{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-07-02"
  },
  "results": [
    {
      "term": "Lack of efficacy - NOS",
      "count": 1897
    },
    {
      "term": "Vomiting",
      "count": 546
    },
    {
      "term": "Ear discharge",
      "count": 451
    },
    {
      "term": "Ataxia",
      "count": 434
    },
    {
      "term": "Head tilt - ear disorder",
      "count": 432
    },
    {
      "term": "Head shake - ear disorder",
      "count": 379
    },
    {
      "term": "Corneal ulcer",
      "count": 352
    },
    {
      "term": "Deafness",
      "count": 343
    },
    {
      "term": "Lethargy (see also Central nervous system depression in 'Neurological')",
      "count": 328
    },
    {
      "term": "Nystagmus",
      "count": 312
    },
    {
      "term": "Behavioural disorder NOS",
      "count": 309
    },
    {
      "term": "Loss of hearing",
      "count": 263
    },
    {
      "term": "Ocular discharge",
      "count": 249
    },
    {
      "term": "Other abnormal test result NOS",
      "count": 238
    },
    {
      "term": "Vestibular disorder NOS",
      "count": 236
    },
    {
      "term": "Ear pain",
      "count": 222
    },
    {
      "term": "Not eating",
      "count": 221
    },
    {
      "term": "Diarrhoea",
      "count": 220
    },
    {
      "term": "Ear infection NOS",
      "count": 206
    },
    {
      "term": "Keratoconjunctivitis sicca",
      "count": 197
    },
    {
      "term": "Squinting",
      "count": 187
    },
    {
      "term": "Anorexia",
      "count": 186
    },
    {
      "term": "Lethargy (see also Central nervous system depression in Neurological)",
      "count": 185
    },
    {
      "term": "Schirmer tear test",
      "count": 180
    },
    {
      "term": "Decreased appetite",
      "count": 175
    },
    {
      "term": "Dry eye",
      "count": 171
    },
    {
      "term": "Other ear disorder NOS",
      "count": 149
    },
    {
      "term": "Otitis externa",
      "count": 147
    },
    {
      "term": "Ear canal erythema",
      "count": 145
    },
    {
      "term": "Facial paralysis",
      "count": 144
    },
    {
      "term": "Otorrhoea",
      "count": 144
    },
    {
      "term": "Neurogenic keratoconjunctivitis sicca (KCS)",
      "count": 140
    },
    {
      "term": "Nasal discharge",
      "count": 139
    },
    {
      "term": "Vocalisation",
      "count": 135
    },
    {
      "term": "Seizure NOS",
      "count": 129
    },
    {
      "term": "Corneal disorder NOS",
      "count": 124
    },
    {
      "term": "Death by euthanasia",
      "count": 124
    },
    {
      "term": "Hearing decreased",
      "count": 120
    },
    {
      "term": "Emesis (multiple)",
      "count": 118
    },
    {
      "term": "Abnormal cytology",
      "count": 113
    },
    {
      "term": "Lack of efficacy (fungi) - NOS",
      "count": 113
    },
    {
      "term": "Tympanic rupture",
      "count": 112
    },
    {
      "term": "Panting",
      "count": 111
    },
    {
      "term": "Ear canal inflammation",
      "count": 109
    },
    {
      "term": "Lack of efficacy (bacteria) - NOS",
      "count": 108
    },
    {
      "term": "CULTURE/TITER DATA ABNORMAL",
      "count": 105
    },
    {
      "term": "Blepharospasm",
      "count": 103
    },
    {
      "term": "Falling",
      "count": 103
    },
    {
      "term": "Ear pruritus",
      "count": 101
    },
    {
      "term": "Impaired hearing",
      "count": 101
    },
    {
      "term": "Pruritus",
      "count": 99
    },
    {
      "term": "Weight loss",
      "count": 99
    },
    {
      "term": "Eye disorder NOS (for photophobia see 'neurological')",
      "count": 96
    },
    {
      "term": "Dry nose",
      "count": 95
    },
    {
      "term": "Horizontal nystagmus",
      "count": 84
    },
    {
      "term": "Drooling",
      "count": 83
    },
    {
      "term": "Pain NOS",
      "count": 83
    },
    {
      "term": "Scratching",
      "count": 82
    },
    {
      "term": "Death",
      "count": 81
    },
    {
      "term": "Low tear flow",
      "count": 81
    },
    {
      "term": "Eye disorder NOS (for Photophobia see neurological)",
      "count": 80
    },
    {
      "term": "Pinnal erythema",
      "count": 80
    },
    {
      "term": "Crust",
      "count": 77
    },
    {
      "term": "Elevated alanine aminotransferase (ALT)",
      "count": 73
    },
    {
      "term": "Eye redness",
      "count": 73
    },
    {
      "term": "Conjunctivitis",
      "count": 70
    },
    {
      "term": "Shaking",
      "count": 70
    },
    {
      "term": "Walking difficulty",
      "count": 70
    },
    {
      "term": "Erythema (for urticaria see Immune SOC)",
      "count": 67
    },
    {
      "term": "Ear canal disorder",
      "count": 66
    },
    {
      "term": "Head shake - behavioural disorder",
      "count": 66
    },
    {
      "term": "Abnormal Schirmer tear test",
      "count": 65
    },
    {
      "term": "Anxiety",
      "count": 65
    },
    {
      "term": "Head tilt - neurological disorder (see also Head tilt - ear disorder)",
      "count": 65
    },
    {
      "term": "Disorientation",
      "count": 64
    },
    {
      "term": "Neutrophilia",
      "count": 64
    },
    {
      "term": "Dehydration",
      "count": 62
    },
    {
      "term": "External ear disorder NOS",
      "count": 62
    },
    {
      "term": "Hypersalivation",
      "count": 62
    },
    {
      "term": "Rubbing",
      "count": 62
    },
    {
      "term": "Malodour",
      "count": 61
    },
    {
      "term": "Polydipsia",
      "count": 61
    },
    {
      "term": "Application site erythema",
      "count": 60
    },
    {
      "term": "Restlessness",
      "count": 60
    },
    {
      "term": "Inappetence",
      "count": 59
    },
    {
      "term": "Leucocytosis NOS",
      "count": 59
    },
    {
      "term": "Sneezing",
      "count": 59
    },
    {
      "term": "Not drinking",
      "count": 57
    },
    {
      "term": "Abnormal menace reflex test",
      "count": 56
    },
    {
      "term": "Deafness NOS",
      "count": 56
    },
    {
      "term": "Elevated serum alkaline phosphatase (SAP)",
      "count": 56
    },
    {
      "term": "Eye pain",
      "count": 56
    },
    {
      "term": "Facial swelling (see also 'Skin')",
      "count": 56
    },
    {
      "term": "Fever",
      "count": 56
    },
    {
      "term": "Inappropriate urination",
      "count": 55
    },
    {
      "term": "Partial lack of efficacy",
      "count": 55
    },
    {
      "term": "Polyuria",
      "count": 55
    },
    {
      "term": "Otitis NOS",
      "count": 54
    },
    {
      "term": "Balance problem",
      "count": 53
    },
    {
      "term": "Swollen eye",
      "count": 53
    }
  ]
}