{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-07-02"
  },
  "results": [
    {
      "term": "Lack of efficacy - NOS",
      "count": 347
    },
    {
      "term": "Vomiting",
      "count": 322
    },
    {
      "term": "Anorexia",
      "count": 309
    },
    {
      "term": "Depression",
      "count": 219
    },
    {
      "term": "Diarrhoea",
      "count": 170
    },
    {
      "term": "Seizure NOS",
      "count": 131
    },
    {
      "term": "Behavioural disorder NOS",
      "count": 125
    },
    {
      "term": "Accidental exposure",
      "count": 120
    },
    {
      "term": "Decreased appetite",
      "count": 119
    },
    {
      "term": "Lethargy (see also Central nervous system depression in Neurological)",
      "count": 112
    },
    {
      "term": "Lethargy (see also Central nervous system depression in 'Neurological')",
      "count": 105
    },
    {
      "term": "Aggression",
      "count": 102
    },
    {
      "term": "Shaking",
      "count": 102
    },
    {
      "term": "Weight loss",
      "count": 101
    },
    {
      "term": "Trembling",
      "count": 96
    },
    {
      "term": "Emesis",
      "count": 92
    },
    {
      "term": "Anxiety",
      "count": 89
    },
    {
      "term": "Panting",
      "count": 89
    },
    {
      "term": "Elevated alanine aminotransferase (ALT)",
      "count": 76
    },
    {
      "term": "Apprehension",
      "count": 73
    },
    {
      "term": "Vocalisation",
      "count": 71
    },
    {
      "term": "Ataxia",
      "count": 69
    },
    {
      "term": "INEFFECTIVE, LOSS OF EFFECT",
      "count": 69
    },
    {
      "term": "Not eating",
      "count": 64
    },
    {
      "term": "Death by euthanasia",
      "count": 63
    },
    {
      "term": "Convulsion",
      "count": 58
    },
    {
      "term": "Restlessness",
      "count": 56
    },
    {
      "term": "Other abnormal test result NOS",
      "count": 54
    },
    {
      "term": "Hyperactivity",
      "count": 46
    },
    {
      "term": "Polydipsia",
      "count": 46
    },
    {
      "term": "Underdose",
      "count": 43
    },
    {
      "term": "Death",
      "count": 42
    },
    {
      "term": "Overdose",
      "count": 41
    },
    {
      "term": "Polyuria",
      "count": 39
    },
    {
      "term": "Hypersalivation",
      "count": 35
    },
    {
      "term": "Elevated serum alkaline phosphatase (SAP)",
      "count": 34
    },
    {
      "term": "Lack of efficacy (endoparasite) - heartworm",
      "count": 33
    },
    {
      "term": "Mydriasis",
      "count": 32
    },
    {
      "term": "Inappetence",
      "count": 31
    },
    {
      "term": "Pruritus",
      "count": 31
    },
    {
      "term": "Emesis (multiple)",
      "count": 30
    },
    {
      "term": "Polypnoea",
      "count": 30
    },
    {
      "term": "Confusion",
      "count": 28
    },
    {
      "term": "Inappropriate urination",
      "count": 28
    },
    {
      "term": "Tachycardia",
      "count": 28
    },
    {
      "term": "Abnormal radiograph finding",
      "count": 27
    },
    {
      "term": "Disorientation",
      "count": 26
    },
    {
      "term": "Pacing",
      "count": 26
    },
    {
      "term": "Pain NOS",
      "count": 26
    },
    {
      "term": "Agitation",
      "count": 25
    },
    {
      "term": "Anaemia NOS",
      "count": 25
    },
    {
      "term": "Elevated serum alkaline phosphatase (ALP)",
      "count": 25
    },
    {
      "term": "Tremor",
      "count": 25
    },
    {
      "term": "Lack of efficacy (endoparasite) - hookworm",
      "count": 24
    },
    {
      "term": "Loose stool",
      "count": 24
    },
    {
      "term": "Medication error NOS",
      "count": 24
    },
    {
      "term": "Neutropenia",
      "count": 23
    },
    {
      "term": "Elevated blood urea nitrogen (BUN)",
      "count": 22
    },
    {
      "term": "Weight gain",
      "count": 22
    },
    {
      "term": "Leucopenia NOS",
      "count": 21
    },
    {
      "term": "Cough",
      "count": 20
    },
    {
      "term": "Falling",
      "count": 20
    },
    {
      "term": "Lymphopenia",
      "count": 20
    },
    {
      "term": "Urinary tract infection",
      "count": 20
    },
    {
      "term": "Partial lack of efficacy",
      "count": 19
    },
    {
      "term": "Proteinuria",
      "count": 19
    },
    {
      "term": "Decreased urine concentration",
      "count": 18
    },
    {
      "term": "Hiding",
      "count": 18
    },
    {
      "term": "Hyperkalaemia",
      "count": 18
    },
    {
      "term": "Hypoalbuminaemia",
      "count": 18
    },
    {
      "term": "Itching",
      "count": 18
    },
    {
      "term": "Thrombocytopenia",
      "count": 18
    },
    {
      "term": "Twitching",
      "count": 18
    },
    {
      "term": "Dehydration",
      "count": 17
    },
    {
      "term": "Elevated creatinine",
      "count": 17
    },
    {
      "term": "Fever",
      "count": 17
    },
    {
      "term": "Urinary incontinence",
      "count": 17
    },
    {
      "term": "Appetite loss",
      "count": 16
    },
    {
      "term": "Drooling",
      "count": 16
    },
    {
      "term": "Elevated aspartate aminotransferase (AST)",
      "count": 16
    },
    {
      "term": "Hyperglycaemia",
      "count": 16
    },
    {
      "term": "Sedation",
      "count": 16
    },
    {
      "term": "Decreased activity",
      "count": 15
    },
    {
      "term": "Digestive tract disorder NOS",
      "count": 15
    },
    {
      "term": "Elevated liver enzymes",
      "count": 15
    },
    {
      "term": "Elevated total bilirubin",
      "count": 15
    },
    {
      "term": "INEFFECTIVE, OTHER DRUG(S)",
      "count": 15
    },
    {
      "term": "Intentional misuse",
      "count": 15
    },
    {
      "term": "Nausea",
      "count": 15
    },
    {
      "term": "Abnormal ultrasound finding",
      "count": 14
    },
    {
      "term": "Not drinking",
      "count": 14
    },
    {
      "term": "Pale mucous membrane",
      "count": 14
    },
    {
      "term": "Walking difficulty",
      "count": 14
    },
    {
      "term": "Weakness",
      "count": 14
    },
    {
      "term": "Dilated pupils",
      "count": 13
    },
    {
      "term": "Head tremor",
      "count": 13
    },
    {
      "term": "Hind limb paresis",
      "count": 13
    },
    {
      "term": "Hypoproteinaemia",
      "count": 13
    },
    {
      "term": "Lameness",
      "count": 13
    },
    {
      "term": "Malaise",
      "count": 13
    }
  ]
}