count": 29
    },
    {
      "term": "Heart block NOS",
      "count": 29
    }
  ]
}