{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-07-02"
  },
  "results": [
    {
      "term": "Lack of efficacy - NOS",
      "count": 663
    },
    {
      "term": "Swollen vulva",
      "count": 341
    },
    {
      "term": "Death by euthanasia",
      "count": 116
    },
    {
      "term": "Vomiting",
      "count": 110
    },
    {
      "term": "Anorexia",
      "count": 96
    },
    {
      "term": "Vaginal swelling",
      "count": 90
    },
    {
      "term": "Urinary incontinence",
      "count": 89
    },
    {
      "term": "Lethargy (see also Central nervous system depression in 'Neurological')",
      "count": 82
    },
    {
      "term": "Decreased appetite",
      "count": 81
    },
    {
      "term": "Diarrhoea",
      "count": 80
    },
    {
      "term": "Vaginal discharge",
      "count": 79
    },
    {
      "term": "Weight loss",
      "count": 75
    },
    {
      "term": "Urinary tract infection",
      "count": 74
    },
    {
      "term": "Polydipsia",
      "count": 71
    },
    {
      "term": "Genital tract licking",
      "count": 68
    },
    {
      "term": "Vaginal haemorrhage",
      "count": 67
    },
    {
      "term": "Emesis (multiple)",
      "count": 64
    },
    {
      "term": "Thrombocytopenia",
      "count": 61
    },
    {
      "term": "Seizure NOS",
      "count": 58
    },
    {
      "term": "Elevated alanine aminotransferase (ALT)",
      "count": 54
    },
    {
      "term": "Other abnormal test result NOS",
      "count": 52
    },
    {
      "term": "Polyuria",
      "count": 51
    },
    {
      "term": "Not eating",
      "count": 49
    },
    {
      "term": "Lethargy (see also Central nervous system depression in Neurological)",
      "count": 48
    },
    {
      "term": "Elevated blood urea nitrogen (BUN)",
      "count": 45
    },
    {
      "term": "Elevated serum alkaline phosphatase (SAP)",
      "count": 43
    },
    {
      "term": "Aggression",
      "count": 41
    },
    {
      "term": "Anaemia NOS",
      "count": 41
    },
    {
      "term": "Behavioural disorder NOS",
      "count": 36
    },
    {
      "term": "Elevated creatinine",
      "count": 36
    },
    {
      "term": "Leucopenia NOS",
      "count": 34
    },
    {
      "term": "Proteinuria",
      "count": 33
    },
    {
      "term": "Attractiveness to males",
      "count": 30
    },
    {
      "term": "Haematuria",
      "count": 29
    },
    {
      "term": "Anxiety",
      "count": 28
    },
    {
      "term": "Faecal incontinence",
      "count": 28
    },
    {
      "term": "Ataxia",
      "count": 27
    },
    {
      "term": "Neutropenia",
      "count": 27
    },
    {
      "term": "Shaking",
      "count": 26
    },
    {
      "term": "Weakness",
      "count": 26
    },
    {
      "term": "Hyperpigmentation",
      "count": 25
    },
    {
      "term": "Abnormal ultrasound finding",
      "count": 24
    },
    {
      "term": "Death",
      "count": 24
    },
    {
      "term": "Panting",
      "count": 24
    },
    {
      "term": "Decreased urine concentration",
      "count": 22
    },
    {
      "term": "Depression",
      "count": 22
    },
    {
      "term": "Fever",
      "count": 22
    },
    {
      "term": "Inappetence",
      "count": 22
    },
    {
      "term": "Leucocytosis NOS",
      "count": 22
    },
    {
      "term": "Mammary hyperplasia",
      "count": 22
    },
    {
      "term": "Alopecia local",
      "count": 21
    },
    {
      "term": "Alopecia",
      "count": 20
    },
    {
      "term": "Elevated symmetrical dimethylarginine (SDMA)",
      "count": 20
    },
    {
      "term": "Vulvitis",
      "count": 20
    },
    {
      "term": "Blood in urine",
      "count": 19
    },
    {
      "term": "Elevated serum alkaline phosphatase (ALP)",
      "count": 19
    },
    {
      "term": "Increased sexual interest",
      "count": 19
    },
    {
      "term": "Decreased packed cell volume (PCV)",
      "count": 18
    },
    {
      "term": "Excessive licking and/or grooming",
      "count": 18
    },
    {
      "term": "INEFFECTIVE, OTHER DRUG(S)",
      "count": 18
    },
    {
      "term": "Pruritus",
      "count": 18
    },
    {
      "term": "Hyperphosphataemia",
      "count": 17
    },
    {
      "term": "Hypertension",
      "count": 17
    },
    {
      "term": "Licking",
      "count": 17
    },
    {
      "term": "Limb weakness",
      "count": 17
    },
    {
      "term": "Neutrophilia",
      "count": 17
    },
    {
      "term": "Abnormal cytology",
      "count": 16
    },
    {
      "term": "Abnormal radiograph finding",
      "count": 16
    },
    {
      "term": "Uterine disorder NOS",
      "count": 16
    },
    {
      "term": "Decreased haematocrit",
      "count": 15
    },
    {
      "term": "Decreased red blood cell count",
      "count": 15
    },
    {
      "term": "Frequent urination",
      "count": 15
    },
    {
      "term": "Lymphopenia",
      "count": 15
    },
    {
      "term": "Pacing",
      "count": 15
    },
    {
      "term": "Partial lack of efficacy",
      "count": 15
    },
    {
      "term": "Underdose",
      "count": 15
    },
    {
      "term": "Heart murmur",
      "count": 14
    },
    {
      "term": "Hyperkalaemia",
      "count": 14
    },
    {
      "term": "Inappropriate urination",
      "count": 14
    },
    {
      "term": "Restlessness",
      "count": 14
    },
    {
      "term": "Urine leakage",
      "count": 14
    },
    {
      "term": "Accidental exposure",
      "count": 13
    },
    {
      "term": "Decreased haemoglobin",
      "count": 13
    },
    {
      "term": "Emesis",
      "count": 13
    },
    {
      "term": "Hyperactivity",
      "count": 13
    },
    {
      "term": "Localised hair loss",
      "count": 13
    },
    {
      "term": "Loose stool",
      "count": 13
    },
    {
      "term": "Skin petechiae",
      "count": 13
    },
    {
      "term": "Cough",
      "count": 12
    },
    {
      "term": "General hair loss",
      "count": 12
    },
    {
      "term": "Hypoalbuminaemia",
      "count": 12
    },
    {
      "term": "INEFFECTIVE, LOSS OF EFFECT",
      "count": 12
    },
    {
      "term": "Overdose",
      "count": 12
    },
    {
      "term": "Pale mucous membrane",
      "count": 12
    },
    {
      "term": "Renal disorder NOS",
      "count": 12
    },
    {
      "term": "Dermatitis",
      "count": 11
    },
    {
      "term": "Elevated cholesterol (total)",
      "count": 11
    },
    {
      "term": "Erythema (for urticaria see Immune SOC)",
      "count": 11
    },
    {
      "term": "Falling",
      "count": 11
    },
    {
      "term": "Low platelet count",
      "count": 11
    }
  ]
}