{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-07-02"
  },
  "results": [
    {
      "term": "Lack of efficacy (ectoparasite) - flea",
      "count": 3556
    },
    {
      "term": "Application site hair loss",
      "count": 2465
    },
    {
      "term": "Lethargy (see also Central nervous system depression in 'Neurological')",
      "count": 1233
    },
    {
      "term": "Drug administered at inappropriate site",
      "count": 1030
    },
    {
      "term": "Emesis (multiple)",
      "count": 819
    },
    {
      "term": "Foaming at the mouth",
      "count": 658
    },
    {
      "term": "Application site alopecia",
      "count": 583
    },
    {
      "term": "Behavioural disorder NOS",
      "count": 567
    },
    {
      "term": "Hypersalivation",
      "count": 497
    },
    {
      "term": "Vomiting",
      "count": 491
    },
    {
      "term": "Application site reddening",
      "count": 436
    },
    {
      "term": "Drooling",
      "count": 431
    },
    {
      "term": "Application site scab",
      "count": 419
    },
    {
      "term": "Lack of efficacy (ectoparasite) - tick NOS",
      "count": 417
    },
    {
      "term": "Not eating",
      "count": 415
    },
    {
      "term": "Hiding",
      "count": 405
    },
    {
      "term": "Decreased appetite",
      "count": 387
    },
    {
      "term": "Application site scratching",
      "count": 383
    },
    {
      "term": "Application site greasy fur",
      "count": 355
    },
    {
      "term": "Diarrhoea",
      "count": 354
    },
    {
      "term": "Ataxia",
      "count": 334
    },
    {
      "term": "Lethargy (see also Central nervous system depression in Neurological)",
      "count": 320
    },
    {
      "term": "Anorexia",
      "count": 277
    },
    {
      "term": "Weight loss",
      "count": 272
    },
    {
      "term": "Hyperactivity",
      "count": 260
    },
    {
      "term": "Death",
      "count": 259
    },
    {
      "term": "Application site irritation",
      "count": 244
    },
    {
      "term": "Licking at application site",
      "count": 244
    },
    {
      "term": "Seizure NOS",
      "count": 241
    },
    {
      "term": "Scratching",
      "count": 240
    },
    {
      "term": "Fever",
      "count": 232
    },
    {
      "term": "Vocalisation",
      "count": 230
    },
    {
      "term": "Death by euthanasia",
      "count": 220
    },
    {
      "term": "Application site itching",
      "count": 218
    },
    {
      "term": "Application site residue",
      "count": 204
    },
    {
      "term": "Panting",
      "count": 183
    },
    {
      "term": "Twitching",
      "count": 182
    },
    {
      "term": "Not drinking",
      "count": 181
    },
    {
      "term": "Accidental exposure",
      "count": 176
    },
    {
      "term": "Lack of efficacy (flea)",
      "count": 172
    },
    {
      "term": "Application site lesion",
      "count": 170
    },
    {
      "term": "Agitation",
      "count": 166
    },
    {
      "term": "Inappetence",
      "count": 164
    },
    {
      "term": "Application site hair change",
      "count": 162
    },
    {
      "term": "Itching",
      "count": 161
    },
    {
      "term": "Overdose",
      "count": 156
    },
    {
      "term": "Dehydration",
      "count": 152
    },
    {
      "term": "Localised hair loss",
      "count": 135
    },
    {
      "term": "Application site burn",
      "count": 133
    },
    {
      "term": "Pruritus",
      "count": 133
    },
    {
      "term": "Dilated pupils",
      "count": 128
    },
    {
      "term": "Application site erythema",
      "count": 127
    },
    {
      "term": "Tremor",
      "count": 126
    },
    {
      "term": "Not himself/herself",
      "count": 124
    },
    {
      "term": "Hair loss NOS",
      "count": 115
    },
    {
      "term": "Underdose",
      "count": 115
    },
    {
      "term": "Application site pruritus",
      "count": 112
    },
    {
      "term": "Falling",
      "count": 112
    },
    {
      "term": "Skin scab",
      "count": 112
    },
    {
      "term": "Other abnormal test result NOS",
      "count": 111
    },
    {
      "term": "General hair loss",
      "count": 107
    },
    {
      "term": "Hyperglycaemia",
      "count": 106
    },
    {
      "term": "Lack of efficacy (endoparasite) - tapeworm",
      "count": 105
    },
    {
      "term": "Licking",
      "count": 99
    },
    {
      "term": "INEFFECTIVE, LOSS OF EFFECT",
      "count": 98
    },
    {
      "term": "Elevated blood urea nitrogen (BUN)",
      "count": 97
    },
    {
      "term": "Application site sore",
      "count": 92
    },
    {
      "term": "Elevated alanine aminotransferase (ALT)",
      "count": 90
    },
    {
      "term": "Drug dose administration interval too short",
      "count": 89
    },
    {
      "term": "Excessive licking and/or grooming",
      "count": 87
    },
    {
      "term": "Shaking",
      "count": 87
    },
    {
      "term": "Walking difficulty",
      "count": 87
    },
    {
      "term": "Leucocytosis NOS",
      "count": 86
    },
    {
      "term": "Inappropriate urination",
      "count": 84
    },
    {
      "term": "Medication error",
      "count": 84
    },
    {
      "term": "Application site ulcer",
      "count": 80
    },
    {
      "term": "Elevated creatinine",
      "count": 75
    },
    {
      "term": "Lack of efficacy (protozoa) - NOS",
      "count": 75
    },
    {
      "term": "Aggression",
      "count": 73
    },
    {
      "term": "Lack of efficacy (tick)",
      "count": 73
    },
    {
      "term": "Head shake - behavioural disorder",
      "count": 72
    },
    {
      "term": "Application site self trauma",
      "count": 71
    },
    {
      "term": "Application site reaction NOS",
      "count": 70
    },
    {
      "term": "Open mouth breathing",
      "count": 69
    },
    {
      "term": "Disorientation",
      "count": 67
    },
    {
      "term": "Excessive chewing, licking and/or grooming",
      "count": 67
    },
    {
      "term": "Generalised itching",
      "count": 65
    },
    {
      "term": "Sleepiness - systemic disorder",
      "count": 65
    },
    {
      "term": "Sneezing",
      "count": 65
    },
    {
      "term": "Neutrophilia",
      "count": 63
    },
    {
      "term": "Weakness",
      "count": 63
    },
    {
      "term": "Application site inflammation",
      "count": 62
    },
    {
      "term": "Medication error NOS",
      "count": 61
    },
    {
      "term": "Wobbliness",
      "count": 61
    },
    {
      "term": "Application site stickiness",
      "count": 60
    },
    {
      "term": "Head tremor",
      "count": 60
    },
    {
      "term": "Stumbling gait",
      "count": 59
    },
    {
      "term": "Application site rash",
      "count": 58
    },
    {
      "term": "Drug administration error",
      "count": 58
    },
    {
      "term": "Reluctant to move",
      "count": 58
    }
  ]
}