{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-07-02"
  },
  "results": [
    {
      "term": "Vomiting",
      "count": 19858
    },
    {
      "term": "Lack of efficacy (ectoparasite) - flea",
      "count": 13545
    },
    {
      "term": "Emesis (multiple)",
      "count": 5521
    },
    {
      "term": "Lethargy (see also Central nervous system depression in 'Neurological')",
      "count": 4881
    },
    {
      "term": "Lack of efficacy (ectoparasite) - tick NOS",
      "count": 4826
    },
    {
      "term": "Diarrhoea",
      "count": 4374
    },
    {
      "term": "Seizure NOS",
      "count": 3102
    },
    {
      "term": "Lack of efficacy (tick)",
      "count": 1564
    },
    {
      "term": "Lack of efficacy (bacteria) - NOS",
      "count": 1493
    },
    {
      "term": "Drug administration error",
      "count": 1479
    },
    {
      "term": "Decreased appetite",
      "count": 1467
    },
    {
      "term": "Lack of efficacy (flea)",
      "count": 1462
    },
    {
      "term": "Not eating",
      "count": 1407
    },
    {
      "term": "Anorexia",
      "count": 1393
    },
    {
      "term": "Behavioural disorder NOS",
      "count": 1255
    },
    {
      "term": "Death by euthanasia",
      "count": 1115
    },
    {
      "term": "Lack of efficacy (ectoparasite) - NOS",
      "count": 1113
    },
    {
      "term": "Other abnormal test result NOS",
      "count": 1098
    },
    {
      "term": "Lack of efficacy (bacteria) - Borrelia",
      "count": 1067
    },
    {
      "term": "Lethargy (see also Central nervous system depression in Neurological)",
      "count": 998
    },
    {
      "term": "Shaking",
      "count": 997
    },
    {
      "term": "Ataxia",
      "count": 988
    },
    {
      "term": "Death",
      "count": 933
    },
    {
      "term": "Weight loss",
      "count": 860
    },
    {
      "term": "Overdose",
      "count": 850
    },
    {
      "term": "Elevated alanine aminotransferase (ALT)",
      "count": 847
    },
    {
      "term": "Bloody diarrhoea",
      "count": 787
    },
    {
      "term": "Panting",
      "count": 785
    },
    {
      "term": "Pruritus",
      "count": 754
    },
    {
      "term": "Lack of efficacy (bacteria) - Anaplasma",
      "count": 742
    },
    {
      "term": "Inappetence",
      "count": 673
    },
    {
      "term": "Elevated serum alkaline phosphatase (SAP)",
      "count": 653
    },
    {
      "term": "Tremor",
      "count": 639
    },
    {
      "term": "Scratching",
      "count": 635
    },
    {
      "term": "Itching",
      "count": 618
    },
    {
      "term": "Administration error NOS",
      "count": 615
    },
    {
      "term": "Loose stool",
      "count": 613
    },
    {
      "term": "Lack of efficacy (bacteria) - Ehrlichia",
      "count": 601
    },
    {
      "term": "Lack of efficacy (endoparasite) - heartworm",
      "count": 563
    },
    {
      "term": "Fever",
      "count": 551
    },
    {
      "term": "Falling",
      "count": 536
    },
    {
      "term": "Polydipsia",
      "count": 530
    },
    {
      "term": "Drooling",
      "count": 492
    },
    {
      "term": "Elevated blood urea nitrogen (BUN)",
      "count": 480
    },
    {
      "term": "Abnormal radiograph finding",
      "count": 479
    },
    {
      "term": "Leucocytosis NOS",
      "count": 479
    },
    {
      "term": "Not drinking",
      "count": 474
    },
    {
      "term": "Inappropriate urination",
      "count": 460
    },
    {
      "term": "Vocalisation",
      "count": 441
    },
    {
      "term": "Drug dose administration interval too long",
      "count": 428
    },
    {
      "term": "Underdose",
      "count": 426
    },
    {
      "term": "Neutrophilia",
      "count": 423
    },
    {
      "term": "Twitching",
      "count": 408
    },
    {
      "term": "UNPALATABLE",
      "count": 403
    },
    {
      "term": "Hives (see also 'Skin')",
      "count": 401
    },
    {
      "term": "Walking difficulty",
      "count": 390
    },
    {
      "term": "Anxiety",
      "count": 387
    },
    {
      "term": "Disorientation",
      "count": 377
    },
    {
      "term": "Dehydration",
      "count": 373
    },
    {
      "term": "Trembling",
      "count": 369
    },
    {
      "term": "Polyuria",
      "count": 367
    },
    {
      "term": "Weakness",
      "count": 358
    },
    {
      "term": "Elevated creatinine",
      "count": 351
    },
    {
      "term": "Cough",
      "count": 348
    },
    {
      "term": "Product Defect, General",
      "count": 347
    },
    {
      "term": "Drug dose administration interval too short",
      "count": 339
    },
    {
      "term": "Product problem",
      "count": 318
    },
    {
      "term": "Reluctant to move",
      "count": 311
    },
    {
      "term": "Drug dose omission",
      "count": 307
    },
    {
      "term": "Restlessness",
      "count": 303
    },
    {
      "term": "Unable to stand",
      "count": 302
    },
    {
      "term": "Hyperglycaemia",
      "count": 289
    },
    {
      "term": "Not himself/herself",
      "count": 289
    },
    {
      "term": "Limb weakness",
      "count": 284
    },
    {
      "term": "Abnormal ultrasound finding",
      "count": 277
    },
    {
      "term": "Lateral recumbency",
      "count": 269
    },
    {
      "term": "Urinary incontinence",
      "count": 268
    },
    {
      "term": "Elevated total bilirubin",
      "count": 267
    },
    {
      "term": "Reddening of the skin",
      "count": 266
    },
    {
      "term": "Hypersalivation",
      "count": 255
    },
    {
      "term": "INEFFECTIVE, LOSS OF EFFECT",
      "count": 249
    },
    {
      "term": "Anaemia NOS",
      "count": 248
    },
    {
      "term": "Thrombocytopenia",
      "count": 248
    },
    {
      "term": "Emesis",
      "count": 245
    },
    {
      "term": "Medication error",
      "count": 242
    },
    {
      "term": "Head tremor",
      "count": 240
    },
    {
      "term": "Lack of efficacy (endoparasite) - tapeworm",
      "count": 240
    },
    {
      "term": "Pale mucous membrane",
      "count": 238
    },
    {
      "term": "Monocytosis",
      "count": 237
    },
    {
      "term": "Hyperphosphataemia",
      "count": 233
    },
    {
      "term": "Decreased packed cell volume (PCV)",
      "count": 232
    },
    {
      "term": "Lack of efficacy - NOS",
      "count": 232
    },
    {
      "term": "Pain NOS",
      "count": 230
    },
    {
      "term": "Hypersensitivity reaction",
      "count": 227
    },
    {
      "term": "Aggression",
      "count": 225
    },
    {
      "term": "Pica NOS",
      "count": 225
    },
    {
      "term": "Pancreatitis",
      "count": 224
    },
    {
      "term": "Erythema (for urticaria see Immune SOC)",
      "count": 221
    },
    {
      "term": "Stiffness NOS",
      "count": 217
    },
    {
      "term": "Depression",
      "count": 216
    }
  ]
}